Abstract：
OBJECTIVES:The main objective of the research is an application of the clustering and cluster validity methods to estimate the number of clusters in cancer tumor datasets. A weighed voting technique is going to be used to improve the prediction of the number of clusters based on different data mining techniques. These tools may be used for the identification of new tumour classes using DNA microarray datasets. This estimation approach may perform a useful tool to support biological and biomedical knowledge discovery. METHODS:Three clustering and two validation algorithms were applied to two cancer tumor datasets. Recent studies confirm that there is no universal pattern recognition and clustering model to predict molecular profiles across different datasets. Thus, it is useful not to rely on one single clustering or validation method, but to apply a variety of approaches. Therefore, combination of these methods may be successfully used for the estimation of the number of clusters. RESULTS:The methods implemented in this research may contribute to the validation of clustering results and the estimation of the number of clusters. The results show that this estimation approach may represent an effective tool to support biomedical knowledge discovery and healthcare applications. CONCLUSION:The methods implemented in this research may be successfully used for the estimation of the number of clusters. The methods implemented in this research may contribute to the validation of clustering results and the estimation of the number of clusters. These tools may be used for the identification of new tumour classes using gene expression profiles.
journal_name
Methods Inf Medjournal_title
Methods of information in medicineauthors
Bolshakova N,Azuaje Fkeywords:
subject
Has Abstractpub_date
2006-01-01 00:00:00pages
153-7issue
2eissn
0026-1270issn
2511-705Xpii
06020153journal_volume
45pub_type
杂志文章abstract：OBJECTIVE:To draw a parallel between the challenges by which a research department in biomedical informatics is confronted and those of a symphony orchestra; in both areas different disciplines and various groups of instruments can be discerned. METHOD:Retrospective, personal review of how to conduct biomedical resear...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:A few years ago, a new method of survival analysis, denoted period analysis, has been developed to derive more up-to-date estimates of long-term survival rates of cancer patients, but this method has rarely been applied so far. Using empirical examples from the Saarland Cancer Registry, we illustrate how seriously tra...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2001-07-01 00:00:00
abstract：BACKGROUND:Interim analyses are used in clinical trials in order to enable early decisions for medical, ethical, and economic reasons. However, it appears unfeasible to stop a trial during such an interim analysis. New patients will thus enter the trial while the interim analysis is ongoing. Moreover, depending on the ...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME14-02-0023
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVES:This paper describes a methodology for the monitoring of the fetal cardiac health status during pregnancy, through the effective and non-invasive monitoring of the abdominal ECG signals (abdECG) of the mother. METHODS:For this purpose, a three-stage methodology has been developed. In the first stage, the fe...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME09-01-0041
更新日期：2010-01-01 00:00:00
abstract：OBJECTIVE:To evaluate the effectiveness of a lexico-syntactic pattern (LSP) matching method for ontology enrichment using clinical documents. METHODS:Two domains were separately studied using the same methodology. We used radiology documents to enrich RadLex and pathology documents to enrich National Cancer Institute ...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME10-01-0020
更新日期：2011-01-01 00:00:00
abstract：INTRODUCTION:This article is part of the Focus Theme of Methods of Information in Medicine on "Big Data and Analytics in Healthcare". BACKGROUND:Hospital readmissions raise healthcare costs and cause significant distress to providers and patients. It is, therefore, of great interest to healthcare organizations to pred...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME14-02-0017
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVES:The huge amount of released medical apps prevents medical app users from believing that medical scientific societies and other accreditation bodies as well, have the resources and the power for assigning to any medical app a quality score. By the time being, any medical app user has to take the risks related...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME13-01-0093
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVE:Pulmonary disorders are frequently characterized by the presence of adventitious sounds added to the breathing or base lung sound (BLS). The aim of this work was to assess the features of BLS in extrinsic allergic alveolitis (EAA) patients in comparison to healthy subjects, applying linear and nonlinear analy...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME12-01-0037
更新日期：2013-01-01 00:00:00
abstract：OBJECTIVE:The aim of this paper is twofold. First, we describe two important dimensions of patient care information systems (PCIS) evaluation: the domain of evaluation and the different phases of the PCIS implementation. Second, we claim that, though Randomized Controlled Trials (RCTs) are often still seen as the stand...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：OBJECTIVES:Rule induction is one of the major methods of machine learning. Rule-based models can be easily read and interpreted by humans, that makes them particularly useful in survival studies as they can help clinicians to better understand analysed data and make informed decisions about patient treatment. Although ...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME13-01-0046
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:The UMLS assigns semantic types to all its integrated concepts. The semantic types are widely used in various natural language processing tasks in the biomedical domain, such as named entity recognition, semantic disambiguation, and semantic annotation. Due to the size of the UMLS, erroneous semantic type as...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME17-01-0120
更新日期：2018-02-01 00:00:00
abstract：OBJECTIVE:The objective of this study is to develop a solution to preserve security and privacy in a healthcare environment where health-sensitive information will be accessed by many parties and stored in various distributed databases. The solution should maintain anonymous medical records and it should be able to lin...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/me9116
更新日期：2008-01-01 00:00:00
abstract：OBJECTIVES:Today's socio-economic developments in the healthcare area require continued optimization of processes and cost structures at hospitals, often associated with process changes for different occupational groups in the hospital. Formal methods for managing change have been established in other industries. The g...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME9235
更新日期：2009-01-01 00:00:00
abstract：:A rough-sets approach was applied to a data set consisting of animal study results and other compound characteristics to generate local and global (certain/possible) sets of rules for prediction of developmental toxicity in human subjects. A modified version of the rough-sets approach is proposed to allow the construc...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1993-02-01 00:00:00
abstract：OBJECTIVES:Describe how the HL7 Clinical Document Architecture (CDA), a foundational standard in US Meaningful Use, contributes to a "big data, incrementally structured" interoperability strategy, whereby data structured incrementally gets large amounts of data flowing faster. We present cases showing how this approach...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME14-01-0030
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVES:Complex physiological systems, such as the cardiovascular system, controlled by the autonomic nervous system, and the gait and posture system, controlled by the sensomotor nervous system, incorporate several controllers acting at different time scales. We investigated the question, whether the information fl...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：OBJECTIVES:This paper addresses the design of a platform for the management of medical decision data in the ICU. Whenever new medical data from laboratories or monitors is available or at fixed times, the appropriate medical support services are activated and generate a medical alert or suggestion to the bedside termin...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/me0480
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:Physical rehabilitation exergames (PREGs) are suitable for motivating patients toward completing treatments. Leap Motion (LM) is a motion sensor that may be useful for developing PREGs targeted at hands and fingers rehabilitation. Therefore, knowing the advantages and limitations of LM is relevant to underst...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.1055/s-0040-1715127
更新日期：2020-05-01 00:00:00
abstract：:A one-hundred percent documentation rate of diagnoses and patient data is unfeasible and should not be pursued. Therefore, a "lean documentation" of diagnoses and basic patient data was introduced. Coding is done by a clinic-specific list of diagnoses (thesaurus) with a minimum of diagnostic codes, combined with optio...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1997-08-01 00:00:00
abstract：:A problem of identifying the phase response curve of the myocardial pacemaker was investigated using a simple dynamic system model of cardiac arrhythmia. A hybrid optimization method of a genetic algorithm and a local optimization technique was employed to obtain a solution of the model fitting. The method was applied...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1997-12-01 00:00:00
abstract：OBJECTIVE:Joint data analysis is a key requirement in medical research networks. Data are available in heterogeneous formats at each network partner and their harmonization is often rather complex. The objective of our paper is to provide a generic approach for the harmonization process in research networks. We applied...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME14-02-0030
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVES:The analysis of energetic ventricular variable changes during artificial ventilation, obtained by numerical simulation was done. Twenty-one sets of hemodynamic parameters for eight cardiosurgical patients were used to estimate left and right stroke work. The data were collected for three methods of ventilati...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:The relationship was studied between the increase in oxygen uptake (VO2) measured breath-by-breath at the mouth, and the increase in femoral artery blood flow measured continuously with pulsed and echo Doppler methods. Five men exercised at 50 W on a knee extension ergometer in both the supine and the upright posture....
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1997-12-01 00:00:00
abstract：OBJECTIVES:A low rate of newly developed pressure ulcers is considered as an important quality indicator in nursing. However, the result of a hospital depends not only on the quality of care but on the risk profile of its patients as well. Therefore, based on multiple logistic regression models we describe a method for...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME10-01-0019
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:Each year, the International Medical Informatics Association Yearbook recognizes significant scientific papers, labelled as "best papers", published the previous year in the subfields of biomedical informatics that correspond to the different section topics of the journal. For each section, about fifteen pre...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME14-01-0031
更新日期：2015-01-01 00:00:00
abstract：:Artificial neural networks (ANNs) are compared to standard statistical methods for outcome prediction in biomedical problems. A general method for using genetic algorithms to "evolve" ANN architecture (EANN) is presented. Accuracy of logistic regression, a fully interconnected ANN, and an EANN for predicting depressio...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1998-09-01 00:00:00
abstract：BACKGROUND:For the statistical analysis of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data, compartment models are a commonly used tool. By these models, the observed uptake of contrast agent in some tissue over time is linked to physiologic properties like capillary permeability and blood flow. Up ...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME14-01-0131
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVE:To discuss the consequences for medical informatics in encouraging and advancing the development of information processing methodology (IPM) and information and communication technology (ICT) to contribute to high-quality and efficient health care. METHODS:Characterization of the current state of ICT, commen...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：OBJECTIVES:This study aimed at gaining comprehensive information on the current status of patient care and management applications used in German acute hospitals. Since the degree of ICT coverage in hospitals depends on the attitude of the key decision makers we also wanted to capture their plans and priorities and her...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:Surgical fluid replacement is a critical issue in medicine as the fluid volume excess or deficit can both complicate the patient's condition. Currently, the administration of fluid volume is carried out primarily based on the experience and expertise of the anaesthetist as there is no analytical method available to es...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2001-03-01 00:00:00
