Transfer of very low density lipoprotein-associated phospholipids to activated human platelets.

abstract：:Neutral sphingomyelinase-2 (nSMase2) is a key ceramide-producing enzyme in cellular stress responses. While many posttranslational regulators of nSMase2 are known, emerging evidence suggests a more protracted regulation of nSMase2 at the transcriptional level. Previously, we reported that nSMase2 is induced by all-tra...

journal_title：Journal of lipid research

authors： Clarke CJ,Shamseddine AA,Jacob JJ,Khalife G,Burns TA,Hannun YA

更新日期：2016-05-01 00:00:00

abstract：:The properties of cholesteryl oleate and triolein in mixed monolayers at the air-water interface have been measured between 24 and 37 degrees C. Analysis of force-area curves obtained as a function of the mol fraction of cholesteryl oleate indicates that at relatively low surface pressures these compounds are miscible...

journal_title：Journal of lipid research

authors： Smaby JM,Brockman HL

更新日期：1978-03-01 00:00:00

abstract：:LPL is an enzyme involved in the breakdown and uptake of lipoprotein triglycerides. In the present study, we examined how the transgenic (Tg) overexpression of human LPL in mouse skeletal muscle affected tolerance to cold temperatures, cold-induced thermogenesis, and fuel utilization during this response. Tg mice and ...

journal_title：Journal of lipid research

authors： Jensen DR,Knaub LA,Konhilas JP,Leinwand LA,MacLean PS,Eckel RH

更新日期：2008-04-01 00:00:00

abstract：:ABCA12 mutations disrupt the skin barrier and cause harlequin ichthyosis. We previously showed Abca12(-/-) skin has increased glucosylceramide (GlcCer) and correspondingly lower amounts of ceramide (Cer). To examine why loss of ABCA12 leads to accumulation of GlcCer, de novo sphingolipid synthesis was assayed using [(...

journal_title：Journal of lipid research

authors： Haller JF,Cavallaro P,Hernandez NJ,Dolat L,Soscia SJ,Welti R,Grabowski GA,Fitzgerald ML,Freeman MW

更新日期：2014-03-01 00:00:00

abstract：:A device for the simultaneous evaporation of six samples under separately controlled streams of nitrogen is described. ...

journal_title：Journal of lipid research

authors： Komarek RJ

更新日期：1967-05-01 00:00:00

abstract：:Cyclophosphamide injection into the fasted rabbit induces a hypertriglyceridemia (4.6 mM vs. 0.8 mM in controls) and a defect of lipoprotein lipase (LPL), as measured in post-heparin plasma (PHP). In contrast, administration of the drug into fed animals tends to increase PHP-LPL. The effects of cyclophosphamide on LPL...

journal_title：Journal of lipid research

authors： Lespine A,Azema C,Gafvels M,Manent J,Dousset N,Chap H,Perret B

更新日期：1993-01-01 00:00:00

abstract：:The dynamics of human apoE metabolism were explored by examining the effects of alimentary lipemia and postheparin lipolysis on the plasma level and lipoprotein distribution of apoE. In the studies of alimentary lipemia, fasting and postprandial plasma samples were obtained from five normal adult males, each of whom d...

journal_title：Journal of lipid research

authors： Blum CB

更新日期：1982-12-01 00:00:00

abstract：:The vitamin D signal transduction system involves a series of cytochrome P450-containing sterol hydroxylases to generate and degrade the active hormone, 1α,25-dihydroxyvitamin D3, which serves as a ligand for the vitamin D receptor-mediated transcriptional gene expression described in companion articles in this review...

journal_title：Journal of lipid research

authors： Jones G,Prosser DE,Kaufmann M

更新日期：2014-01-01 00:00:00

abstract：:Serum amyloid A (SAA) is an acute phase reactant that can become the predominant apolipoprotein of high density lipoprotein (HDL) during severe inflammatory states. However, the function of SAA is unknown. To study the ability of SAA to form HDL in the absence of apolipoprotein A-I, we expressed the mouse SAA pI 6.15 ...

journal_title：Journal of lipid research

authors： Webb NR,de Beer MC,van der Westhuyzen DR,Kindy MS,Banka CL,Tsukamoto K,Rader DL,de Beer FC

更新日期：1997-08-01 00:00:00

abstract：:Glycosyl hydrolases (GHs) are carbohydrate-active enzymes that hydrolyze a specific β-glycosidic bond in glycoconjugate substrates; β-glucosidases degrade glucosylceramide, a ubiquitous glycosphingolipid. GHs are grouped into structurally similar families that themselves can be grouped into clans. GH1, GH5, and GH30 g...

journal_title：Journal of lipid research

authors： Ben Bdira F,Artola M,Overkleeft HS,Ubbink M,Aerts JMFG

更新日期：2018-12-01 00:00:00

abstract：:A modification of the semiautomated assay method of Antonis (1965. J. Lipid Res. 6:307-312) for free fatty acid is presented. Free fatty acids are extracted from serum or plasma into di-n-butyl ether-2-methoxyethanol; the extract is almost free from phospholipids. The acids are analyzed in a portion of extract by a co...

journal_title：Journal of lipid research

authors： Bowyer DE,Cridland JS,King JP

更新日期：1978-02-01 00:00:00

abstract：:After stereospecific oxidation, trimethylsilylated methyl esters of mono- and diunsaturated fatty acids were analyzed by combined gas-liquid chromatography-chemical ionization mass spectrometry. The positions of original double bonds were deduced from the fragment ions produced by the cleavage of the carbon-carbon bon...

journal_title：Journal of lipid research

authors： Murata T,Ariga T,Araki E

更新日期：1978-02-01 00:00:00

abstract：:Two assays for the quantitative measurement of HMG-CoA reductase, the major regulatory enzyme in hepatic cholesterol biosynthesis, are described. The first of these procedures employs thin-layer chromatography (TLC) of the reaction product on plastic-backed silica gel G strips impregnated with ammonium carbonate. The ...

journal_title：Journal of lipid research

authors： Ackerman ME,Redd WL,Tormanen CD,Hardgrave JE,Scallen TJ

更新日期：1977-05-01 00:00:00

abstract：:The hydrolysis of HDL phospholipids (PL) and glycerides by hepatic lipase (HL) has been investigated in native and reconstituted HDL particles (Lp2A-I). Fasting, normolipidemic HDL exhibit total lipid hydrolytic rates of between 10 and 36 nM FA/h per microM PL. Of the total fatty acids liberated with HDL3 only 1% are ...

journal_title：Journal of lipid research

authors： Coffill CR,Ramsamy TA,Hutt DM,Schultz JR,Sparks DL

更新日期：1997-11-01 00:00:00

abstract：:The effect of microbiological deconjugation of bile acids on total bile acid and neutral sterol fecal excretion by adult male rats has been studied. A screening method utilizing mice allowed selection of a Clostridium perfringens type A strain, which accelerated cholesterol catabolism in mice. When this species of bac...

journal_title：Journal of lipid research

authors： Kellogg TF,Knight PL,Wostmann BS

更新日期：1970-07-01 00:00:00

abstract：:Hepatocytes express on their surfaces more than one class of receptors capable of mediating the internalization of lipoproteins. However, relatively little is known about the binding characteristics of hepatic receptors for various lipoproteins, about the regulation of the receptors, and about the consequences for int...

journal_title：Journal of lipid research

authors： Tamai T,Patsch W,Lock D,Schonfeld G

更新日期：1983-12-01 00:00:00

abstract：:Our previous studies have demonstrated the activity of oncostatin M (OM) in stimulating the transcription of the human LDL receptor (LDLR) gene in HepG2 cells through a sterol-independent regulatory mechanism. The current studies were designed to determine whether this in vitro property of OM could be recapitulated in...

journal_title：Journal of lipid research

authors： Kong W,Abidi P,Kraemer FB,Jiang JD,Liu J

更新日期：2005-06-01 00:00:00

abstract：:In mice, the yolk sac appears to play a crucial role in nourishing the developing embryo, especially during embryonic days (E) 7;-10. Lipoprotein synthesis and secretion may be essential for this function: embryos lacking apolipoprotein (apo) B or microsomal triglyceride transfer protein (MTP), both of which participa...

journal_title：Journal of lipid research

authors： Terasawa Y,Cases SJ,Wong JS,Jamil H,Jothi S,Traber MG,Packer L,Gordon DA,Hamilton RL,Farese RV Jr

更新日期：1999-11-01 00:00:00

abstract：:Animal studies have suggested that angiopoietin-like 4 (Angptl4) regulates adiposity through central and peripheral mechanisms. The aim of this study was to investigate whether serum concentration and adipose tissue expression of Angptl4 are associated with obesity-related parameters in humans. Altogether, 75 dizygoti...

journal_title：Journal of lipid research

authors： Robciuc MR,Naukkarinen J,Ortega-Alonso A,Tyynismaa H,Raivio T,Rissanen A,Kaprio J,Ehnholm C,Jauhiainen M,Pietiläinen KH

更新日期：2011-08-01 00:00:00

abstract：:Long-chain polyunsaturated fatty acids (PUFA) orchestrate immunity and inflammation through their capacity to be converted to potent inflammatory mediators. We assessed associations of FADS gene cluster polymorphisms and fasting serum PUFA concentrations in a fully ascertained, geographically isolated founder populati...

journal_title：Journal of lipid research

authors： Mathias RA,Vergara C,Gao L,Rafaels N,Hand T,Campbell M,Bickel C,Ivester P,Sergeant S,Barnes KC,Chilton FH

更新日期：2010-09-01 00:00:00

abstract：:Adipocyte triglyceride storage provides a reservoir of energy that allows the organism to survive times of nutrient scarcity, but excessive adiposity has emerged as a health problem in many areas of the world. Monoacylglycerol acyltransferase (MGAT) acylates monoacylglycerol to produce diacylglycerol; the penultimate ...

journal_title：Journal of lipid research

authors： Liss KHH,Lutkewitte AJ,Pietka T,Finck BN,Franczyk M,Yoshino J,Klein S,Hall AM

更新日期：2018-09-01 00:00:00

abstract：:Spectrophotometric techniques for determining the activities of lipases, lysophospholipases, and phospholipases are reviewed. These methods involve the use of thioester substrate analogs as well as omega-nitrophenyl derivatives of the corresponding lipids. The most promising results are obtained with the thioester sub...

journal_title：Journal of lipid research

authors： Farooqui AA,Taylor WA,Pendley CE 2nd,Cox JW,Horrocks LA

更新日期：1984-12-15 00:00:00

abstract：:Apolipoprotein A-II (apoA-II) is the second major apolipoprotein following apolipoprotein A-I (apoA-I) in HDL. ApoA-II has multiple physiological functions and can form senile amyloid fibrils (AApoAII) in mice. Most circulating apoA-II is present in lipoprotein A-I/A-II. To study the influence of apoA-I on apoA-II and...

journal_title：Journal of lipid research

authors： Wang Y,Sawashita J,Qian J,Zhang B,Fu X,Tian G,Chen L,Mori M,Higuchi K

更新日期：2011-08-01 00:00:00

abstract：:Three mammalian cell lines were examined for their ability to metabolize the regulatory oxysterol, 25-hydroxycholesterol, and derepress 3-hydroxy-3-methylglutaryl CoA reductase. In mouse L cell fibroblasts reductase activity was restored with the concomitant metabolism of 25-hydroxycholesterol via side-chain hydroxyla...

journal_title：Journal of lipid research

authors： Taylor FR,Kandutsch AA

更新日期：1989-06-01 00:00:00

abstract：:Elongation of very long chain fatty acid-like family member 6 (ELOVL6) is a fatty acyl elongase that performs the initial and rate-limiting condensing reaction required for microsomal elongation of long-chain fatty acids. Our previous in vitro studies suggested that ELOVL6 elongated long-chain saturated fatty acids an...

journal_title：Journal of lipid research

authors： Moon YA,Ochoa CR,Mitsche MA,Hammer RE,Horton JD

更新日期：2014-12-01 00:00:00

abstract：:As microsomal triglyceride transfer protein (MTP) is required for the assembly and secretion of apoB-containing lipoproteins by intestinal epithelial cells, the characterization and regulation of MTP in human intestinal cells, CaCo-2, was studied. CaCo-2 cells express MTP mRNA of 4.2 kb and a 97 kDa subunit of MTP pro...

journal_title：Journal of lipid research

authors： Mathur SN,Born E,Murthy S,Field FJ

更新日期：1997-01-01 00:00:00

abstract：:Spontaneously transformed mouse fibroblasts (Balb/c 3T12-3 cells) displayed an increased adhesion when cultured in the presence of 10(-6) M all-trans retinol and acquired morphological characteristics of the normal phenotype. Thus it was of interest to investigate the metabolism of [15-(14)C]retinol in this system. Wi...

journal_title：Journal of lipid research

authors： Bhat PV,De Luca LM,Adamo S,Akalovsky I,Silverman-Jones CS,Peck GL

更新日期：1979-03-01 00:00:00

abstract：:Four hours after intraportal injection of retinoic acid-(14)C into bile duct-cannulated rats, less than 10% of the radioactivity was recovered in the liver, intestine, and kidneys. Within 6 hr, 40% of the radioactivity had appeared in bile. When suspensions of retinol-(14)C or retinal were similarly injected, 25-35% o...

journal_title：Journal of lipid research

authors： Zachman RD,Dunagin PE Jr,Olson JA

更新日期：1966-01-01 00:00:00

abstract：:Lilly PCSK9 antibody LY3015014 (LY) is a monoclonal antibody (mAb) that neutralizes proprotein convertase subtilisin-kexin type 9 (PCSK9). LY decreases LDL cholesterol in monkeys and, unlike other PCSK9 mAbs, does not cause an accumulation of intact PCSK9 in serum. Comparing the epitope of LY with other clinically tes...

journal_title：Journal of lipid research

authors： Schroeder KM,Beyer TP,Hansen RJ,Han B,Pickard RT,Wroblewski VJ,Kowala MC,Eacho PI

更新日期：2015-11-01 00:00:00

abstract：:The de novo ceramide synthesis pathway is essential to human biology and health, but genetic influences remain unexplored. The core function of this pathway is the generation of biologically active ceramide from its precursor, dihydroceramide. Dihydroceramides have diverse, often protective, biological roles; converse...

journal_title：Journal of lipid research

authors： Blackburn NB,Michael LF,Meikle PJ,Peralta JM,Mosior M,McAhren S,Bui HH,Bellinger MA,Giles C,Kumar S,Leandro AC,Almeida M,Weir JM,Mahaney MC,Dyer TD,Almasy L,VandeBerg JL,Williams-Blangero S,Glahn DC,Duggirala R,Ko

更新日期：2019-09-01 00:00:00