Abstract:
:We develop a theoretical description of sperm chemotaxis. Sperm cells of many species are guided to the egg by chemoattractants, a process called chemotaxis. Motor proteins in the flagellum of the sperm generate a regular beat of the flagellum, which propels the sperm in a fluid. In the absence of a chemoattractant, sperm swim in circles in two dimensions and along helical paths in three dimensions. Chemoattractants stimulate a signaling system in the flagellum, which regulates the motors to control sperm swimming. Our theoretical description of sperm chemotaxis in two and three dimensions is based on a generic signaling module that regulates the curvature and torsion of the swimming path. In the presence of a chemoattractant, swimming paths are drifting circles in two dimensions and deformed helices in three dimensions. The swimming paths can be described by a dynamical system that exhibits different dynamic regimes, which correspond to different chemotactic behaviours. We conclude that sampling a concentration field of chemoattractant along circular and helical swimming paths is a robust strategy for chemotaxis that works reliably for a vast range of parameters.
journal_name
Proc Natl Acad Sci U S Aauthors
Friedrich BM,Jülicher Fdoi
10.1073/pnas.0703530104subject
Has Abstractpub_date
2007-08-14 00:00:00pages
13256-61issue
33eissn
0027-8424issn
1091-6490pii
0703530104journal_volume
104pub_type
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