Abstract：
OBJECTIVES:To determine demographic or disease-related factors that may influence the severity of autonomic dysfunction in idiopathic Parkinson's disease (IPD). METHODS:532 patients with IPD aged between 55 and 75 years were included. Severity of autonomic dysfunction was assessed using a 9-item autonomic dysfunction score (ADS). In addition, several demographic factors (e. g. age, gender, comorbidities) and disease- related (e. g. motor stage, disease duration, antiparkinsonian therapy) factors were recorded. A group of 67 age-matched healthy volunteers served as a control group. Demographic and clinical data of this cross-sectional survey were analyzed by a logistic stepwise regression model to determine independent predictors of autonomic dysfunction. RESULTS:IPD patients showed significantly higher ADS values than controls, even in the youngest age groups and in mild disease stages. Hoehn & Yahr (H&Y) stage, disease duration, age at onset and various therapy combinations all showed significant correlations with ADS. However, stepwise logistic regression revealed that age (OR 10.71; CI 7.17-16.0) and arterial hypertension (OR 3.05; CI 1.66-5.58) were the only independent risk factors associated with autonomic dysfunction. Linear regression indicated that ADS increases with age in controls as well as in patients, but with a significantly steeper slope in the latter. CONCLUSIONS:Autonomic dysfunction as an inherent feature of IPD is present already in early disease stages. According to a logistic regression model, the severity of autonomic dysfunction in IPD is primarily related to demographic but not to disease-related factors. This and the differences in predictors for motor versus autonomic decline may indicate at least partly independent neurodegenerative processes.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Korchounov A,Kessler KR,Yakhno NN,Damulin IV,Schipper HIdoi
10.1007/s00415-005-0909-6keywords:
subject
Has Abstractpub_date
2005-12-01 00:00:00pages
1530-6issue
12eissn
0340-5354issn
1432-1459journal_volume
252pub_type
杂志文章,多中心研究abstract：:Although silent infarcts (SIs) are frequent in stroke patients, their clinical significance remains controversial, and their effect on stroke outcome remains unclear. This study evaluated the prevalence of SI on computed tomography, associated factors, and the effect on outcome in stroke patients. We studied 202 conse...
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pub_type： 杂志文章,评审
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更新日期：2002-08-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章,评审
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更新日期：2009-11-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1007/s00415-020-10223-9
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