Abstract:
:Semi quantitative MRI is a very useful procedure for evaluating the bone marrow burden (BMB) in Gaucher disease (GD). Score systems have been applied to obtain a parameter for evaluating the severity of bone disease. Our purpose was to test a simple, reproducible and accurate score to evaluate bone marrow involvement in GD patients. MRI was performed in spine, pelvis and femora at diagnosis in 54 adult GD1 patients, 61.1% of whom were female. Three MRI patterns and punctuation in each location were defined: normal, 0; non-homogeneous infiltration subtypes reticular, 1; mottled, 2; diffuse, 3; and homogeneous infiltration, 4. This score was called Spanish-MRI (S-MRI). Two independent observers applied the S-MRI and bone marrow burden score and compared the differences using the non-parametric Mann-Whitney test. Correlation rank test was calculated. In 46 patients (85.2%), bone involvement was observed. Thirty-nine (72.3%) had their spine affected, 35 (64.8%) pelvis and 33 (61.2%) femora. Fourteen patients had bone infarcts, 14 avascular necrosis, 2 vertebral fractures and 2 bone crises. Correlation analysis between S-MRI and BMB was (r(2)=.675; p=.0001). No evidence of correlation was observed between CT activity and S-MRI nor between CT activity and BMB. We have found a relationship between genotype and bone infiltration according to S-MRI site and complications. S-MRI is a simple method that provides useful information to evaluate bone infiltration and detect silent complications. Our results correlated with the BMB score but offer higher sensitivity, specificity and accuracy for classifying the extent of bone disease.
journal_name
Eur J Radioljournal_title
European journal of radiologyauthors
Roca M,Mota J,Alfonso P,Pocoví M,Giraldo Pdoi
10.1016/j.ejrad.2006.11.024subject
Has Abstractpub_date
2007-04-01 00:00:00pages
132-7issue
1eissn
0720-048Xissn
1872-7727pii
S0720-048X(06)00512-2journal_volume
62pub_type
杂志文章abstract::Hydatid disease is a parasitic disease most commonly caused by Echinococcus granulosus that seldom involves the skeleton and is still common in the countries of the temperate zones. We present an extremely rare case report of a young patient with humeral hydatid disease complicated with extraosseous involvement. Plain...
journal_title:European journal of radiology
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journal_title:European journal of radiology
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journal_title:European journal of radiology
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更新日期:2004-06-01 00:00:00
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journal_title:European journal of radiology
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更新日期:2010-01-01 00:00:00
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journal_title:European journal of radiology
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journal_title:European journal of radiology
pub_type: 杂志文章,随机对照试验
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journal_title:European journal of radiology
pub_type: 杂志文章
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更新日期:1990-03-01 00:00:00
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journal_title:European journal of radiology
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更新日期:2013-04-01 00:00:00
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更新日期:2018-04-01 00:00:00
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journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2006.04.003
更新日期:2006-10-01 00:00:00
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journal_title:European journal of radiology
pub_type: 杂志文章
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更新日期:2012-10-01 00:00:00
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journal_title:European journal of radiology
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更新日期:2012-02-01 00:00:00
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journal_title:European journal of radiology
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journal_title:European journal of radiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1991-09-01 00:00:00
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journal_title:European journal of radiology
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更新日期:2018-11-01 00:00:00
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journal_title:European journal of radiology
pub_type: 杂志文章,评审
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更新日期:2013-07-01 00:00:00
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journal_title:European journal of radiology
pub_type: 杂志文章
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更新日期:2019-08-01 00:00:00
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journal_title:European journal of radiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1993-11-01 00:00:00
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journal_title:European journal of radiology
pub_type: 杂志文章
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更新日期:2013-08-01 00:00:00
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journal_title:European journal of radiology
pub_type: 杂志文章
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更新日期:2016-10-01 00:00:00
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journal_title:European journal of radiology
pub_type: 杂志文章
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更新日期:2014-08-01 00:00:00
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journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2011.03.026
更新日期:2011-08-01 00:00:00