Abstract:
:Electrospinning is a versatile process used to prepare micro- and nano- sized fibers from various polymers dissolved in volatile solvents. In this report, cellulose and cellulose-heparin composite fibers are prepared from nonvolatile room temperature ionic liquid (RTIL) solvents by electrospinning. RTILs are extracted from the biopolymer fiber after the fiber formation using a cosolvent. Micron to nanometer sized, branched fibers were obtained from 10% (w/w) concentration of polysaccharide biopolymer in RTIL solution with an applied voltage of 15-20 kV. Cellulose-heparin composite fibers showed anticoagulant activity, demonstrating that the bioactivity of heparin remained unaffected even on exposure to a high voltage involved in electrospinning.
journal_name
Biomacromoleculesjournal_title
Biomacromoleculesauthors
Viswanathan G,Murugesan S,Pushparaj V,Nalamasu O,Ajayan PM,Linhardt RJdoi
10.1021/bm050837skeywords:
subject
Has Abstractpub_date
2006-02-01 00:00:00pages
415-8issue
2eissn
1525-7797issn
1526-4602journal_volume
7pub_type
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