Impact of lymph node micrometastasis in hilar bile duct carcinoma patients.

Abstract:

AIM:To immunohistochemically examine micrometastasis and VEGF-C expression in hilar bile duct carcinoma (HBDC) and to evaluate the clinical significance of the results. METHODS:A total of 361 regional lymph nodes from 25 patients with node-negative HBDC were immunostained with an antibody against cytokeratins 8 and 18 (CAM 5.2), and immunohistochemical staining of VEGF-C was performed in 34 primary resected tumors. RESULTS:Lymph node micrometastasis was detected in 6 (24%) of the 25 patients and 10 (2.8%) of the 361 lymph nodes. Patients with micrometastasis showed significantly poorer survival rates than those without (P = 0.025). VEGF-C expression was positive in 17 (50%) of 34 HBDC, and significantly correlated with lymph node metastasis (P = 0.042) and microscopic venous invasion (P = 0.035). CONCLUSIONS:It is suggested that immunohistochemically detected lymph node micrometastasis has an impact on the outcome of HBDC. VEGF-C expression is highly correlated with lymph node metastasis in HBDC and might therefore be a useful predictor.

journal_name

World J Gastroenterol

authors

Taniguchi K,Iida T,Hori T,Yagi S,Imai H,Shiraishi T,Uemoto S

doi

10.3748/wjg.v12.i16.2549

subject

Has Abstract

pub_date

2006-04-28 00:00:00

pages

2549-55

issue

16

eissn

1007-9327

issn

2219-2840

journal_volume

12

pub_type

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