Abstract:
:Regulation of proliferation and differentiation in keratinocyte is a complex and dynamic process that involves activation of multiple signaling pathways triggered by different growth factors. Keratinocyte growth factor (KGF) is not only a potent mitogen, but differently from other growth factors, is a potent inducer of differentiation. The MAP kinase and AKT pathways are involved in proliferation and differentiation of many cell types including keratinocytes. We investigated here the role of KGF in modulating AKT and MAPK activity during differentiation of human keratinocytes. Our results show that the mechanisms of action of KGF are dose-dependent and that a sustained activation of the MAPK signaling cascade causes a negative regulation of AKT. We also demostrated increasing expression of KGFR substrates, such as PAK4 during keratinocyte differentiation parallel to the receptor upregulation.
journal_name
J Cell Physioljournal_title
Journal of cellular physiologyauthors
Lotti LV,Rotolo S,Francescangeli F,Frati L,Torrisi MR,Marchese Cdoi
10.1002/jcp.21056subject
Has Abstractpub_date
2007-09-01 00:00:00pages
633-42issue
3eissn
0021-9541issn
1097-4652journal_volume
212pub_type
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