Abstract:
:The coefficient of variation of estimates of three genetic distances (standard genetic distance of Nei, chord distance, FST) was examined with computer simulation to determine if large samples (per population) are necessary to precisely estimate genetic distances at loci with high levels of polymorphism. These simulations showed that loci with high mutation rates produce estimates of genetic distance with lower coefficients of variation than loci with lower mutation rates--without requiring larger sample sizes from each population. In addition, the rate at which increasing sample sizes decreases the coefficient of variation of estimates of genetic distances was shown to be approximately determined by the value of FST between the populations being sampled. When FST was greater than 0.05, sampling fewer than 20 individuals (per population) should be sufficient. When FST was less than 0.01, sampling 100 individuals (per population) or more will be useful.
journal_name
Heredity (Edinb)journal_title
Heredityauthors
Kalinowski STdoi
10.1038/sj.hdy.6800548keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
33-6issue
1eissn
0018-067Xissn
1365-2540pii
6800548journal_volume
94pub_type
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