Abstract:
:Prevention of malaria transmission throughout much of Africa is dependent on bednets that are impregnated with pyrethroid insecticides. Anopheles arabiensis is the major malaria vector in Chad and efforts to control this vector are threatened by the emergence of pyrethroid resistance. WHO bioassays revealed that An. arabiensis from Ndjamena is resistant to pyrethroids and dichlorodiphenyltrichloroethane (DDT) but fully susceptible to carbamates and organophosphates. No 1014F or 1014S kdr alleles were detected in this population. To determine the mechanisms that are responsible for resistance, genetic crosses were established between the Ndja strain and an insecticide susceptible population from Mozambique. Resistance was inherited as an autosomal trait and quantitative trait locus (QTL) mapping identified a single major locus on chromosome 2R, which explained 24.4% of the variance in resistance. This QTL is enriched in P450 genes including 25 cytochrome P450s in total. One of these, Cyp6p4 is 22-fold upregulated in the Ndja strain compared with the susceptible. Piperonyl butoxide (PBO) synergist and biochemical assays further support a role for P450s in conferring pyrethroid resistance in this population.
journal_name
Heredity (Edinb)journal_title
Heredityauthors
Witzig C,Parry M,Morgan JC,Irving H,Steven A,Cuamba N,Kerah-Hinzoumbé C,Ranson H,Wondji CSdoi
10.1038/hdy.2012.112subject
Has Abstractpub_date
2013-04-01 00:00:00pages
389-97issue
4eissn
0018-067Xissn
1365-2540pii
hdy2012112journal_volume
110pub_type
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