Radiation effects in cultured tumour cells examined by 1H MRS: mobile lipids modulation and proliferative arrest.

Abstract:

:Much attention has been devoted in the past to monitor changes of mobile lipid (ML) (1)H MRS signals in spectra of tumour cells. The purpose of this work is to exploit ML signals to provide information on cell metabolism after irradiation, comparing tumour cells characterised by different radiosensitivity and relating MRS findings to changes in cell proliferation and delays in cell cycle phases. Irradiated HeLa cells present less intense ML signals with respect to controls. The opposite is true for MCF-7 cells. A G(2) arrest is observed for both cell lines after irradiation. In HeLa cells, G(1) decreases and S phase is maintained; a sub G(1) peak is also visible. In MCF-7 cells, G(1) is decreased and S phase is strongly reduced, while no sub G(1) is present. The observed changes in ML are tentatively associated to cell cycle regulation of phospholipid synthesis. Mathematical modelling of ML variations is in progress.

journal_name

Radiat Prot Dosimetry

authors

Grande S,Giovannini C,Luciani AM,Palma A,Rosi A,Sapora O,Viti V,Guidoni L

doi

10.1093/rpd/ncl517

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

202-4

issue

1-4

eissn

0144-8420

issn

1742-3406

pii

ncl517

journal_volume

122

pub_type

杂志文章
  • Characterisation of workplaces with risks of internal exposures: air sampling.

    abstract::The measurement of air samples may be used to assess risks of internal exposures, either by the use of workplace static air samplers (SAS) or personal air samplers (PAS). These measurements need to incorporate information on the physical and chemical nature of the aerosol, and the relationship between the sampled and ...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章,评审

    doi:10.1093/rpd/ncm397

    authors: Roberts GA,Bull RK

    更新日期:2007-01-01 00:00:00

  • BAYESIAN SPECTRUM DECONVOLUTION INCLUDING UNCERTAINTIES AND MODEL SELECTION: APPLICATION TO X-RAY EMISSION DATA USING WINBUGS.

    abstract::Spectrum deconvolution is an important task in ionizing radiation measurements, as the pulse height spectra, or, in general, the measured data from spectrometers or other measuring instruments are usually determined by the convolution of the response function with the fluence spectra. The method presented here for obt...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章

    doi:10.1093/rpd/ncy286

    authors: Behrens R,Reginatto M

    更新日期:2019-12-23 00:00:00

  • The study of activity median aerodynamic diameter using imaging plate technique for assessment of effective dose from radon and its decay products.

    abstract::The indoor workplace environment was evaluated for exposure to radon and its decay products at two Universities in two metropolises of Japan. The mean radon concentrations in Nagoya University (NU) and Hokkaido University (HU) were 16.7 Bq m(-3) and 18.0 Bq m(-3), respectively. Activity median aerodynamic diameter (AM...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章,多中心研究

    doi:10.1093/rpd/ncm221

    authors: Rahman NM,Iida T,Yamazawa H,Yokoyama S,Moriizumi J,Saito F,Ito T

    更新日期:2007-01-01 00:00:00

  • COMPARISON OF DIFFERENT TECHNIQUES FOR EVALUATION OF DOSE DISTRIBUTIONS IN RADIOTHERAPY USING RADIOCHROMIC EBT3 FILMS.

    abstract::In radiotherapy, radiochromic films can be used for verification of delivery of dose distributions calculated by treatment planning systems. The main objective of this work was to compare three different techniques for evaluation of dose distributions for prostate cancer treatment plans using radiochromic EBT3 films. ...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章

    doi:10.1093/rpd/ncz231

    authors: Dufek V,Horakova I,Koniarova I

    更新日期:2019-12-31 00:00:00

  • Screen-film versus digital radiography of sacroiliac joints: evaluation of image quality and dose to patients.

    abstract::The purpose of this paper is to evaluate the image quality and dose to patients in the radiography of sacroiliac joints and to perform a clinical comparative study of digital and conventional screen-film radiography. Routine radiography of sacroiliac joint was performed in 60 patients using digital and screen-film rad...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章

    doi:10.1093/rpd/ncs315

    authors: Jablanovic D,Ciraj-Bjelac O,Damjanov N,Seric S,Radak-Perovic M,Arandjic D,Maksimovic R

    更新日期:2013-06-01 00:00:00

  • Characterization Of A Lanthanum Bromide Detector For Eye Lens Dosimetry At The Candu Nuclear Power Plants Based On Direct Measurements Of The Gamma-Ray Spectra.

    abstract::Gamma-ray spectra were measured using a LaBr$_{3}$(Ce) spectrometer during the outage periods, aiming at quantifying the gamma source term of radiation workers' exposure, at the CANDU nuclear power reactors, for the purposes of eye lens dosimetry. The spectra were measured inside the boiler rooms, of the Bruce Power a...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章

    doi:10.1093/rpd/ncaa186

    authors: Laranjeiro AS,Bohra F,Byun SH,Atanackovic J,Hanu AR

    更新日期:2020-12-15 00:00:00

  • Inter-laboratory test program (PTI) in 'neutron dosimetry'.

    abstract::The Laboratory of External Dosimetry Studies and Researches (LRDE), associated laboratory to the Bureau National de Métrologie, is strongly involved in the reference establishment and calibration of instruments in neutron radiation fields provided by 241Am-Be, 252Cf and (252Cf + D2O)/Cd sources. In 1997, on the reques...

    journal_title:Radiation protection dosimetry

    pub_type: 指南,杂志文章,多中心研究

    doi:10.1093/rpd/nch193

    authors: Van-Ryckeghem L,Pelcot G,Suder F,Bureau National de Métrologie.

    更新日期:2004-01-01 00:00:00

  • Survey of patient dose in computed tomography in Syria 2009.

    abstract::The radiation doses to patient in computed tomography (CT) in Syria have been investigated and compared with similar studies in different countries. This work surveyed 30 CT scanners from six different manufacturers distributed all over Syria. Some of the results in this paper were part of a project launched by the In...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章

    doi:10.1093/rpd/ncq155

    authors: Kharita MH,Khazzam S

    更新日期:2010-09-01 00:00:00

  • Dose and dose rate effectiveness of space radiation.

    abstract::Dose and dose rate effectiveness factors (DDREF), in conjunction with other weighting factors, are commonly used to scale atomic bomb survivor data in order to establish limits for occupational radiation exposure, including radiation exposure in space. We use some well-known facts about the microscopic pattern of ener...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章

    doi:10.1093/rpd/ncl464

    authors: Schimmerling W,Cucinotta FA

    更新日期:2006-01-01 00:00:00

  • Investigation of the emission spectra of LiF:Mg,Ti (TLD-100) during thermoluminescence.

    abstract::The thermoluminescence (TL) of LiF:Mg,Ti has been studied using a high resolution CCD spectrophotometer, which simultaneously measures the emission intensity and the emission spectrum as a function of sample temperature. Computerised deconvolution was used to resolve the emission spectrum into individual Gaussian band...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.rpd.a005891

    authors: Biderman S,Horowitz Y,Oster L

    更新日期:2002-01-01 00:00:00

  • Implications of human nasal clearance studies for the interpretation of nose blow and bioassay sample measurements.

    abstract::The Smith-Etherington extrathoracic (ET) clearance model has been developed to describe clearance from the human nasal passage as observed for 1.5, 3 and 6 microm monodisperse particles inhaled by participants while sitting or at light exercise. Model parameter values have been determined for 22 sets of nasal clearanc...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.rpd.a006205

    authors: Smith JR

    更新日期:2003-01-01 00:00:00

  • DOSIMETRIC PROPERTIES OF THE NEW TLD ALBEDO NEUTRON DOSEMETER AWST-TL-GD 04.

    abstract::A new official albedo dosemeter based on thermoluminescent detectors has been introduced in 2015 by the individual monitoring service of the Helmholtz Zentrum München for monitoring persons who are exposed occupationally against photon and neutron radiation. To enhance the sensitivity for fast neutrons, a new badge wi...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章

    doi:10.1093/rpd/ncv406

    authors: Haninger T,Henniger J

    更新日期:2016-09-01 00:00:00

  • Development of a radon trap device using a corona discharge.

    abstract::Radon is one of the noble gases, which are chemically inert and do not make any reactants under normal conditions. In this experiment we demonstrated an enigmatic reaction between radon and fluorine when a corona discharge is used as a promoter. Distinctive changes in radon concentrations were caused by the discharge ...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章

    doi:10.1093/rpd/nci311

    authors: Yamada Y,Koizumi A,Ishikawa K,Hishinuma Y,Tatenuma K

    更新日期:2005-01-01 00:00:00

  • Plutonium isotopes in marine sediments and some biota from the Sudanese coast of the Red Sea.

    abstract::Measurements of (239+240)Pu and (238)Pu were carried out on marine biota as well as on sediments from the fringing reefs area extending towards north and south (Flamingo Bay) of PortSudan harbour. The analyses were performed using radiochemical separation and alpha spectrometry. The range of the activity concentration...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章

    doi:10.1093/rpd/ncn193

    authors: Sirelkhatim DA,Sam AK,Hassona RK

    更新日期:2008-01-01 00:00:00

  • Secondary neutron doses in proton therapy treatments of ocular melanoma and craniopharyngioma.

    abstract::Monte Carlo simulations were used to assess secondary neutron doses received by patients treated with proton therapy for ocular melanoma and craniopharyngioma. MCNPX calculations of out-of-field doses were done for ∼20 different organs considering realistic treatment plans and using computational phantoms representati...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章

    doi:10.1093/rpd/nct283

    authors: Farah J,Sayah R,Martinetti F,Donadille L,Lacoste V,Hérault J,Delacroix S,Nauraye C,Vabre I,Lee C,Bolch WE,Clairand I

    更新日期:2014-10-01 00:00:00

  • Bremsstrahlung and photoneutron production in a steel shield for 15-22-MeV clinical electron beams.

    abstract::The physical data regarding bremsstrahlung and neutrons produced in a steel shield by high-energy electron beams from a medical linear accelerator were investigated. These data are required to allow the accurate prediction of shielding performance for high-energy electron beams and in the design of radiotherapy facili...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章

    doi:10.1093/rpd/ncu153

    authors: Fujita Y,Myojoyama A,Saitoh H

    更新日期:2015-02-01 00:00:00

  • ORGAN ABSORBED DOSE ESTIMATION REFLECTING SPECIFIC ORGAN MASSES WITH SIMPLE SCALING OF REFERENCE DOSES USING THE ORGAN MASSES.

    abstract::Estimating organ absorbed doses in consideration of person-specific parameters is important for radiation protection in diagnostic nuclear medicine. This study proposes a straightforward method for estimating the organ dose that reflects a specific organ mass by scaling the reference organ dose using the inverse ratio...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章

    doi:10.1093/rpd/ncaa058

    authors: Manabe K,Koyama S

    更新日期:2020-07-24 00:00:00

  • Natural radioactivity levels of geothermal waters and their influence on soil and agricultural activities.

    abstract::All over the world geothermal sources are used for different purposes. The contents of these waters are important to understand positive/negative effects on human life. In this study, natural radioactivity concentrations of geothermal waters were investigated to evaluate the effect on soils and agricultural activities...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章

    doi:10.1093/rpd/nct220

    authors: Murat Saç M,Aydemir S,Içhedef M,Kumru MN,Bolca M,Ozen F

    更新日期:2014-01-01 00:00:00

  • General guidelines for the assessment of internal dose from monitoring data: progress of the IDEAS project.

    abstract::In recent major international intercomparison exercises on intake and internal dose assessments from monitoring data, the results calculated by different participants varied significantly. Based on this experience the need for harmonisation of the procedures has been formulated within an EU 5th Framework Programme res...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章

    doi:10.1093/rpd/ncl132

    authors: Doerfel H,Andrasi A,Bailey M,Blanchardon E,Cruz-Suarez R,Berkovski V,Castellani CM,Hurtgen C,LeGuen B,Malatova I,Marsh J,Stather J,Zeger J

    更新日期:2007-01-01 00:00:00

  • THE CONVERSION OF EXPOSURES DUE TO RADON INTO THE EFFECTIVE DOSE TAKING INTO ACCOUNT THE EQUIVALENCE OF RISKS FROM SHORT- AND LONG-TERM EXPOSURES.

    abstract::The theoretical basis for comparing risks from short- and long-term exposures is developed aiming at implementing long-term exposures into a unique and consistent system of radiation protection. Based on system-analytical considerations, the equivalence of population-averaged risk rates due to prolonged exposures and ...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章

    doi:10.1093/rpd/ncv553

    authors: Beck TR

    更新日期:2016-12-01 00:00:00

  • A study of the irradiation temperature coefficient for L-alanine and DL-alanine dosemeters.

    abstract::Alanine dosimetry is now well established both as a reference and routine dosemeter for industrial irradiation processing. Accurate dosimetry under the relatively harsh conditions of industrial processing requires a characterisation of the parameters that influence the dosemeter response. The temperature of the doseme...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章

    doi:10.1093/rpd/nci543

    authors: Desrosiers MF,Lin M,Cooper SL,Cui Y,Chen K

    更新日期:2006-01-01 00:00:00

  • A large-scale measurement, analysis and modelling of electromagnetic radiation levels in the vicinity of GSM/UMTS base stations in an urban area.

    abstract::The present study analyses the electric field radiating from the GSM/UMTS base stations located in central Malatya, a densely populated urban area in Turkey. The authors have conducted both instant and continuous measurements of high-frequency electromagnetic fields throughout their research by using non-ionising radi...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章

    doi:10.1093/rpd/ncv008

    authors: Karadağ T,Yüceer M,Abbasov T

    更新日期:2016-01-01 00:00:00

  • Assessment of effective dose in paediatric CT examinations.

    abstract::Current concerns focus on the high doses encountered in computed tomography (CT) examinations as they are extending towards younger and more radiosensitive patients. Previous work produced conversion coefficients for effective dose (E) from dose-length product (DLP) for four anatomical body regions applicable to any p...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章

    doi:10.1093/rpd/ncr288

    authors: Dougeni E,Chapple CL,Willis J,Panayiotakis G

    更新日期:2011-09-01 00:00:00

  • Dose surveys and DRLs: critical look and way forward.

    abstract::The main purpose of dose surveys has been to detect and bring down wide variation in radiation doses for any particular radiological examination and to avoid doses that are on higher side. Diagnostic reference levels (DRLs) have been used for over two decades as an aid in this objective. With very limited success that...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章

    doi:10.1093/rpd/ncv063

    authors: Rehani MM

    更新日期:2015-07-01 00:00:00

  • Multileaf shielding design against neutrons produced by medical linear accelerators.

    abstract::This work aims at presenting a study using Monte Carlo simulation of a Multileaf Shielding (MLS) System designed to be used for the protection of patients who undergo radiotherapy treatment, against undesired exposure to neutrons produced in the components of the medical linear accelerator heads. The choice of radioth...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章

    doi:10.1093/rpd/ncm312

    authors: Rebello WF,Silva AX,Facure A

    更新日期:2008-01-01 00:00:00

  • DOSE AREA PRODUCT VALUES OF FLUOROSCOPICALLY GUIDED PAIN MANAGEMENT PROCEDURES: COMPARISON OF A BELGIAN TEACHING HOSPITAL WITH NATIONAL DIAGNOSTIC REFERENCE LEVELS.

    abstract::In 2011, national diagnostic reference levels (DRLs) were proposed for pain management fluoroscopic procedures in Belgium. The primary goal of this work is to compare the dose area product values (DAP) recorded at the Saint-Luc University Hospital to these DRLs. From 2012 to 2015, 7664 interventional pain management p...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章

    doi:10.1093/rpd/ncx271

    authors: Hustinx N,Steyaert A,le Polain de Waroux B,Forget P

    更新日期:2018-05-01 00:00:00

  • Set-up of a passive Bonner sphere system for neutron spectrometry at mixed fields with predominant photon component based on activation detector.

    abstract::A passive Bonner sphere system (BSS), based on thermal neutron activation detectors, was developed to perform neutron spectrometry in pulsed and very intense (n-gamma) fields with predominant photon component, as those produced by high energy (>10 MV) medical linear electron accelerators. In this paper, a description ...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章

    doi:10.1093/rpd/ncm070

    authors: Amgarou K,Lacoste V,Muller H,Fernández F

    更新日期:2007-01-01 00:00:00

  • EFFECTIVE INDOOR DOSE OF GAMMA RADIATION FROM BUILDING MATERIALS: COMPARISON OF SEVERAL METHODS FOR ESTIMATION AND POSSIBLE UNDERESTIMATE.

    abstract::This paper compares several methods for estimation of the effective indoor dose of gamma radiation from building materials. It was found that specific dose ratios proposed for 3 cm thick layers in one recommendation gives 2.8 times lower value of gamma dose than other methods. The most common case is that granite has ...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章

    doi:10.1093/rpd/ncaa125

    authors: Krmar M,Milić K,Arsenić I,Hansman J

    更新日期:2020-10-16 00:00:00

  • The in vivo assessment of thorium body burden by gamma ray sepctrometry.

    abstract::Thorium is used in many different industrial technologies and is widely found in nature. Internal contamination with thorium is considered as highly hazardous because of its radiological and chemical toxicities, which depend on the chemical form in which thorium appears. The assessment of the thorium body burden is th...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.rpd.a006656

    authors: Genicot JL,Bruggeman M

    更新日期:2001-01-01 00:00:00

  • Radon in Finnish apartment buildings.

    abstract::The 106 866 dwellings measured for radon in Finland so far by Radiation and Nuclear Safety Authority include 5560 apartments. The radon concentrations in ground-contact apartments are similar to those in low-rise residential buildings located in the same area. The values in apartments above the first floor do not sign...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章

    doi:10.1093/rpd/ncs211

    authors: Valmari T,Arvela H,Reisbacka H

    更新日期:2012-11-01 00:00:00