Abstract:
:We describe an efficient, accurate and robust whole-genome genotyping (WGG) assay based on a two-color, single-base extension (SBE), single-nucleotide polymorphism (SNP)-scoring step. We report genotyping results for biallelic International HapMap quality control (QC) SNPs using a single probe per locus. We show scalability, throughput and accuracy of the system by resequencing homozygous loci from our 100k Human-1 Genotyping BeadChip.
journal_name
Nat Methodsjournal_title
Nature methodsauthors
Steemers FJ,Chang W,Lee G,Barker DL,Shen R,Gunderson KLdoi
10.1038/nmeth842keywords:
subject
Has Abstractpub_date
2006-01-01 00:00:00pages
31-3issue
1eissn
1548-7091issn
1548-7105pii
nmeth842journal_volume
3pub_type
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