Abstract:
:The hepatic and splenic storage iron, including the relative distribution between ferritin and haemosiderin, was estimated in 130 necropsies including normal accident cases and cases with a variety of diseases. The storage iron was also examined histochemically. It was found that in the normal subjects, on the average, approximately 400 mg. of iron was stored in these two organs, somewhat more than half being present as ferritin iron. Increased storage iron was found in some cases of infection, malignancy, and in blood and hepatic diseases, while low stores were present in other cases with malignancy and in polycythaemia vera. Although there was a slight tendency in infections and malignant diseases for more of the storage iron to be present as haemosiderin than normally, the most important factor affecting the distribution of iron between ferritin and haemosiderin was the total storage iron concentration. With total storage iron less than 500 mug. per gram of tissue, more iron was stored as ferritin than haemosiderin, and with values above 1,000 mug. per gram more was stored as haemosiderin. The behaviour of storage iron in this respect was very similar both in the liver and in the spleen. Although the histological and chemical estimates of the storage iron showed a general agreement there was much variation and histological examination of the tissues gave only a very approximate idea of the storage iron levels.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
Morgan EH,Walters MNdoi
10.1136/jcp.16.2.101subject
Has Abstractpub_date
1963-03-01 00:00:00pages
101-7issue
2eissn
0021-9746issn
1472-4146journal_volume
16pub_type
杂志文章abstract:BACKGROUND:Helicobacter pylori associated gastric cancer arises via a multistage process, with atrophic gastritis being the precursor lesion. Helicobacter pylori is typically acquired in childhood, yet little is known of the prevalence of atrophic gastritis in childhood. AIM:To study atrophic gastritis among children ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,多中心研究
doi:10.1136/jcp.2005.026310
更新日期:2005-11-01 00:00:00
abstract::Pathological findings are described in four cases of a new aminoaciduria in which homocystine is excreted in the urine. All the patients were mentally retarded children. Three of them presented diagnostic features of Marfan's syndrome. Necropsy on one case and biopsy findings in the others are described. Fatty change ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.17.4.427
更新日期:1964-07-01 00:00:00
abstract::A chemical method for the sterilization of pancreatin and trypsin is given. Evidence is presented to show that this treatment does not diminish the specific activity of the enzymes and has some advantages in microbiological techniques. ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.24.7.658
更新日期:1971-10-01 00:00:00
abstract::It has been suggested that Coxsackie B virus infections may play a part in causing or triggering myocardial infarction. This study was designed to compare the incidence of such infections in Coronary Care Unit patients and normal controls. The choice of a suitable criterion for diagnosis of Coxsackie infection is disc...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.36.6.658
更新日期:1983-06-01 00:00:00
abstract::The PAS and acid phosphatase reactions showed a different pattern of positivity in the cells of lymphoproliferative disorders according to their B or T cell nature. In B-cell leukaemias (chronic lymphocytic and prolymphocytic) a low proportion of lymphocytes gave a positive result with the acid phosphatase reaction, w...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.27.10.767
更新日期:1974-10-01 00:00:00
abstract:BACKGROUND:The Glasgow Prognostic Score (GPS), an inflammation-based prognostic score formed from standard thresholds of C reactive protein (CRP) and albumin, has prognostic value in patients with advanced cancer. Little is known about the general biochemical disturbance associated with the systemic inflammatory respon...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,多中心研究
doi:10.1136/jcp.2005.033217
更新日期:2007-06-01 00:00:00
abstract::A "Centrifichem" centrifugal analyser was found using a double fluorescence/bacterial tracer method to be a source of airborne and surface contamination in the laboratory. The airborne contamination was controlled by a modification incorporating a filter. Ubiquitous surface contamination generally accompanied the proc...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.41.11.1229
更新日期:1988-11-01 00:00:00
abstract::In this necropsy review of 37 cases of acute pancreatitis, evidence is presented that there are at least two different initiating mechanisms in acute necrotising pancreatitis in man. Firstly, there is primary duct inflammation, with subsequent inflammation and necrosis of the pancreatic parenchyma surrounding the excr...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.33.12.1125
更新日期:1980-12-01 00:00:00
abstract::The presence of serum agglutinins and precipitins to Candida albicans in men and women who had impaired bladder function following spinal injury is compared with that in other patients in hospital and in apparently fit men and women. Antibody levels which have commonly been regarded as significant were found in 35 of ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.27.9.722
更新日期:1974-09-01 00:00:00
abstract:AIMS:To investigate the correlation between centrally assessed human epidermal growth factor receptor 2 (HER2) immunohistochemistry (IHC) and fluorescence in situ hybridisation (FISH) results and response to treatment of patients with metastatic breast cancer enrolled in a first-line, phase II, open-label, 3-weekly tra...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2006.043562
更新日期:2008-01-01 00:00:00
abstract::Bone marrow infiltrates taken from 11 patients with peripheral T cell lymphoma were immunophenotyped as T cell lymphoma using monoclonal antibodies on frozen bone marrow trephine biopsy specimens. In nine these were taken at diagnosis and in two after failure of treatment to eradicate lymphoma in the marrow. Patterns ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.42.4.403
更新日期:1989-04-01 00:00:00
abstract::Endocardial fibroelastosis, defined as an endocardium in excess of 30 microns thick, was found in 10 out of 34 cases of hydrops fetalis in a review of 1589 perinatal necropsies carried out between 1976 and 1989. The infants comprised 16 cases of rhesus haemolytic disease, of whom three had endocardial fibroelastosis, ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.44.7.576
更新日期:1991-07-01 00:00:00
abstract::An automated method for the microbiological assay of vitamin B(12) is described. A chloramphenicol-resistant strain of Lactobacillus leichmannii is used as the test organism and this eliminates the need for sterilization or aseptic addition. Precipitation of the serum protein is avoided by dilution of the serum with a...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.26.7.494
更新日期:1973-07-01 00:00:00
abstract::A recently developed procedure, that has been shown to be suitable for detailed immunohistological analysis, has been used to prepare cryostat sections of bone marrow to investigate whether enzyme-histochemical techniques are also feasible on such material. A selected group of enzymes, some of which are inhibited or d...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.35.11.1220
更新日期:1982-11-01 00:00:00
abstract::Pseudolipoma of the liver is a rare condition which may be confused with metastatic tumours, primary tumours, or other lesions of the liver. This study presents three hepatic pseudolipomas that occurred in men aged 33, 38, and 42 years. The prevalence of hepatic pseudolipomas was 0.2% in a series of 1300 consecutive n...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.38.8.877
更新日期:1985-08-01 00:00:00
abstract::A small epidemic of gastroenteritis in a children's hospital is described, and also the biochemical characteristics of the causative organism. Stress is laid on the fact that failure to recognize that epidemic strains of Escherichia coli may be late lactose fermentors can lead to errors or delay in diagnosis. ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.15.5.482
更新日期:1962-09-01 00:00:00
abstract::The association between asymptomatic primary sclerosing cholangitis and exocrine pancreatic disease was underlined by the findings in a patient with cystic fibrosis and in another with chronic pancreatitis. In each case hepatocytes showed extensive microvesicular steatosis and studies of drug metabolism suggested hepa...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.42.5.466
更新日期:1989-05-01 00:00:00
abstract:AIMS:Lung cancer predictive biomarker testing is essential to select advanced-stage patients for targeted treatments and should be carried out without delays even during health emergencies, such as the coronavirus (COVID-19) outbreak. METHODS:Fifteen molecular laboratories from seven different European countries compa...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2020-206957
更新日期:2020-07-31 00:00:00
abstract::Liver copper concentrations in percutaneous biopsy specimens were measured by neutron activation analysis and compared with histological staining for copper by rubeanic acid and rhodanine, and with copper-associated protein stained by orcein. Liver copper concentrations were elevated in 31 of 35 biopsies from patients...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.31.8.784
更新日期:1978-08-01 00:00:00
abstract::In a post-mortem analysis of 1,500 patients, aged 70 years or more, heart disease and malignancy were the two major causes of death. Coronary disease was exceedingly prevalent, almost one in five being subject to this form of heart disease, and 13% dying from its effects. The levelling of the sex ratio in coronary dis...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.16.6.532
更新日期:1963-11-01 00:00:00
abstract:AIMS:The IHC4+C score combines assessment of oestrogen receptor (ER), progesterone receptor (PgR), HER2 and Ki67 with clinicopathological parameters to identify the risk of distant disease recurrence in patients with breast cancer, so, aiding treatment decision-making on adjuvant chemotherapy. Despite low cost and wide...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,多中心研究
doi:10.1136/jclinpath-2015-203212
更新日期:2016-02-01 00:00:00
abstract:AIMS:To evaluate the Questor automated bacteriuria and pyuria screening system; to compare its performance with that of a reference method; and to assess its usefulness in a routine clinical laboratory. METHODS:The Questor urine screening system was compared with a comprehensive regimen to detect urinary tract infecti...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.46.9.817
更新日期:1993-09-01 00:00:00
abstract::Two cases of chronic coronary periarteritis associated with chronic periaortitis are described. In one, the chronic periaortitis took the form of perianeurysmal fibrosis around a thoracic atherosclerotic aneurysm; in the other it resembled idiopathic retroperitoneal fibrosis. The findings in the two subjects support t...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.37.1.32
更新日期:1984-01-01 00:00:00
abstract::Activation of the complement system, the main humoral mediator of inflammation, is restrained by the action of enzyme inhibitors including alpha 1-antitrypsin. Deficiency leads to chronic liver disease in about one in five children with this genetic defect. Complement activation was investigated in 34 children with al...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.44.10.855
更新日期:1991-10-01 00:00:00
abstract::The ultrastructure of the osteocytes, osteoblasts, osteoclasts, haemopoietic and other connective tissue cells was examined in 27 biopsies from 22 patients with Paget's disease of bone. Electron microscopy showed characteristic nuclear and cytoplasmic inclusions in the osteoclasts of all of the 25 biopsies exhibiting ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.35.7.771
更新日期:1982-07-01 00:00:00
abstract::Two types of lymphocyte tubular structures were studied by electron microscopy in 80 patients with classic or definite rheumatoid arthritis (RA). Fifteen patients with unequivocal systemic lupus erythematosus (SLE) and 10 healthy persons were studied as controls. Lymphocyte tubulo-reticular structures were found in 13...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.30.9.822
更新日期:1977-09-01 00:00:00
abstract::Liver function was assessed in 38 Edinburgh haemophiliacs. Results before the introduction of NHS intermediate factor VIII concentrate from 1974 onwards were compared with values in 1979. Measurements of serum bile salts in 16 patients as well as conventional liver function tests gave useful evidence of deranged liver...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.34.1.17
更新日期:1981-01-01 00:00:00
abstract::These guidelines update the previous UK HER2 testing guidelines and have been formulated to give advice on methodology, interpretation and quality assurance to ensure that HER2 testing results are accurate, reliable and timely with the expansion of testing to all patients with breast cancer at the time of primary diag...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jcp.2007.054866
更新日期:2008-07-01 00:00:00
abstract::The placenta is the fetal organ providing the interchange between mother and fetus. This organ needs to provide its function such as transport and secretion even during its development and thus all developmental changes need to be in accordance with its function. This review describes development of the placenta durin...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jcp.2008.055277
更新日期:2008-12-01 00:00:00
abstract::One hundred cases of transitional cell carcinoma of the bladder were studied to determine whether squamous metaplasia and other histological features within the bladder can be of value in predicting outcome of treatment with radiotherapy. Sixty cases showed the changes of squamous metaplasia, and of this group 46 (78%...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.42.3.250
更新日期:1989-03-01 00:00:00