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Invertebrate animal models of diseases as screening tools in drug discovery.

Abstract：

:Invertebrate animal models (mainly the nematode Caenorhabditis elegans and the fruit fly Drosophila melanogaster) are gaining momentum as screening tools in drug discovery. These organisms combine genetic amenability, low cost, and culture conditions compatible with large-scale screens. Their main advantage is to allow high-throughput screening in a physiological context. On the down side, protein divergence between invertebrates and humans causes a high rate of false negatives. Despite important limitations, invertebrate models are an imperfect yet much needed tool to bridge the gap between traditional in vitro and preclinical animal assays.

journal_name

ACS Chem Biol

journal_title

ACS chemical biology

authors

Ségalat L

doi

10.1021/cb700009m

subject

Has Abstract

pub_date

2007-04-24 00:00:00

pages

231-6

issue

4

eissn

1554-8929

issn

1554-8937

journal_volume

2

pub_type

杂志文章,评审

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