Abstract:
:There has been considerable attention in recent years to the intriguing hypothesis that coronary heart disease and other atherosclerotic diseases may be caused by infection with pathogens such as Chlamydia pneumoniae, Helicobacter pylori, and cytomegalovirus. Supporting this hypothesis are studies that localize bacterial antigens to atherosclerotic plaques and that draw associations of systemic inflammation and chronic infections with coronary disease. Although there are several examples of positive associations of pathogen seropositivity with disease, recent prospective follow-up studies of infection seropositivity have not generally supported these associations. At present, the evidence is insufficient to designate infection as a causal risk factor for coronary heart disease. The results of ongoing larger observational studies and antibiotic treatment trials may yield important information regarding the presence and magnitude of risk, if any, beyond that conferred by established coronary risk factors.
journal_name
Curr Cardiol Repjournal_title
Current cardiology reportsauthors
O'Donnell CJ,Levy Ddoi
10.1007/s11886-000-0082-6keywords:
subject
Has Abstractpub_date
2000-07-01 00:00:00pages
280-7issue
4eissn
1523-3782issn
1534-3170journal_volume
2pub_type
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journal_title:Current cardiology reports
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journal_title:Current cardiology reports
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journal_title:Current cardiology reports
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journal_title:Current cardiology reports
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journal_title:Current cardiology reports
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pub_type: 杂志文章,评审
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更新日期:2020-07-28 00:00:00
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journal_title:Current cardiology reports
pub_type: 杂志文章,评审
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更新日期:2015-11-01 00:00:00
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journal_title:Current cardiology reports
pub_type: 杂志文章,评审
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journal_title:Current cardiology reports
pub_type: 杂志文章,评审
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更新日期:2012-08-01 00:00:00
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更新日期:2013-08-01 00:00:00
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journal_title:Current cardiology reports
pub_type: 已发布勘误
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journal_title:Current cardiology reports
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更新日期:2018-07-10 00:00:00
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更新日期:2016-12-01 00:00:00
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更新日期:2015-12-01 00:00:00