Physiology of biventricular pacing.

Abstract:

:Biventricular pacing (cardiac resynchronization therapy ) has been shown to be a very effective therapy for patients with heart failure and dyssynchrony, with improved survival now shown in a recent trial. Electrical dyssynchrony, usually quantified by the duration of the QRS complex, is distinct from mechanical dyssynchrony. Intraventricular mechanical dyssynchrony is most commonly manifest by decreased septal work with concomitant early lateral wall prestretch and subsequent inefficient late contraction. Intraventricular dyssynchrony appears to be more predictive of response to CRT than interventricular dyssynchrony. Mechanical left ventricular dyssynchrony also is associated with regional molecular derangements in connexin-43, stress response kinases, and tumor necrosis factor-alpha. These molecular derangements may lead to abnormalities in conduction velocity and action potential duration, which may predispose to ventricular arrhythmia. Biventricular pacing corrects abnormal regional wall stresses and results in electrical, mechanical, and molecular left ventricular remodeling.

journal_name

Curr Cardiol Rep

authors

Bilchick KC,Helm RH,Kass DA

doi

10.1007/BF02938362

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

358-65

issue

5

eissn

1523-3782

issn

1534-3170

journal_volume

9

pub_type

杂志文章,评审
  • Strain, strain rate, torsion, and twist: echocardiographic evaluation.

    abstract::Deformation imaging by tissue Doppler imaging (TDI) and speckle-tracking echocardiography (STE) are emerging clinical methods. TDI- and STE-derived parameters, such as myocardial strain and strain rate, as well as torsion and twist, provide detailed information about myocardial function and are associated with cardiov...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-015-0568-x

    authors: Opdahl A,Helle-Valle T,Skulstad H,Smiseth OA

    更新日期:2015-03-01 00:00:00

  • Hypertension in black patients: special issues and considerations.

    abstract::The excess risk of hypertension in black Americans continues to be a major health concern. Although there is considerable information regarding these disease trends, much of the major underpinnings of the etiology of hypertension remain unclear. The excess mortality in blacks due to heart disease, renal failure, and s...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-004-0048-1

    authors: Nesbitt SD

    更新日期:2004-11-01 00:00:00

  • Nontransplant surgical options for congestive heart failure.

    abstract::Although advanced heart failure has been considered the main indication for heart transplantation, the increasing number of candidates and shortage of organs for transplantation, with accumulating waiting lists, has originated another look into more conventional surgery, previously considered of prohibitive risk. In f...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-004-0028-5

    authors: Ferrão de Oliveira J,Antunes MJ

    更新日期:2004-05-01 00:00:00

  • Treatment of Bifurcation Lesions: Has DK Crush"ed" the Competition?

    abstract:PURPOSE:This paper reviews the double-kiss crush (DK crush) technique in coronary artery bifurcation lesions. The technical aspects of the procedure and the clinical data supporting its use are summarized. RECENT FINDINGS:Randomized studies support the adoption of DK technique in complex bifurcation lesions for both l...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-018-1024-5

    authors: Lynn BS,Hermiller JB

    更新日期:2018-09-01 00:00:00

  • Antegrade, retrograde, and combination strategies for chronic total occlusions.

    abstract::Chronic total occlusion (CTO) represents one of the most challenging lesion subsets faced by the interventional cardiologist. CTO is a common problem, being present in more than 30% of patients undergoing coronary angiography. Over the past 10 years, the success rate of recanalization has increased from approximately ...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-010-0131-8

    authors: Genereux P,Dangas G

    更新日期:2010-09-01 00:00:00

  • Utilizing risk scores in determining the optimal revascularization strategy for complex coronary artery disease.

    abstract::Percutaneous coronary intervention (PCI) of multivessel and/or left main stem disease have been shown to be potentially legitimate revascularization alternatives in appropriately selected patients. Risk stratification is an important component in guiding patients to identify the most appropriate revascularization moda...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-011-0202-5

    authors: Farooq V,Brugaletta S,Serruys PW

    更新日期:2011-10-01 00:00:00

  • Prognostic and Therapeutic Implications of Frailty in Older Adults with Heart Failure.

    abstract::Frailty is increasingly recognized in older adults with cardiovascular disease, particularly in those with heart failure (HF). A growing body of evidence has shown that frailty has a negative effect on survival, hospitalizations, disability, and quality of life. Beyond frailty, additional domains captured by a compreh...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-015-0651-3

    authors: Goldfarb M,Sheppard R,Afilalo J

    更新日期:2015-11-01 00:00:00

  • Advances in PET-Based Cardiac Amyloid Radiotracers.

    abstract::The gold standard for diagnosis of cardiac amyloidosis (CA) is endomyocardial biopsy showing Congo red staining followed by mass spectroscopy, but the diagnosis can also be made with high certainty by demonstration of typical cardiac imaging features along with amyloid on biopsy of another involved organ. The use of c...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-020-01284-3

    authors: Gallegos C,Miller EJ

    更新日期:2020-05-19 00:00:00

  • Prevention, Diagnosis, and Treatment of Cardiac Implantable Electronic Device Infections.

    abstract::Cardiac implantable electronic device (CIED) infections are complex medical problems that are increasingly encountered. They are associated with significant morbidity and mortality with tremendous economic cost. The current review will emphasize the prevention, diagnosis, and treatment of this clinical entity using th...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-016-0733-x

    authors: Leung S,Danik S

    更新日期:2016-06-01 00:00:00

  • Cardiac Computed Tomography (CT) Evaluation of Valvular Heart Disease in Transcatheter Interventions.

    abstract:PURPOSE OF REVIEW:To establish the actual role of CT in the growing field of transcatheter valve interventions (THV). RECENT FINDINGS:The development of empirical CT measurements, which are linked with outcomes. CT is a reliable technique for assessing risk and planning transcatheter valve interventions for mitral and...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-019-1241-6

    authors: Godoy M,Mugharbil A,Anastasius M,Leipsic J

    更新日期:2019-11-25 00:00:00

  • Selective or nonselective beta-adrenergic blockade in patients with congestive heart failure.

    abstract::Controlled clinical trials, performed in more than 13,000 patients, have consistently shown the beneficial effects of long-term beta-blocker therapy in patients with chronic heart failure. However, it is not clear whether this is a class effect or if it is specific only for some agents. Beneficial effects on the progn...

    journal_title:Current cardiology reports

    pub_type: 杂志文章

    doi:10.1007/s11886-000-0076-4

    authors: Metra M,Nodari S,Boldi E,Dei Cas L

    更新日期:2000-05-01 00:00:00

  • Aortic valve disease: current recommendations.

    abstract::Aortic stenosis is a common valvular abnormality. Surgical valve replacement is the standard of care for symptomatic patients with severe aortic stenosis and is appropriate for certain asymptomatic patients. Statin therapy may slow progression of the disease. Contrary to conventional wisdom, vasodilator therapy may in...

    journal_title:Current cardiology reports

    pub_type: 杂志文章

    doi:10.1007/s11886-004-0004-0

    authors: Botkin NF,Aurigemma GP

    更新日期:2004-03-01 00:00:00

  • Correction to: Cardiac Contractility Modulation: an Important Therapy in the Treatment of Advanced Heart Failure.

    abstract::The article title in the original publication contains a mistake. ...

    journal_title:Current cardiology reports

    pub_type: 已发布勘误

    doi:10.1007/s11886-020-01403-0

    authors: Edelson JB,Genuardi MV,Santangeli P,Birati EY

    更新日期:2020-09-08 00:00:00

  • Treatment of Functional Mitral Regurgitation in Heart Failure.

    abstract:PURPOSE OF REVIEW:To analyze the current state of the art of functional mitral regurgitation (FMR) treatment. RECENT FINDINGS:The first-line treatment of severe FMR consists of guideline medical therapy (GMT) and resynchronization therapy when indicated; the impact of new medical therapies like sacubitril/valsartan ne...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-019-1221-x

    authors: Fabris E,De Luca A,Vitrella G,Stolfo D,Masè M,Korcova R,Merlo M,Rakar S,Van't Hof AWJ,Kedhi E,Perkan A,Sinagra G

    更新日期:2019-11-16 00:00:00

  • Exome sequencing: new insights into lipoprotein disorders.

    abstract::Several next generation sequencing platforms allow for a DNA-to-diagnosis protocol to identify the molecular basis of monogenic dyslipidemias. However, recent reports of the application of whole genome or whole exome sequencing in families with severe dyslipidemias have largely identified genetic variants in known lip...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-014-0507-2

    authors: Farhan SM,Hegele RA

    更新日期:2014-07-01 00:00:00

  • 25 by 25: Achieving Global Reduction in Cardiovascular Mortality.

    abstract::Four non-communicable diseases-cardiovascular disease, chronic respiratory disease, diabetes mellitus, and cancer-account for over 60 % of all deaths globally. In recognition of this significant epidemic, the United Nations set forth a target of reducing the four major NCDs by 25 % by 2025. Cardiovascular disease alon...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-015-0679-4

    authors: Dugani S,Gaziano TA

    更新日期:2016-01-01 00:00:00

  • Weighing the evidence for infection as a risk factor for coronary heart disease.

    abstract::There has been considerable attention in recent years to the intriguing hypothesis that coronary heart disease and other atherosclerotic diseases may be caused by infection with pathogens such as Chlamydia pneumoniae, Helicobacter pylori, and cytomegalovirus. Supporting this hypothesis are studies that localize bacter...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-000-0082-6

    authors: O'Donnell CJ,Levy D

    更新日期:2000-07-01 00:00:00

  • Rheumatic Mitral Valve Stenosis: Diagnosis and Treatment Options.

    abstract:PURPOSE OF REVIEW:This review provides an update on rheumatic mitral stenosis. Acute rheumatic fever (RF), the sequela of group A β-hemolytic streptococcal infection, is the major etiology for mitral stenosis (MS). RECENT FINDINGS:While the incidence of acute RF in the Western world had substantially declined over the...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-019-1099-7

    authors: Wunderlich NC,Dalvi B,Ho SY,Küx H,Siegel RJ

    更新日期:2019-02-28 00:00:00

  • Percutaneous Endovascular Aortic Aneurysm Repair for Abdominal Aortic Aneurysm.

    abstract:PURPOSE OF REVIEW:This review discusses the benefits of a completely percutaneous approach to endovascular aortic aneurysm repair (EVAR), and provides an outline as to how this is performed by a multidisciplinary team of cardiologists and cardiovascular surgeons at a quaternary care community hospital. RECENT FINDINGS...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-018-1023-6

    authors: Huff CM,Silver MJ,Ansel GM

    更新日期:2018-07-26 00:00:00

  • Left ventricular assist devices and other devices for end-stage heart failure: utility of echocardiography.

    abstract::The burgeoning ranks of patients with heart failure, the limited number of organs available for heart transplant, and technological improvements have made ventricular assist devices (VADs) important therapeutic options for patients with acute and chronic cardiac decompensation. The increased use of VADs is paralleled ...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-010-0102-0

    authors: Kirkpatrick JN,Wiegers SE,Lang RM

    更新日期:2010-05-01 00:00:00

  • Recurrent Pericarditis: Modern Approach in 2016.

    abstract::Recurrent pericarditis is one of the most troublesome complications of pericarditis occurring in about one third of patients with a previous attack of pericarditis. The pathogenesis is presumed to be autoimmune and/or autoinflammatory in most cases. The mainstay of therapy for recurrences is physical restriction and a...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-016-0727-8

    authors: Imazio M,Adler Y,Charron P

    更新日期:2016-06-01 00:00:00

  • White Coat Hypertension and Cardiovascular Diseases: Innocent or Guilty.

    abstract:PURPOSE OF REVIEW:This review aims to clarify the cardiovascular risk of white coat hypertension (WCH). RECENT FINDINGS:Cardiovascular risk of WCH has been evaluated in multiple meta-analyses and population-based studies. International Database on Ambulatory Blood Pressure Monitoring in Relation to Cardiovascular Outc...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-018-0964-0

    authors: Abolbashari M

    更新日期:2018-03-08 00:00:00

  • Endovascular Management of Massive and Submassive Acute Pulmonary Embolism: Current Trends in Risk Stratification and Catheter-Directed Therapies.

    abstract:PURPOSE OF REVIEW:Acute pulmonary embolism (PE) is a common condition associated with high morbidity and mortality. Prior studies have evaluated the role of systemic fibrinolysis and catheter-directed therapy (CDT) in the management of PE. In this review, we examine current data on risk stratification and the appropria...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-017-0864-8

    authors: Kosova EC,Desai KR,Schimmel DR

    更新日期:2017-06-01 00:00:00

  • Management of combined severe carotid and coronary artery disease.

    abstract::Patients with severe carotid and coronary disease-especially if they require coronary artery bypass grafting (CABG)-are at high risk of cardiac events and stroke. Carotid revascularization should be considered for patients with symptomatic carotid disease and bilateral severe asymptomatic carotid stenosis. In patients...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-012-0246-1

    authors: Roffi M,Ribichini F,Castriota F,Cremonesi A

    更新日期:2012-04-01 00:00:00

  • Eplerenone: will it have a role in the treatment of acute coronary syndromes?

    abstract::Aldosterone is known to have multiple adverse cardiovascular effects that are reminiscent of but independent from angiotensin II. These effects include endothelial dysfunction, heightened thrombogenicity, inflammation, and reparative fibrosis, and have been described in experimental and human models of aldosterone exc...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-004-0073-0

    authors: Meier DJ,Pitt B,Rajagopalan S

    更新日期:2004-07-01 00:00:00

  • Cardiac Magnetic Resonance Fingerprinting: Technical Developments and Initial Clinical Validation.

    abstract:PURPOSE OF REVIEW:Magnetic resonance imaging (MRI) has enabled non-invasive myocardial tissue characterization in a wide range of cardiovascular diseases by quantifying several tissue specific parameters such as T1, T2, and T2* relaxation times. Simultaneous assessment of these parameters has recently gained interest t...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-019-1181-1

    authors: Cruz G,Jaubert O,Botnar RM,Prieto C

    更新日期:2019-07-27 00:00:00

  • State of the Art of Combined Heart-Lung Transplantation for Advanced Cardiac and Pulmonary Dysfunction.

    abstract::Over the last several decades, significant advances and improvements in care of transplant patients have resulted in markedly improved outcomes. A number of options are available for patients with advanced cardiopulmonary dysfunction requiring transplantation. There is a debate about when isolated heart or isolated lu...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-016-0713-1

    authors: Idrees JJ,Pettersson GB

    更新日期:2016-04-01 00:00:00

  • Management of Blood Pressure in Patients with Glaucoma.

    abstract:PURPOSE OF REVIEW:Ocular perfusion pressure (OPP) is defined as the difference between BP and intraocular pressure (IOP). With low BP comes low OPP and resultant ischemic damage to the optic nerve, leading to glaucoma progression. The purpose of this article is to review the literature on BP as it relates to glaucoma a...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-017-0927-x

    authors: Levine RM,Yang A,Brahma V,Martone JF

    更新日期:2017-09-19 00:00:00

  • Diagnosing and Managing Primary Aldosteronism in Hypertensive Patients: a Case-Based Approach.

    abstract::Primary aldosteronism with a prevalence of 8 % of hypertension and 20 % of pharmacologically resistant hypertension is the most common secondary cause of hypertension. Yet, the diagnosis is missed in the vast majority of patients. Current clinical practice guidelines recommend screening for primary aldosteronism in pa...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-016-0774-1

    authors: Carey RM

    更新日期:2016-10-01 00:00:00

  • Artificial Intelligence and Myocardial Contrast Enhancement Pattern.

    abstract:PURPOSE OF REVIEW:Machine learning (ML) and deep learning (DL) are two important categories of AI algorithms. Nowadays, AI technology has been gradually applied to cardiac magnetic resonance imaging (CMRI), covering the fields of myocardial contrast enhancement (MCE) pattern and automatic ventricular segmentation. This...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-020-01306-0

    authors: Tang F,Bai C,Zhao XX,Yuan WF

    更新日期:2020-07-07 00:00:00