Extending the time window for thrombolysis: evidence from acute stroke trials.

Abstract:

:Data from intravenous tissue plasminogen activator studies have shown rapidly diminishing clinical benefit beyond 3 hours when noncontrast CT is used for treatment triage. Newer trials, such as the Desmoteplase in Acute Ischemic Stroke trial, have now successfully pushed the time window out to 9 hours using the concept of penumbral imaging and treatment of the perfusion-diffusion mismatch. Advanced imaging with CT or MR imaging protocols is providing a means for rational physiologic selection and outcomes assessment in stroke treatment.

journal_name

Neuroimaging Clin N Am

authors

Rowley HA

doi

10.1016/j.nic.2005.08.002

keywords:

subject

Has Abstract

pub_date

2005-08-01 00:00:00

pages

575-87, x

issue

3

eissn

1052-5149

issn

1557-9867

pii

S1052-5149(05)00052-3

journal_volume

15

pub_type

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