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Investigating the correlation of arterial spin labeling and dynamic contrast enhanced perfusion in primary tumor of nasopharyngeal carcinoma.

Abstract：

PURPOSE:This prospective study aimed to investigate the correlation between two perfusion methods: arterial spin labeling (ASL) and dynamic contrast enhanced (DCE) technique in patients with nasopharyngeal carcinoma (NPC) and to optimize ASL protocol. MATERIALS AND METHODS:Forty-five newly diagnosed NPC patients underwent MR examinations with both 3D pseudo-continuous ASL (pCASL) and DCE-MRI sequences. Tumor blood flow (TBF) derived in pCASL with three post-labeling delay (PLD) times (i.e. 1.0 s, 1.5 s, and 2.0 s) and DCE derived parameters including MaxSlop, contrast enhancement ratio (CER), Initial area under the gadolinium curve (IAUGC), Ktrans, Kep and Ve were measured by two independent observers, and their correlation coefficients were investigated using Spearman test. RESULTS:Inter-observer reproducibility (ICC = 0.931-0.998) was observed to be excellent. Positive correlations between mean, maximum and minimum value of TBFs with different PLDs and DCE-MRI parameters (except Ve) were respectively observed (r = 0.308-0.688, P = 0.000-0.040). CONCLUSION:pCASL may be an alternative method for DCE-MRI in assessing the perfusion level in NPC in the future.

journal_name

Eur J Radiol

journal_title

European journal of radiology

authors

Lin M,Yu X,Luo D,Ouyang H,Xie L,Wu B,Zhou C

doi

10.1016/j.ejrad.2018.09.034

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

222-229

eissn

0720-048X

issn

1872-7727

pii

S0720-048X(18)30349-8

journal_volume

108

pub_type

杂志文章

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