Abstract：
:During early stages of meiotic prophase I the nucleus undergoes considerable reorganization, including the clustering of telomeres, the release of contacts between chromosomes and the nuclear membrane, the reorganization of the nucleolus, and chromatin remodeling. Using a light squashing technique for the analysis of meiotic chromosomes along with fluorescent in situ hybridization, transmission electron microscopy and immunolocalization studies with antibodies to modified histones, we demonstrate that ASK1 is essential for early nuclear reorganization events. A relatively large number of meiotic alterations have been identified in ask1-1 plants. We show that many of these defects, including alterations in homolog pairing, nucleolus migration and the missegregation of chromosomes, may arise from alterations in chromatin structure and the inability of chromosomes to resolve and release properly from the nuclear membrane and nucleolus during leptotene. These results raise the interesting possibility that ASK1 controls chromatin structure by targeting of either an early regulator of meiotic progression or possibly matrix attachment proteins for destruction.
journal_name
J Cell Scijournal_title
Journal of cell scienceauthors
Yang X,Timofejeva L,Ma H,Makaroff CAdoi
10.1242/jcs.03155subject
Has Abstractpub_date
2006-09-15 00:00:00pages
3754-63issue
Pt 18eissn
0021-9533issn
1477-9137pii
jcs.03155journal_volume
119pub_type
杂志文章abstract：:Delayed wound healing caused by inefficient re-epithelialization underlines chronic skin lesions such as those found in diabetes. The dioxin receptor (AhR) modulates cell plasticity and migration and its activation by occupational polycyclic aromatic hydrocarbons (PAHs) results in severe skin lesions such as contact h...
journal_title：Journal of cell science
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abstract：:The Cep63-Cep152 complex located at the mother centriole recruits Plk4 to initiate centriole biogenesis. How the complex is targeted to mother centrioles, however, is unclear. In this study, we show that Cep57 and its paralog, Cep57l1, colocalize with Cep63 and Cep152 at the proximal end of mother centrioles in both c...
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journal_title：Journal of cell science
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更新日期：2004-07-01 00:00:00
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更新日期：2003-01-01 00:00:00
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journal_title：Journal of cell science
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更新日期：2019-11-08 00:00:00
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更新日期：2002-02-15 00:00:00
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更新日期：1998-10-01 00:00:00
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更新日期：2009-11-15 00:00:00
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