Linkage disequilibrium analysis of chromosomal inversion polymorphisms of Drosophila.

abstract：:The nucleotide sequences encoding the mature portion of 31 ribulose 1.5-bisphosphate carboxylase small subunit (SSU) genes from 17 genera of plants, green algae and cyanobacteria were examined. Among the 465 pairwise sequence comparisons, SSU multigene family members within the same species were more similar to each o...

journal_title：Genetics

authors： Meagher RB,Berry-Lowe S,Rice K

更新日期：1989-12-01 00:00:00

abstract：:There has been considerable debate on the geographic origin of the human Y chromosome Alu polymorphism (YAP). Here we report a new, very rare deep-rooting haplogroup within the YAP clade, together with data on other deep-rooting YAP clades. The new haplogroup, found so far in only five Nigerians, is the least-derived ...

journal_title：Genetics

authors： Weale ME,Shah T,Jones AL,Greenhalgh J,Wilson JF,Nymadawa P,Zeitlin D,Connell BA,Bradman N,Thomas MG

更新日期：2003-09-01 00:00:00

abstract：:Thyroid hormone has pleiotropic effects on cochlear development, and genomic variation influences the severity of associated hearing deficits. DW/J-Pou1f1dw/dw mutant mice lack pituitary thyrotropin, which causes severe thyroid hormone deficiency and profound hearing impairment. To assess the genetic complexity of pro...

journal_title：Genetics

authors： Fang Q,Longo-Guess C,Gagnon LH,Mortensen AH,Dolan DF,Camper SA,Johnson KR

更新日期：2011-10-01 00:00:00

abstract：:Additive genetic variance in natural populations is commonly estimated using mixed models, in which the covariance of the genetic effects is modeled by a genetic similarity matrix derived from a dense set of markers. An important but usually implicit assumption is that the presence of any nonadditive genetic effect in...

journal_title：Genetics

authors： Kruijer W

更新日期：2016-01-01 00:00:00

abstract：:A sib analysis of adult life-history characters was performed on about twelve hundred females from a laboratory Drosophila melanogaster population that had been sampled from nature and cultured so as to preserve its genetic variability. The following results were found. There was no detectable trend with age in additi...

journal_title：Genetics

authors： Rose MR,Charlesworth B

更新日期：1981-01-01 00:00:00

abstract：:Dna2 is a nuclease and helicase that functions redundantly with other proteins in Okazaki fragment processing, double-strand break resection, and checkpoint kinase activation. Dna2 is an essential enzyme, required for yeast and mammalian cell viability. Here, we report that numerous mutations affecting the DNA damage ...

journal_title：Genetics

authors： Markiewicz-Potoczny M,Lisby M,Lydall D

更新日期：2018-05-01 00:00:00

abstract：:For most common diseases with heritable components, not a single or a few single-nucleotide polymorphisms (SNPs) explain most of the variance for these disorders. Instead, much of the variance may be caused by interactions (epistasis) among multiple SNPs or interactions with environmental conditions. We present a new ...

journal_title：Genetics

authors： Albrechtsen A,Castella S,Andersen G,Hansen T,Pedersen O,Nielsen R

更新日期：2007-06-01 00:00:00

abstract：:Immature spermatids from Caenorhabditis elegans are stimulated by an external activation signal to reorganize their membranes and cytoskeleton to form crawling spermatozoa. This rapid maturation, termed spermiogenesis, occurs without any new gene expression. To better understand this signal transduction pathway, we is...

journal_title：Genetics

authors： Muhlrad PJ,Ward S

更新日期：2002-05-01 00:00:00

abstract：:Genomic resources for hundreds of species of evolutionary, agricultural, economic, and medical importance are unavailable due to the expense of well-assembled genome sequences and difficulties with multigenerational studies. Teleost fish provide many models for human disease but possess anciently duplicated genomes th...

journal_title：Genetics

authors： Amores A,Catchen J,Ferrara A,Fontenot Q,Postlethwait JH

更新日期：2011-08-01 00:00:00

abstract：:Crossover interference in meiosis is often modeled via stationary renewal processes. Here we consider a new model to incorporate the known biological feature of "obligate chiasma" whereby in most organisms each bivalent almost always has at least one crossover. The initial crossover is modeled as uniformly distributed...

journal_title：Genetics

authors： Falque M,Mercier R,Mézard C,de Vienne D,Martin OC

更新日期：2007-07-01 00:00:00

abstract：:The early steps of symbiotic nodule formation by Rhizobium on plants require coordinate expression of several nod gene operons, which is accomplished by the activating protein NodD. Three different NodD proteins are encoded by Sym plasmid genes in Rhizobium meliloti, the alfalfa symbiont. NodD1 and NodD2 activate nod ...

journal_title：Genetics

authors： Swanson JA,Mulligan JT,Long SR

更新日期：1993-06-01 00:00:00

abstract：:Parameters of continuous distributions of effects and rates of spontaneous mutation for relative viability in Drosophila are estimated by maximum likelihood from data of two published experiments on accumulation of mutations on protected second chromosomes. A model of equal mutant effects gives a poor fit to the data ...

journal_title：Genetics

authors： Keightley PD

更新日期：1994-12-01 00:00:00

abstract：:A system for genetic analysis in the cellular slime mold P. violaceum has been developed. Two growth-temperature-sensitive mutants were isolated in a haploid strain and used to select rare diploid heterozygotes arising by spontaneous fusion of the haploid cells. A recessive mutation to cycloheximide resistance in one ...

journal_title：Genetics

authors： Warren AJ,Warren WD,Cox EC

更新日期：1976-05-01 00:00:00

abstract：:Because some metabolic intermediates are involved in more than one pathway, crosstalk between pathways is crucial to maintaining homeostasis. AMP and histidine biosynthesis pathways are coregulated at the transcriptional level in response to adenine availability. 5'-Phosphoribosyl-4-carboxamide-5-aminoimidazole (AICAR...

journal_title：Genetics

authors： Rébora K,Laloo B,Daignan-Fornier B

更新日期：2005-05-01 00:00:00

abstract：:The type of variegation of eyes of white-mottled mutants of D. hydei, either small-spotted or large-spotted, depends on the specific chromosome rearrangement involved. This distinction between mutants, though handsome, is not absolute because very seldomly small-spotted types do show a larger pigment aggregate and som...

journal_title：Genetics

authors： van Breugel FM

更新日期：1973-10-01 00:00:00

abstract：:Statistical associations between phenotypic traits often result from shared developmental processes and include both covariation between the trait values and more complex associations between higher moments of the joint distribution of traits. In this article, an analytical technique for calculating the covariance bet...

journal_title：Genetics

authors： Rice SH

更新日期：2004-01-01 00:00:00

abstract：:As millions of single-nucleotide polymorphisms (SNPs) have been identified and high-throughput genotyping technologies have been rapidly developed, large-scale genomewide association studies are soon within reach. However, since a genomewide association study involves a large number of SNPs it is therefore nearly impo...

journal_title：Genetics

authors： Zhao J,Jin L,Xiong M

更新日期：2006-11-01 00:00:00

abstract：:Birds are characterized by female heterogamety; females carry the Z and W sex chromosomes, while males have two copies of the Z chromosome. We suggest here that full differentiation of the Z and W sex chromosomes of birds did not take place until after the split of major contemporary lineages, in the late Cretaceous. ...

journal_title：Genetics

authors： Ellegren H,Carmichael A

更新日期：2001-05-01 00:00:00

abstract：:The nonparametric bootstrap approach is known to be suitable for calculating central confidence intervals for the locations of quantitative trait loci (QTL). However, the distribution of the bootstrap QTL position estimates along the chromosome is peaked at the positions of the markers and is not tailed equally. This ...

journal_title：Genetics

authors： Bennewitz J,Reinsch N,Kalm E

更新日期：2002-04-01 00:00:00

abstract：:Mutants arising spontaneously from sporulated cultures of certain strains of yeast, Saccharomyces cerevisiae, contained deletions of the CYC1 gene which controls the primary structure of iso-1-cytochrome c. At least 60 different kinds of deletions were uncovered among the 104 deletions examined and these ranged in len...

journal_title：Genetics

authors： Sherman F,Jackson M,Liebman SW,Schweingruber AM,Stewart JW

更新日期：1975-09-01 00:00:00

abstract：:The uaY gene encodes the transcriptional activator of purine catabolism genes in Aspergillus nidulans. uaY12 results in strongly defective growth on purines as nitrogen sources and in strongly diminished transcription of UaY-regulated genes. This mutation introduces an ATG codon 64 bp upstream of the uaY ATG, generati...

journal_title：Genetics

authors： Oestreicher N,Scazzocchio C

更新日期：2009-04-01 00:00:00

abstract：:Translation of the chloroplast psbC mRNA in the unicellular eukaryotic alga Chlamydomonas reinhardtii is controlled by interactions between its 547-base 5' untranslated region and the products of the nuclear loci TBC1, TBC2, and possibly TBC3. In this study, a series of site-directed mutations in this region was gener...

journal_title：Genetics

authors： Zerges W,Auchincloss AH,Rochaix JD

更新日期：2003-03-01 00:00:00

abstract：:Individual inbreeding and historical demography can be estimated by analyzing runs of homozygosity (ROH), which are indicative of chromosomal segments of identity by descent (IBD). Such analyses have so far been rare in natural populations due to limited genomic resources. We analyzed ROH in whole genome sequences fro...

journal_title：Genetics

authors： Kardos M,Qvarnström A,Ellegren H

更新日期：2017-03-01 00:00:00

abstract：:We examined the prevalence of interactions between pairs of short chromosomal regions from one species (Solanum habrochaites) co-introgressed into a heterospecific genetic background (Solanum lycopersicum). Of 105 double introgression line (DIL) families generated from a complete diallele combination of 15 chromosomal...

journal_title：Genetics

authors： Moyle LC,Nakazato T

更新日期：2009-01-01 00:00:00

abstract：:The mak7-1 mutant loses the killer toxin-encoding M1 dsRNA. MAK7 is RPL4A, one of two genes encoding ribosomal protein L4. KRB1 is a dominant suppressor of mak7-1 that is tightly centromerelinked, but not linked to centromere markers of chromosomes I-XVI. Our orthogonal field agarose gel electrophoresis analysis of ch...

journal_title：Genetics

authors： Ohtake Y,Wickner RB

更新日期：1995-05-01 00:00:00

abstract：:Cell differentiation in yeast species is controlled by a reversible, programmed DNA-rearrangement process called mating-type switching. Switching is achieved by two functionally similar but structurally distinct processes in the budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe In ...

journal_title：Genetics

authors： Hanson SJ,Wolfe KH

更新日期：2017-05-01 00:00:00

abstract：:We previously isolated a pollen factor, ui6.1, which encodes a Cullin1 protein (CUL1) that functions in unilateral interspecific incompatibility (UI) in Solanum. Here we show that CUL1 is also required for pollen function in self-incompatibility (SI). We used RNA interference (RNAi) to reduce CUL1 expression in pollen...

journal_title：Genetics

authors： Li W,Chetelat RT

更新日期：2014-02-01 00:00:00

abstract：:Centromeres control chromosome inheritance in eukaryotes, yet their DNA structure and primary sequence are hypervariable. Most animals and plants have megabases of tandem repeats at their centromeres, unlike yeast with unique centromere sequences. Centromere function requires the centromere-specific histone CENH3 (CEN...

journal_title：Genetics

authors： Ravi M,Kwong PN,Menorca RM,Valencia JT,Ramahi JS,Stewart JL,Tran RK,Sundaresan V,Comai L,Chan SW

更新日期：2010-10-01 00:00:00

abstract：:fl(2)d, the Drosophila homolog of Wilms'-tumor-1-associated protein (WTAP), regulates the alternative splicing of Sex-lethal (Sxl), transformer (tra), and Ultrabithorax (Ubx). Although WTAP has been found in functional human spliceosomes, exactly how it contributes to the splicing process remains unknown. Here we atte...

journal_title：Genetics

authors： Penn JK,Graham P,Deshpande G,Calhoun G,Chaouki AS,Salz HK,Schedl P

更新日期：2008-02-01 00:00:00

abstract：:Sex differences occur in most species and affect a variety of biological traits including morphology, behavior, and life history. The nematode Caenorhabditis elegans exists as a population of self-fertile hermaphrodites with occasional males, which differ anatomically and behaviorally from hermaphrodites. Here we show...

journal_title：Genetics

authors： van den Berg MC,Woerlee JZ,Ma H,May RC

更新日期：2006-06-01 00:00:00