Radiation effects in cultured tumour cells examined by 1H MRS: mobile lipids modulation and proliferative arrest.


:Much attention has been devoted in the past to monitor changes of mobile lipid (ML) (1)H MRS signals in spectra of tumour cells. The purpose of this work is to exploit ML signals to provide information on cell metabolism after irradiation, comparing tumour cells characterised by different radiosensitivity and relating MRS findings to changes in cell proliferation and delays in cell cycle phases. Irradiated HeLa cells present less intense ML signals with respect to controls. The opposite is true for MCF-7 cells. A G(2) arrest is observed for both cell lines after irradiation. In HeLa cells, G(1) decreases and S phase is maintained; a sub G(1) peak is also visible. In MCF-7 cells, G(1) is decreased and S phase is strongly reduced, while no sub G(1) is present. The observed changes in ML are tentatively associated to cell cycle regulation of phospholipid synthesis. Mathematical modelling of ML variations is in progress.


Radiat Prot Dosimetry


Grande S,Giovannini C,Luciani AM,Palma A,Rosi A,Sapora O,Viti V,Guidoni L




Has Abstract


2006-01-01 00:00:00














  • Neutron response of the chlorobenzene-ethanol-trimethylpentane dosimetry system.

    abstract::The dosimetric use of the chemical solution chlorobenzene-ethanol-trimethylpentane (CET) is based on the radiolytic formation of hydrochloric acid, which protonates a pH indicator thymolsulphonphthalein. On the basis of the CET solution, an accident and emergency personal dosemeter was designed allowing doses in the r...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章


    authors: Miljanić S,Razem D

    更新日期:2007-01-01 00:00:00

  • AVIDOS--a software package for European accredited aviation dosimetry.

    abstract::AVIDOS is a computer code used for the dose assessment of aircraft crew exposed to cosmic radiation. The code employs a multiparameter model built upon simulations of cosmic radiation exposure done using the FLUKA Monte Carlo code. AVIDOS calculates both ambient dose equivalent H*(10) and effective dose E for flight r...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章


    authors: Latocha M,Beck P,Rollet S

    更新日期:2009-10-01 00:00:00

  • Characterisation of neutron fields: challenges in assessing the directional distribution.

    abstract::The SCK·CEN has carried out neutron field characterisation campaigns at several nuclear reactors. The main goal of these measurement campaigns was to evaluate the performance of different neutron personal dosemeters. To be able to evaluate the performance of neutron personal dosemeters in terms of Hp(10), knowledge of...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章


    authors: Cauwels V,Vanhavere F,Reginatto M

    更新日期:2014-10-01 00:00:00

  • Early effects comparison of X-rays delivered at high-dose-rate pulses by a plasma focus device and at low dose rate on human tumour cells.

    abstract::A comparative study has been performed on the effects of high-dose-rate (DR) X-ray beams produced by a plasma focus device (PFMA-3), to exploit its potential medical applications (e.g. radiotherapy), and low-DR X-ray beams produced by a conventional source (XRT). Experiments have been performed at 0.5 and 2 Gy doses o...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章


    authors: Virelli A,Zironi I,Pasi F,Ceccolini E,Nano R,Facoetti A,Gavoçi E,Fiore MR,Rocchi F,Mostacci D,Cucchi G,Castellani G,Sumini M,Orecchia R

    更新日期:2015-09-01 00:00:00

  • Optimised geometry to calculate dose rate conversion coefficient for external exposure to photons.

    abstract::A single-parameter geometry to describe soil is achieved for Monte Carlo calculation of absorbed dose rate in air for photon emitters from natural radionuclides. This optimised geometry based on physical assumptions consists of the soil part whose emitted radiation has a given minimum probability to reach the detector...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章


    authors: Askri B,Manai K,Trabelsi A,Baccari B

    更新日期:2008-01-01 00:00:00

  • Minimising activity and dose with enhanced image quality by radiopharmaceutical administrations.

    abstract::Owing to the introduction of new diagnostic procedures, such as computed tomography (CT), positron emission tomography (PET) and single photon emission computed tomography (SPECT), the individual dose caused by medical exposures has grown rapidly in the last years. This is especially a subject to radiation protection ...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章


    authors: Hoeschen C,Mattsson S,Cantone MC,Mikuz M,Lacasta C,Ebel G,Clinthorne N,Giussani A

    更新日期:2010-04-01 00:00:00

  • International intercomparison of measuring instruments for radon/thoron gas and radon short-lived daughter products in the NRPI Prague.

    abstract::During the 7th European Conference on Protection Against Radon at Home and at Work held in the autumn of 2013 in Prague, the second intercomparison of measuring instruments for radon and its short-lived decay products and the first intercomparison of radon/thoron gas discriminative passive detectors in mix field of ra...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章


    authors: Jílek K,Hýža M,Kotík L,Thomas J,Tomášek L

    更新日期:2014-07-01 00:00:00

  • CT equipment and performance issues: radiation protection 162.

    abstract::Since the development of the CT scanner in the early 1970s, CT scanner technology has continuously developed through technical advancement, faster computer processing, superior detectors and helical and multi-detector scanning modes. As a result, the scope of clinical examinations has broadened considerably, and in pa...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章


    authors: Edyvean S

    更新日期:2013-02-01 00:00:00

  • Radon in earthquake prediction research.

    abstract::The observation of anomalies in the radon concentration in soil gas and ground water before earthquakes initiated systematic investigations on earthquake precursor phenomena. The question what is needed for a meaningful earthquake prediction as well as what types of precursory effects can be expected is shortly discus...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章


    authors: Friedmann H

    更新日期:2012-04-01 00:00:00


    abstract::Within the framework of a joint research project on natural radiation exposure and its health effects in Cameroon from 2014 to 2017, the Institute of Geological and Mining Research and the Hirosaki University worked together to carry out natural radiation survey in mining and ore bearing regions of Cameroon. Air kerma...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章


    authors: Tokonami S,Hosoda M,Joseph Emmanuel NNI,Akata N,Flore TSY,Modibo OB,Samuel BG,Didier TSS

    更新日期:2019-10-01 00:00:00

  • Practical application of the ICRP Human Respiratory Tract Model.

    abstract::The ICRP Publication 66 Human Respiratory Tract Model (HRTM) has been applied to calculate dose coefficients and bioassay functions using default values of parameters relating to the material and the subjects. The ICRP Task Group on Internal Dosimetry (INDOS) has developed a guidance document on application of the HRT...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章


    authors: Bailey MR,Ansoborlo E,Guilmette RA,Paquet F

    更新日期:2003-01-01 00:00:00

  • Radiation exposure received by the medical radiation workers in Lithuania at the Institute of Oncology, Vilnius University, 2004-2011.

    abstract::The occupational radiation exposure of medical radiation workers at the Institute of Oncology, Vilnius University (IOVU) was analysed. Quartile dose measurements were collected and routinely analysed for a period of 8 y from 1 January 2004 to 31 December 2011. A total of 193 medical radiation workers were monitored, c...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章


    authors: Samerdokiene V,Atkocius V,Ofomala R

    更新日期:2013-11-01 00:00:00


    abstract::This study aimed to reveal the effect of X-irradiation on mitochondrial function in terms of mitochondrial membrane potential (ΔΨm) and ATP productivity. At the cellular level, ΔΨm was quantified using JC-1, a mitochondrial probe that emits red or green fluorescence at high or low ΔΨm sites, respectively. The fluoresc...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章


    authors: Hamada R,Kaminaga K,Suzuki K,Yokoya A

    更新日期:2019-05-01 00:00:00

  • Dosimetric monitoring in Ukraine--present status and path to the future.

    abstract::Despite wide use of nuclear energy and radiation sources in industry and medicine, there is no centralised dose accounting system in Ukraine; existing dosimetry services operate obsolete manual thermoluminescence dosemeter (TLD) readers and do not meet modern proficiency standards. Currently, dosimetric monitoring is ...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章


    authors: Chumak V,Boguslavskaya A

    更新日期:2007-01-01 00:00:00

  • Intercomparison of patient CTDI surveys in three countries.

    abstract::The results of large-scale computed tomography (CT) patient dose surveys from the USA, UK and Germany undertaken during the period 1999-2001 were reviewed. The mean values for volume-weighted CT dose index (CTDI(vol)) and dose length product (DLP) were extracted. For head CT examinations, the reported values for the t...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章


    authors: Martin CJ,Huda W

    更新日期:2013-01-01 00:00:00

  • Long-term measurements of radon equilibrium factor in Greek dwellings.

    abstract::The time variation of the radon equilibrium factor F was measured every four hours in the Nuclear Technology Laboratory of the Aristotle University of Thessaloniki (in northern Greece) during October 1998-April 1999. The time dependence of the mean weekly value of radon equilibrium factor F is relatively small. During...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章


    authors: Clouvas A,Xanthos S,Antonopoulos-Domis M

    更新日期:2003-01-01 00:00:00


    abstract::This study aims to provide more insight in attenuation characteristics and corresponding lead (Pb) equivalences of a broad range of commercially available lead composite and nonlead protective garments. Thirty garments of five manufacturers (listed as 0.25-0.35-0.50 mm Pb equivalent) were tested. Transmission values w...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章


    authors: Peters SMB,Zweers D,de Lange F,Mourik JEM

    更新日期:2017-08-01 00:00:00

  • Measurement of neutron dose with an organic liquid scintillator coupled with a spectrum weight function.

    abstract::A dose evaluation method for neutrons in the energy range of a few MeV to 100 MeV has been developed using a spectrum weight function (G-function), which is applied to an organic liquid scintillator of 12.7 cm in diameter and 12.7 cm in length. The G-function that converts the pulse height spectrum of the scintillator...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章


    authors: Kim E,Endo A,Yamaguchi Y,Yoshizawa M,Nakamura T

    更新日期:2002-01-01 00:00:00

  • Evaluation Of Organ Dose Based On Patient Data In East Asian Descent Pediatric Head Ct Examinations.

    abstract::The purpose of this study was to investigate other indices estimating absorbed dose for eye lens and brain, using clinical images of East Asian pediatric patients. We simulated head computed tomography (CT ) examinations in 104 pediatric patients. Effective diameter (deff) and water equivalent diameter (dw) were measu...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章


    authors: Kawamoto K,Fukushima Y,Matsuda A,Nakata M

    更新日期:2020-12-17 00:00:00

  • A pilot study of the dependence of radon concentration on the tectonic structures, using simple geophysical methods.

    abstract::It is well known that there are great variations in radon concentrations in the soil gas on building sites. The concentration may sometimes vary by more than two orders of magnitude. The tectonic structure of the bedrock is one of the factors that influence the intensity of the radon outflow. The simple ARES geophysic...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章


    authors: Thinova L,Fronka A,Rovenska K

    更新日期:2011-05-01 00:00:00

  • Physical image quality comparison of four types of digital detector for chest radiology.

    abstract::Image quality for similar exposure conditions has been compared for two computed radiography (CR) systems (needle-based and conventional storage phosphor) and two flat-panel (DR) systems from different manufacturers mainly devoted to chest radiology. Image quality was assessed with a contrast-detail object and acrylic...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章


    authors: Fernandez JM,Ordiales JM,Guibelalde E,Prieto C,Vano E

    更新日期:2008-01-01 00:00:00

  • Assessment of radiation doses to Australian participants in British nuclear tests.

    abstract::Between 1952 and 1957, the UK exploded a total of 12 nuclear devices in Australia, and also conducted about 600 'minor trials' that did not involve a nuclear explosion. Over 16 000 Australian servicemen and civilians were involved in the UK tests in Australia. This paper reports the estimation of doses that the Austra...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章


    authors: Crouch P,Robotham FR,Williams G,Wise K

    更新日期:2009-09-01 00:00:00

  • Head calibration phantoms for actinides: measurements and simulations.

    abstract::The paper deals with the physical skull phantoms Bundesinstitut fuer Strahlenschutz and BPAM-001, which are used in order to calibrate in vivo detection systems for estimation of (241)Am activity in the skeleton. Their voxel models were made and used in the Monte Carlo simulations. The results of the simulation were c...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章


    authors: Vrba T

    更新日期:2011-03-01 00:00:00

  • Energy responses of the LiF series TL pellets to high-energy photons in the energy range from 1.25 to 21 MV.

    abstract::The energy responses for the KLT-300(LiF:Mg,Cu,Na,Si, Korea), GR-200(LiF:Mg,Cu,P, China) and MCP-N(LiF:Mg,Cu,P, Poland) thermoluminescence(TL) pellets were studied for a photon radiation with energies from 1.25 MeV(60Co) to 21 MV (Microtron) to verify the usefulness of the calibration for the radiotherapy beams. The I...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章


    authors: Kim JL,Lee JI,Ji YH,Kim BH,Kim JS,Chang SY

    更新日期:2006-01-01 00:00:00


    abstract::An automatic measuring apparatus called exhalometer for measurement of the radon exhalation rate from soil is introduced. It consists of a pneumatic driven accumulation chamber with an open bottom, a PC-based control system, six Lucas cells for radon measurement and sensors for environmental parameters. It allows movi...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章


    authors: Yang J,Buchsteiner M,Salvamoser J,Irlinger J,Guo Q,Tschiersch J

    更新日期:2017-11-01 00:00:00

  • Indoor concentration of radon, thoron and their progeny around granite regions in the state of Karnataka, India.

    abstract::An extensive studies on the indoor activity concentrations of thoron, radon and their progeny in the granite region in the state of Karnataka, India, has been carried out since, 2007 in the scope of a lung cancer epidemiological study using solid-state nuclear track detector-based double-chamber dosemeters (LR-115, ty...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章


    authors: Sannappa J,Ningappa C

    更新日期:2014-03-01 00:00:00


    abstract::The purpose of the research is to develop an integrated technique for determining the effective dose (E) of external and internal exposure by different sources of ionizing radiation. The proposing technique for determining the total effective dose is based on three methods of calculation. The first one is multiplying ...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章


    authors: Kudryashev VA,Kim DS

    更新日期:2019-12-31 00:00:00

  • WHO's health risk assessment of ELF fields.

    abstract::The World Health Organization (WHO), the International Commission on Non-Ionizing Radiation Protection (ICNIRP), WHO's scientific collaborating centres (including the UK's National Radiological Protection Board (NRPB)) and over 50 participating Member States are participants of WHO's International EMF Project. As part...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章


    authors: Repacholi MH

    更新日期:2003-01-01 00:00:00

  • Dosimetric data and radiation risk analysis for new procedures in interventional cardiology.

    abstract::The purpose of this study was to evaluate radiation doses to the patients and operators during interventional cardiology procedures, with a particular focus on the transcatheter aortic valve implantation (TAVI). Patient doses for 5549 diagnostic and therapeutic procedures and 76 TAVI were examined, as well as occupati...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章


    authors: Signorotto P,del Vecchio A,Montorfano M,Maisano F,Giagnorio M,Bellanca R,Colombo A,Calandrino R

    更新日期:2010-12-01 00:00:00

  • Modelling of composite neutron scintillators.

    abstract::Composite neutron scintillators consisting of neutron-insensitive fluorescent dopant particles (e.g. ZnS:Ag) embedded in a matrix material containing isotopes with high neutron cross sections that emit energetic charged particles (e.g. 6Li) are a popular method for neutron detection in a variety of applications. The s...

    journal_title:Radiation protection dosimetry

    pub_type: 杂志文章


    authors: Stephan AC,Dai S,Wallace SA,Miller LF

    更新日期:2005-01-01 00:00:00