Regio-selective 10-hydroxylation of patchoulol, a sesquiterpene, by pithomyces species.

Abstract:

:Of some 350 microorganisms screened, four strains of Pithomyces species were found to carry out regio-selective hydroxylation of patchoulol, a sesquiterpene, to 10-hydroxypatchoulol: Pithomyces sp. NRJ201, P. chartarum NRJ210, and, to a lesser extent, P. cynodontis ATCC 26150 and P. atro-olivaceus IFO 6651 were found to catalyze this reaction. A method has been developed by which 10-hydroxypatchoulol was obtained in 25 to 45% yields in 1- to 5-liter fermentation jars at 2 to 4 g of patchoulol per liter and isolated as pure material in 30% yields.

journal_name

Appl Environ Microbiol

authors

Suhara Y,Itoh S,Ogawa M,Yokose K,Sawada T,Sano T,Ninomiya R,Maruyama HB

doi

10.1128/AEM.42.2.187-191.1981

keywords:

subject

Has Abstract

pub_date

1981-08-01 00:00:00

pages

187-91

issue

2

eissn

0099-2240

issn

1098-5336

journal_volume

42

pub_type

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