Weighing the evidence for infection as a risk factor for coronary heart disease.

Abstract:

:There has been considerable attention in recent years to the intriguing hypothesis that coronary heart disease and other atherosclerotic diseases may be caused by infection with pathogens such as Chlamydia pneumoniae, Helicobacter pylori, and cytomegalovirus. Supporting this hypothesis are studies that localize bacterial antigens to atherosclerotic plaques and that draw associations of systemic inflammation and chronic infections with coronary disease. Although there are several examples of positive associations of pathogen seropositivity with disease, recent prospective follow-up studies of infection seropositivity have not generally supported these associations. At present, the evidence is insufficient to designate infection as a causal risk factor for coronary heart disease. The results of ongoing larger observational studies and antibiotic treatment trials may yield important information regarding the presence and magnitude of risk, if any, beyond that conferred by established coronary risk factors.

journal_name

Curr Cardiol Rep

authors

O'Donnell CJ,Levy D

doi

10.1007/s11886-000-0082-6

keywords:

subject

Has Abstract

pub_date

2000-07-01 00:00:00

pages

280-7

issue

4

eissn

1523-3782

issn

1534-3170

journal_volume

2

pub_type

杂志文章,评审
  • Autonomic Modulation in Heart Failure: Ready for Prime Time?

    abstract::It has been known for many decades that multiple abnormalities of the autonomic nervous system (ANS) are present in heart failure (HF). Moreover, many of the effective therapies currently used to treat HF have either direct or indirect effects on the ANS. While therapies that block over-activity of the sympathetic ner...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-015-0652-2

    authors: Dunlap ME,Bhardwaj A,Hauptman PJ

    更新日期:2015-11-01 00:00:00

  • Overview of the US FDA medical device approval process.

    abstract::Increasing barriers to medical device innovation in the United States including constrained financial resources and rising research costs require that physicians take on greater involvement in medical device development, evaluation, and regulatory processes. Such involvement requires that physicians understand basic a...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-014-0494-3

    authors: Sastry A

    更新日期:2014-01-01 00:00:00

  • Inflammatory markers and stroke.

    abstract::Basic and animal research implicate inflammatory mechanisms in the pathogenesis and progression of atherosclerosis, plaque rupture, thrombosis, and stroke. Inflammatory biomarkers, particularly high-sensitivity C-reactive protein and lipoprotein-associated phospholipase A2, have been identified as potential predictors...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-009-0003-2

    authors: Elkind MS

    更新日期:2009-01-01 00:00:00

  • Artificial Intelligence and Myocardial Contrast Enhancement Pattern.

    abstract:PURPOSE OF REVIEW:Machine learning (ML) and deep learning (DL) are two important categories of AI algorithms. Nowadays, AI technology has been gradually applied to cardiac magnetic resonance imaging (CMRI), covering the fields of myocardial contrast enhancement (MCE) pattern and automatic ventricular segmentation. This...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-020-01306-0

    authors: Tang F,Bai C,Zhao XX,Yuan WF

    更新日期:2020-07-07 00:00:00

  • Management of Lipid Abnormalities in Patients with Diabetes.

    abstract:PURPOSE OF REVIEW:To describe lipid abnormalities in diabetes, when they occur and the evidence base for lipid management with established and new drugs to prevent diabetes complications. We also discuss how to manage statin intolerance. RECENT FINDINGS:Statins remain first-line therapy in patients with diabetes, thou...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-019-1246-1

    authors: Sillars A,Sattar N

    更新日期:2019-11-22 00:00:00

  • Sex-Related Differences in Dilated Cardiomyopathy with a Focus on Cardiac Dysfunction in Oncology.

    abstract:PURPOSE OF REVIEW:The aim of this report is to describe the main aspects of sex-related differences in non-ischemic dilated cardiomyopathies (DCM), focusing on chemotherapy-induced heart failure (HF) and investigating the possible therapeutic implications and clinical management applications in the era of personalized ...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-020-01377-z

    authors: D'Amario D,Camilli M,Migliaro S,Canonico F,Galli M,Arcudi A,Montone RA,Borovac JA,Crea F,Savarese G

    更新日期:2020-08-08 00:00:00

  • Diagnosing and Managing Primary Aldosteronism in Hypertensive Patients: a Case-Based Approach.

    abstract::Primary aldosteronism with a prevalence of 8 % of hypertension and 20 % of pharmacologically resistant hypertension is the most common secondary cause of hypertension. Yet, the diagnosis is missed in the vast majority of patients. Current clinical practice guidelines recommend screening for primary aldosteronism in pa...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-016-0774-1

    authors: Carey RM

    更新日期:2016-10-01 00:00:00

  • Role of antithrombotic agents in heart failure.

    abstract::Despite a vast body of research on antithrombotic therapy for patients with cardiac disease, there are few clinical settings where robust evidence of their benefit exists. Patients with heart failure often have vascular disease and atrial fibrillation contributing to their poor prognosis. For patients with heart failu...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-012-0266-x

    authors: Cleland JG,Mumtaz S,Cecchini L

    更新日期:2012-06-01 00:00:00

  • Molecular cardiovascular imaging.

    abstract::Imaging with radionuclides has historically played an important role in detection of cardiovascular disease as well as in risk stratification and prognostication. With the growth of molecular biology have come new therapeutic interventions and the requirement for new diagnostic imaging approaches. Noninvasive targeted...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-005-0025-3

    authors: Dobrucki LW,Sinusas AJ

    更新日期:2005-03-01 00:00:00

  • Ischemia and Viability Testing in New-Onset Heart Failure.

    abstract:PURPOSE OF REVIEW:To examine the utility and methods of coronary artery disease (CAD) assessment in patients with new-onset heart failure with reduced ejection fraction (HFrEF) of unclear etiology. Moreover, we sought to review the role and techniques of assessing myocardial viability to guide coronary revascularizatio...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-020-01304-2

    authors: Kassab K,Kattoor AJ,Doukky R

    更新日期:2020-07-06 00:00:00

  • Functional Information in Coronary Artery Disease: The Case of Computed Tomography Myocardial Perfusion.

    abstract:PURPOSE OF REVIEW:To review methodological and logistical aspects of CT myocardial perfusion, current clinical evidence and possible future directions, with specific focus on use in patients with coronary artery disease (CAD). RECENT FINDINGS:CT myocardial perfusion imaging may be performed as an add-on to standard co...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-017-0937-8

    authors: Kofoed KF,Sørgaard MH,Linde JJ

    更新日期:2017-10-25 00:00:00

  • Multivessel coronary bypass grafting without cardiopulmonary support.

    abstract::Coronary artery bypass grafting without the aid of cardiopulmonary bypass (CPB) continues to gain popularity as an alternative to standard techniques of revascularization. CPB with cardioplegic arrest is associated with complications that may negate an otherwise technically flawless procedure. Experience has identifie...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-999-0056-2

    authors: Dewey TM,Mack MJ

    更新日期:1999-11-01 00:00:00

  • TAVR in Patients with Pure Aortic Regurgitation: Ready to Use?

    abstract:PURPOSE OF THE REVIEW:Moderate or severe aortic regurgitation (AR) occurs in 0.5% of the population and typically peaks in the fourth to sixth decade of life. A significant proportion of patients have prohibitive surgical risk and are therefore treated medically with pharmacological management of heart failure and no d...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-020-01338-6

    authors: Markham R,Ghodsian M,Sharma R

    更新日期:2020-07-28 00:00:00

  • Prognostic and Therapeutic Implications of Frailty in Older Adults with Heart Failure.

    abstract::Frailty is increasingly recognized in older adults with cardiovascular disease, particularly in those with heart failure (HF). A growing body of evidence has shown that frailty has a negative effect on survival, hospitalizations, disability, and quality of life. Beyond frailty, additional domains captured by a compreh...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-015-0651-3

    authors: Goldfarb M,Sheppard R,Afilalo J

    更新日期:2015-11-01 00:00:00

  • Spontaneous Coronary Artery Dissection.

    abstract::Spontaneous coronary artery dissection is an important etiology of nonatherosclerotic acute coronary syndrome, myocardial infarction, and sudden death. Innovations in the catheterization laboratory including optical coherence tomography and intravascular ultrasound have enhanced the ability to visualize intimal disrup...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-016-0737-6

    authors: Tweet MS,Gulati R,Hayes SN

    更新日期:2016-07-01 00:00:00

  • Which antithrombin for whom? Identifying the patient population that benefits most from novel antithrombin agents.

    abstract::Anticoagulation has proven to be a key component in the management of acute coronary syndromes (ACS). Pharmacological agents with various modes of action are utilized to reduce thrombus development by impairing thrombin formation, platelet activation, and platelet aggregation. The optimal management of these patients ...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-012-0286-6

    authors: Burke DA,Warraich HJ,Pinto DS

    更新日期:2012-08-01 00:00:00

  • The need for combination drug therapies in patients with complex dyslipidemia.

    abstract::Statins are first line therapy for the prevention of cardiovascular disease (CVD). Only 30 %-70 % of high risk patients will attain standard low-density lipoprotein cholesterol targets. Patients with familial hypercholesterolemia and genetic mixed hyperlipidemias do not meet goals with standard therapy. Patients with ...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-013-0391-1

    authors: Barnett J,Viljoen A,Wierzbicki AS

    更新日期:2013-08-01 00:00:00

  • Is There Currently a Place for Combined Mitral and Aortic Transcatheter Interventions?

    abstract:PURPOSE OF REVIEW:The goal was to evaluate published data on the incidence, diagnosis, and management of symptomatic combined mitral and aortic valvular disease. Furthermore, to identify the role of treatment using contemporary transcatheter techniques. RECENT FINDINGS:Up to a quarter of symptomatic adult valvular dis...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-019-1205-x

    authors: De Palma R,O'Sullivan CJ,Settergren M

    更新日期:2019-09-13 00:00:00

  • Most Promising Therapies in Interventional Cardiology.

    abstract:PURPOSE OF REVIEW:The last 40 years of clinical research in interventional cardiology were extraordinarily innovative. This article will review the most promising up and coming interventional cardiovascular therapies, with a primary focus on the treatment of coronary artery disease. RECENT FINDINGS:From the first sten...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-019-1108-x

    authors: Kerneis M,Nafee T,Yee MK,Kazmi HA,Datta S,Zeitouni M,Afzal MK,Jafarizade M,Walia SS,Qamar I,Pitliya A,Kalayci A,Al Khalfan F,Gibson CM

    更新日期:2019-03-13 00:00:00

  • Coronary Artery Anomalies: When You Need to Worry.

    abstract:PURPOSE OF REVIEW:There is a broad spectrum of coronary artery anomalies that cardiologists may encounter either incidentally or during evaluation for cardiac symptoms. These anomalies include anomalous coronary arteries arising from the opposite sinus of Valsalva (ACAOS), coronary fistulae, and coronary artery aneurys...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-017-0854-x

    authors: Kochar A,Kiefer T

    更新日期:2017-05-01 00:00:00

  • Correction to: Cardiac Contractility Modulation: an Important Therapy in the Treatment of Advanced Heart Failure.

    abstract::The article title in the original publication contains a mistake. ...

    journal_title:Current cardiology reports

    pub_type: 已发布勘误

    doi:10.1007/s11886-020-01403-0

    authors: Edelson JB,Genuardi MV,Santangeli P,Birati EY

    更新日期:2020-09-08 00:00:00

  • Safety and efficacy of nesiritide for acute decompensated heart failure: recent literature and upcoming trials.

    abstract::Congestive heart failure is increasing in prevalence in the United States, and associated morbidity and mortality remain high. Aggressive treatment of decompensated heart failure is associated with improved outcomes; however, therapies must be tailored to the presenting characteristics of each patient and most carry a...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/BF02938348

    authors: Hiestand B,Abraham WT

    更新日期:2007-05-01 00:00:00

  • The potential role of iodine-123 metaiodobenzylguanidine imaging for identifying sustained ventricular tachycardia in patients with cardiomyopathy.

    abstract::Implantable cardioverter-defibrillators (ICDs) significantly reduce mortality in patients with depressed left ventricular ejection fraction (LVEF) and heart failure (HF). However, shortcomings of LVEF to accurately identify those at greatest risk of ventricular tachyarrhythmias have led to the pursuit of alternative m...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-013-0359-1

    authors: Klein T,Dilsizian V,Cao Q,Chen W,Dickfeld TM

    更新日期:2013-05-01 00:00:00

  • Appropriateness of percutaneous coronary intervention: a review.

    abstract::The appropriateness of coronary revascularization for various clinical scenarios has been reviewed formally by several specialty and subspecialty societies resulting in the formulation of scored appropriateness criteria. The goal of the appropriateness criteria is to guide physician decision-making and future research...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-013-0379-x

    authors: Summers MR,Patel MR

    更新日期:2013-07-01 00:00:00

  • Catheter ablation of ventricular tachycardia related to coronary artery disease: the role of noncontact mapping.

    abstract::There are a number of limitations associated with conventional mapping for ablation of ventricular tachycardia (VT) in ischemic heart disease, such as the high recurrence rates after initially successful ablation. The development of a noncontact mapping system capable of producing high-resolution isopotential maps of ...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-000-0038-x

    authors: Chow AW,Schilling RJ,Peters NS,Davies DW

    更新日期:2000-11-01 00:00:00

  • Hypertension in black patients: special issues and considerations.

    abstract::The excess risk of hypertension in black Americans continues to be a major health concern. Although there is considerable information regarding these disease trends, much of the major underpinnings of the etiology of hypertension remain unclear. The excess mortality in blacks due to heart disease, renal failure, and s...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-004-0048-1

    authors: Nesbitt SD

    更新日期:2004-11-01 00:00:00

  • Cardiovascular Risk Assessment in Patients with Hypertriglyceridemia.

    abstract:PURPOSE OF REVIEW:Assessing the cardiovascular risk associated with hypertriglyceridemia can be challenging due to frequent confounding conditions such as hypertension, diabetes mellitus, and hyperlipidemia. We sought to quantify this risk by examining several meta-analyses as well as subgroup analyses of previously pu...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-018-1013-8

    authors: Evans MC,Stalam T,Miller M

    更新日期:2018-07-10 00:00:00

  • Treatment of Functional Mitral Regurgitation in Heart Failure.

    abstract:PURPOSE OF REVIEW:To analyze the current state of the art of functional mitral regurgitation (FMR) treatment. RECENT FINDINGS:The first-line treatment of severe FMR consists of guideline medical therapy (GMT) and resynchronization therapy when indicated; the impact of new medical therapies like sacubitril/valsartan ne...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-019-1221-x

    authors: Fabris E,De Luca A,Vitrella G,Stolfo D,Masè M,Korcova R,Merlo M,Rakar S,Van't Hof AWJ,Kedhi E,Perkan A,Sinagra G

    更新日期:2019-11-16 00:00:00

  • Genetic Risk Factors for Ischemic and Hemorrhagic Stroke.

    abstract::Understanding the genetic risk factors for stroke is an essential step to decipher the underlying mechanisms, facilitate the identification of novel therapeutic targets, and optimize the design of prevention strategies. A very small proportion of strokes are attributable to monogenic conditions, the vast majority bein...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-016-0804-z

    authors: Chauhan G,Debette S

    更新日期:2016-12-01 00:00:00

  • Management of Hypertension in Children and Adolescents.

    abstract::Hypertension in children and adolescents is becoming a greater problem in the developed world. Although traditionally thought of as usually secondary to renal, vascular, or endocrine causes, primary hypertension is becoming the most common form seen in childhood. This changing epidemiology is related to the recent obe...

    journal_title:Current cardiology reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11886-015-0661-1

    authors: Samuels J,Bell C,Samuel J,Swinford R

    更新日期:2015-12-01 00:00:00