Abstract：
OBJECTIVES:Complex physiological systems, such as the cardiovascular system, controlled by the autonomic nervous system, and the gait and posture system, controlled by the sensomotor nervous system, incorporate several controllers acting at different time scales. We investigated the question, whether the information flow as a function of prediction time enables the identification of those contributing controllers within the entire complex system behavior. METHODS:Information flow functions assess the predictability of a time series. They were calculated based on mutual information over prediction time horizon tau. The importance of considering appropriate time scales tau was introduced by a simulation study of an excited pendulum. Based on heart rate data, complex autonomic dysfunctions were assessed by using autonomic information flow (AIF) in an experimental study of rats and in clinical studies of patients with multiple organ dysfunction syndrome (MODS) and after cardiac arrest (CA). Motor dysfunction in elderly suffering from low back pain was assessed by gait information flow (GIF) based on back movements. RESULTS:In rats, AIF over one heart beat period was reduced due to anesthesia, AIF over vagal time scale was increased due to vagotomy. In both, MODS and CA patients, vagal time scale AIF was reduced, but longterm AIF was increased. In low back pain patients, short loop GIF was increased, but walking period-related GIF was reduced. CONCLUSIONS:Information flow functions allow the identification of particular controllers and their interdependencies within complex physiological systems.
journal_name
Methods Inf Medjournal_title
Methods of information in medicineauthors
Hoyer Dsubject
Has Abstractpub_date
2007-01-01 00:00:00pages
121-5issue
2eissn
0026-1270issn
2511-705Xpii
07020121journal_volume
46pub_type
杂志文章abstract：OBJECTIVES:Biomedical ontologies exist to serve integration of clinical and experimental data, and it is critical to their success that they be put to widespread use in the annotation of data. How, then, can ontologies achieve the sort of user-friendliness, reliability, cost-effectiveness, and breadth of coverage that ...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME9302
更新日期：2010-01-01 00:00:00
abstract：OBJECTIVES:Benchmarking statements provide a mechanism for making academic standards explicit within a subject area. They allow comparisons between courses to be based on learning outcomes rather than by defining a curriculum. No such statement has been produced for informatics. In the absence of any established benchm...
journal_title：Methods of information in medicine
pub_type： 杂志文章,评审
doi：10.1160/me0442
更新日期：2007-01-01 00:00:00
abstract：:Reliable record linkage is a prerequisite for high-quality population-based disease registration. Rapid developments in computer processing have made record linkage both more efficient and more reliable in recent years. At the same time, concerns about confidentiality increasingly hinder record linkage in many disease...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：OBJECTIVES:The National Cancer Institute (NCI) has developed the Common Data Elements (CDE) to serve as a controlled vocabulary of data descriptors for cancer research, to facilitate data interchange and inter-operability between cancer research centers. We evaluated CDE's structure to see whether it could represent th...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：OBJECTIVES:In this study, we evaluated the internal validity of EPICON, an application for grouping ICPC-coded diagnoses from electronic medical records into episodes of care. These episodes are used to estimate morbidity rates in general practice. METHODS:Morbidity rates based on EPICON were compared to a gold standa...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：INTRODUCTION:This article is part of the focus theme of Methods of Information in Medicine on "Pervasive Intelligent Technologies for Health". BACKGROUND:This paper addresses the evaluation with hospital staff of an in-patient environment that supports patients, family, nursing staff and medical specialists during the...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME13-02-0032
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:The International Classification of Functioning, Disability and Health (ICF) has been available as a means of coding life functions but the coding process is cumbersome due to the large number of ICF codes. In the current study, we developed ICF code selection tools to support the coding of activity and part...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME10-01-0062
更新日期：2011-01-01 00:00:00
abstract：:A Bonhoeffer-van der Pol equation with a stable limit cycle is proposed as a model of the pacemaker in the sino-atrial node to explain heart rate regulation. Standard tools, such as the phase transition curve in nonlinear dynamic system theory, are used to analyze the model and results are compared with other studies ...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
abstract：UNLABELLED:The HL7 Clinical Document Architecture (CDA) is an important XML-based standard for the representation of clinical documents. OBJECTIVES:The use of Markup Languages could satisfy the demands of involved healthcare staff as well as the needs of patients, to receive an overview of the patient's treatment duri...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:Three ways are proposed to help the occupational physician in constructing a worker's job history or Curriculum Laboris (CL) with a PC. The quality and, therefore, the usefulness of any job history is greatly conditioned by the method and quality of data collection. The Curriculum Laboris method explained in a previou...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1990-03-01 00:00:00
abstract：INTRODUCTION:This article is part of the Focus Theme of METHODs of Information in Medicine on "Managing Interoperability and Complexity in Health Systems". BACKGROUND:SALUS project aims at building an interoperability platform and a dedicated toolkit to enable secondary use of electronic health records (EHR) data for ...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME13-02-0025
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVES:Several researchers have proposed the use of logical ontologies as 'reference terminologies'. However, there are a number of unresolved issues. This article describes the development of a logical ontology for nursing interventions and presents the results of evaluation. METHODS:Initially this study involved...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：OBJECTIVES:The analysis of energetic ventricular variable changes during artificial ventilation, obtained by numerical simulation was done. Twenty-one sets of hemodynamic parameters for eight cardiosurgical patients were used to estimate left and right stroke work. The data were collected for three methods of ventilati...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:The PHOENIX Radiology Consultant is a rule-based expert system which assists physicians in planning radiological work-up strategies. This article describes the methods used to create and validate the system's knowledge base. The feasibility and acceptability of PHOENIX were tested for two years in a clinical trial. Du...
journal_title：Methods of information in medicine
pub_type： 临床试验,杂志文章
doi：
更新日期：1991-10-01 00:00:00
abstract：:A Template Definition Language (TDL) was developed to share knowledge of how to construct an electronic patient record (EPR) template. Based on the extensible markup language XML, TDL has been designed to be independent of EPR platforms or databases. Our research of TDL was conducted through evaluation of the descript...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2000-03-01 00:00:00
abstract：:Informatisation of drug prescription is an important topic in medical informatics. For several years now, computerized drug databases have been implemented. Usually only a small part of the prescriptions can be stored in prescription systems because of the format of the included information; prescriptions contain esse...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1999-03-01 00:00:00
abstract：:Human event-related potentials reflect cognitive processing, and are normally elicited by external events, such as acoustic sounds or visual stimuli. As such they provide an opportunity to study normal and abnormal brain function noninvasively, at sub-second resolution. Advances in multimedia technology permit special...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2001-07-01 00:00:00
abstract：BACKGROUND:Multi-class molecular cancer classification has great potential clinical implications. Such applications require statistical methods to accurately classify cancer types with a small subset of genes from thousands of genes in the data. OBJECTIVES:This paper presents a new functional gradient descent boosting...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME11-02-0020
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:The UMLS assigns semantic types to all its integrated concepts. The semantic types are widely used in various natural language processing tasks in the biomedical domain, such as named entity recognition, semantic disambiguation, and semantic annotation. Due to the size of the UMLS, erroneous semantic type as...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME17-01-0120
更新日期：2018-02-01 00:00:00
abstract：OBJECTIVES:A major problem associated with the irradiation of thoracic and abdominal tumors is respiratory motion. In clinical practice, motion compensation approaches are frequently steered by low-dimensional breathing signals (e.g., spirometry) and patient-specific correspondence models, which are used to estimate th...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME13-01-0137
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVES:The objective of this study was to explore suitable spatial filters for inverse estimation of cortical potentials from the scalp electroencephalogram. The effect of incorporating noise covariance into inverse procedures was examined by computer simulations and tested in human experiment. METHODS:The paramet...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:Main requirements for an Anesthesia Information Management System (AIMS) are the supply of additional information for the anesthesiologist at his workstation and complete documentation of the anesthetic procedure. With the implementation of an AIMS (NarkoData) and effective user support, the quality of documentation a...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2000-12-01 00:00:00
abstract：OBJECTIVES:In the field of open electronic health records (EHRs), openEHR as an archetype-based approach is being increasingly recognised. It is the objective of this paper to shortly describe this approach, and to analyse how openEHR archetypes impact on health professionals and semantic interoperability. METHODS:Ana...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.1160/ME5001
更新日期：2007-01-01 00:00:00
abstract：OBJECTIVES:The main objective of the research is an application of the clustering and cluster validity methods to estimate the number of clusters in cancer tumor datasets. A weighed voting technique is going to be used to improve the prediction of the number of clusters based on different data mining techniques. These ...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:The availability of large amounts of data in heterogeneous formats and the rapid progress in fields such as computer based drug design, medical imaging and medical simulations have lead to a growing demand for large computational power and easy accessibility to heterogeneous data sources. OBJECTIVES:The goa...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:The illustration of a patient's history by a graphical primitive is discussed. Illustration technology is presented which simultaneously represents quantitative examination findings (e.g., laboratory values) and qualitative findings (e.g., from function diagnostics) by a single geometrical figure. Depending on the med...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1995-06-01 00:00:00
abstract：:The use of computers in the health sector has increased significantly during the last few years in Nigeria. This paper addresses the integration of health and informatics education, or health education and informatics education, or informatics education in health care delivery. It gives an introduction to the status o...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：1997-02-01 00:00:00
abstract：BACKGROUND:This article describes the development and evaluation of a distributed user interface (DUI) application to assess visuomotor organization ability. This application enables therapists to evaluate the acquired brain injury (ABI) on patients, and patients, to perform the assessment on a touch screen while thera...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.1055/s-0040-1713086
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:The information present in Hospital Information Systems (HIS) is heterogeneous and is used primarily by health practitioners to support and improve patient care. Conducting clinical research, data analyses or knowledge discovery projects using electronic patient data in secondary care centres relies on accur...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：10.3414/ME10-01-0069
更新日期：2012-01-01 00:00:00
abstract：OBJECTIVE:The aim of this paper is twofold. First, we describe two important dimensions of patient care information systems (PCIS) evaluation: the domain of evaluation and the different phases of the PCIS implementation. Second, we claim that, though Randomized Controlled Trials (RCTs) are often still seen as the stand...
journal_title：Methods of information in medicine
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
