FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population.

Abstract:

:Long-chain polyunsaturated fatty acids (PUFA) orchestrate immunity and inflammation through their capacity to be converted to potent inflammatory mediators. We assessed associations of FADS gene cluster polymorphisms and fasting serum PUFA concentrations in a fully ascertained, geographically isolated founder population of European descent. Concentrations of 22 PUFAs were determined by gas chromatography, of which ten fatty acids and five ratios defining FADS1 and FADS2 activity were tested for genetic association against 16 single nucleotide polymorphisms (SNP) in 224 individuals. A cluster of SNPs in tight linkage disequilibrium in the FADS1 gene (rs174537, rs174545, rs174546, rs174553, rs174556, rs174561, rs174568, and rs99780) were strongly associated with arachidonic acid (AA) (P = 5.8 x 10(-7) - 1.7 x 10(-8)) among other PUFAs, but the strongest associations were with the ratio measuring FADS1 activity in the omega-6 series (P = 2.11 x 10(-13) - 1.8 x 10(-20)). The minor allele across all SNPs was consistently associated with decreased omega-6 PUFAs, with the exception of dihomo-gamma-linoleic acid (DHGLA), where the minor allele was consistently associated with increased levels. Our findings in a geographically isolated population with a homogenous dietary environment suggest that variants in the Delta-5 desaturase enzymatic step likely regulate the efficiency of conversion of medium-chain PUFAs to potentially inflammatory PUFAs, such as AA.

journal_name

J Lipid Res

authors

Mathias RA,Vergara C,Gao L,Rafaels N,Hand T,Campbell M,Bickel C,Ivester P,Sergeant S,Barnes KC,Chilton FH

doi

10.1194/jlr.M008359

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

2766-74

issue

9

eissn

0022-2275

issn

1539-7262

pii

jlr.M008359

journal_volume

51

pub_type

杂志文章
  • Ceramide and sphingomyelin species of fibroblasts and neurons in culture.

    abstract::The ceramide (Cer) and sphingomyelin (SM) species of cultured differentiated rat cerebellar granule cells and human fibroblasts were characterized by electrospray ionization-mass spectrometry. We identified 35 different species of Cer and 18 species of SM in human fibroblasts, and 35 different species of Cer and 9 spe...

    journal_title:Journal of lipid research

    pub_type: 杂志文章

    doi:10.1194/jlr.M600344-JLR200

    authors: Valsecchi M,Mauri L,Casellato R,Prioni S,Loberto N,Prinetti A,Chigorno V,Sonnino S

    更新日期:2007-02-01 00:00:00

  • Compensated endocytosis of LDL by hamster cells co-expressing the two distinct mutant LDL receptors defective in endocytosis and ligand binding.

    abstract::The low density lipoprotein receptor (LDLR) regulates the plasma cholesterol level by mediating endocytosis of LDL. We established stable hamster cell lines expressing two LDLRs with distinct functional defects, i.e., endocytosis and ligand binding. In the cell line expressing only I189D h/r (human-rat chimeric) LDLR,...

    journal_title:Journal of lipid research

    pub_type: 杂志文章

    doi:

    authors: Yoshida H,Yokode M,Yamamoto A,Masaki R,Murayama T,Horiuchi H,Kita T

    更新日期:1999-05-01 00:00:00

  • Adiponectin forms a complex with atherogenic LDL and inhibits its downstream effects.

    abstract::Adiponectin, an adipocyte-derived protein, has anti-atherogenic and anti-diabetic effects, but how it confers the anti-atherogenic effects is not well understood. To study the anti-atherogenic mechanisms of adiponectin, we examined whether it interacts with atherogenic low-density lipoprotein (LDL) to attenuate LDL's ...

    journal_title:Journal of lipid research

    pub_type: 杂志文章

    doi:10.1194/jlr.RA120000767

    authors: Kakino A,Fujita Y,Ke LY,Chan HC,Tsai MH,Dai CY,Chen CH,Sawamura T

    更新日期:2020-11-03 00:00:00

  • New lysosomal acid lipase gene mutants explain the phenotype of Wolman disease and cholesteryl ester storage disease.

    abstract::Deficiency of lysosomal acid lipase (LAL) leads to either Wolman disease (WD) or the more benign cholesteryl ester storage disease (CESD). To identify the molecular basis of the different phenotypes we have characterised the LAL gene mutations in three new patients with LAL deficiency. A patient with WD was homozygote...

    journal_title:Journal of lipid research

    pub_type: 杂志文章

    doi:

    authors: Pagani F,Pariyarath R,Garcia R,Stuani C,Burlina AB,Ruotolo G,Rabusin M,Baralle FE

    更新日期:1998-07-01 00:00:00

  • PPARalpha activation increases triglyceride mass and adipose differentiation-related protein in hepatocytes.

    abstract::Adipose differentiation-related protein (ADRP) is a lipid droplet-associated protein that is expressed in various tissues. In mice treated with the peroxisome proliferator-activated receptor alpha (PPARalpha) agonist Wy14,643 (Wy), hepatic mRNA and protein levels of ADRP as well as hepatic triglyceride content increas...

    journal_title:Journal of lipid research

    pub_type: 杂志文章

    doi:10.1194/jlr.M500203-JLR200

    authors: Edvardsson U,Ljungberg A,Lindén D,William-Olsson L,Peilot-Sjögren H,Ahnmark A,Oscarsson J

    更新日期:2006-02-01 00:00:00

  • ATP binding cassette G1-dependent cholesterol efflux during inflammation.

    abstract::ATP binding cassette transporter G1 (ABCG1) mediates the transport of cellular cholesterol to HDL, and it plays a key role in maintaining macrophage cholesterol homeostasis. During inflammation, HDL undergoes substantial remodeling, acquiring lipid changes and serum amyloid A (SAA) as a major apolipoprotein. In the cu...

    journal_title:Journal of lipid research

    pub_type: 杂志文章

    doi:10.1194/jlr.M012328

    authors: de Beer MC,Ji A,Jahangiri A,Vaughan AM,de Beer FC,van der Westhuyzen DR,Webb NR

    更新日期:2011-02-01 00:00:00

  • Study on the composition-structure relationship of lipophorins.

    abstract::High density lipophorin (HDLp is the main lipoprotein found in resting insect hemolymph. It has, in general, two molecules of apolipoproteins: apoLp-I (250 kDa) and apoLp-II (80 kDa) and a variable lipid content which ranges from 35% to 59% (w/w). Diacylglycerols (DG), phospholipids (PL), and hydrocarbons (HC) are the...

    journal_title:Journal of lipid research

    pub_type: 杂志文章

    doi:

    authors: Soulages JL,Brenner RR

    更新日期:1991-03-01 00:00:00

  • Rat long-chain acyl-CoA synthetase mRNA, protein, and activity vary in tissue distribution and in response to diet.

    abstract::Distinct isoforms of long-chain acyl-CoA synthetases (ACSLs) may partition fatty acids toward specific metabolic cellular pathways. For each of the five members of the rat ACSL family, we analyzed tissue mRNA distributions, and we correlated the mRNA, protein, and activity of ACSL1 and ACSL4 after fasting and refeedin...

    journal_title:Journal of lipid research

    pub_type: 杂志文章

    doi:10.1194/jlr.M600150-JLR200

    authors: Mashek DG,Li LO,Coleman RA

    更新日期:2006-09-01 00:00:00

  • Partition of lipids between emulsified oil and micellar phases of glyceride-bile salt dispersions.

    abstract::The composition of the emulsified oil and of the micellar phases obtained when a glyceride-fatty acid mixture is dispersed in bile salt solution has been defined. The micellar phase in equilibrium with the emulsified oil phase was obtained by filtration through Millipore filters. The behavior of different lipids in su...

    journal_title:Journal of lipid research

    pub_type: 杂志文章

    doi:

    authors: Borgström B

    更新日期:1967-11-01 00:00:00

  • Metabolism of oxysterols derived from nonenzymatic oxidation of 7-dehydrocholesterol in cells.

    abstract::Recent studies suggest that 7-dehydrocholesterol (7-DHC)-derived oxysterols play important roles in the pathophysiology of Smith-Lemli-Opitz syndrome (SLOS), a metabolic disorder that is caused by defective 3β-hydroxysterol-Δ(7)-reductase (DHCR7). Although 14 oxysterols have been identified as the primary products of ...

    journal_title:Journal of lipid research

    pub_type: 杂志文章

    doi:10.1194/jlr.M035733

    authors: Xu L,Korade Z,Rosado DA Jr,Mirnics K,Porter NA

    更新日期:2013-04-01 00:00:00

  • Retroperitoneal white adipose tissue lipoprotein lipase activity is rapidly down-regulated in response to acute stress.

    abstract::Tissue-specific regulation of LPL has been widely studied in rats. Previous studies reported that in vivo administration of adrenaline and acute stress cause an increase in plasma LPL activity coinciding with a decrease in white adipose tissue (WAT) LPL activity. We studied the speed of LPL activity changes during 30 ...

    journal_title:Journal of lipid research

    pub_type: 杂志文章

    doi:10.1194/jlr.M600487-JLR200

    authors: Casanovas A,Parramon N,de la Cruz F,Andrés O,Terencio J,López-Tejero MD,Llobera M

    更新日期:2007-04-01 00:00:00

  • Formation of a complex between valine and intestinal mucosal lipid; its possible role in valine absorption.

    abstract::During intestinal absorption amino acids must traverse the lipid-rich epithelial cell membrane, possibly in a lipid-soluble form. In a search for such a form, we have determined the ability of lipid extracted from intestinal mucosa to bind valine. After incubation in a valine-containing medium this lipid (defined as t...

    journal_title:Journal of lipid research

    pub_type: 杂志文章

    doi:

    authors: Reiser S,Christiansen PA

    更新日期:1968-09-01 00:00:00

  • Lipid metabolism in fatty liver of lysine- and threonine-deficient rats.

    abstract::Rats were fed a low protein diet deficient in and supplemented with lysine and threonine. Liver lipids contained more lecithin, sphingomyelin, and free fatty acids, and less amino phospholipids in the deficient rats. No variations in fatty acid composition of choline- and ethanolamine-containing phospholipids were fou...

    journal_title:Journal of lipid research

    pub_type: 杂志文章

    doi:

    authors: Viviani R,Sechi AM,Lenaz G

    更新日期:1966-07-01 00:00:00

  • Abnormal liver phosphatidylcholine synthesis revealed in patients with acute respiratory distress syndrome.

    abstract::Acute respiratory distress syndrome (ARDS) is associated with a severe pro-inflammatory response; although decreased plasma cholesterol concentration has been linked to systemic inflammation, any association of phospholipid metabolic pathways with ARDS has not been characterized. Plasma phosphatidylcholine (PC), the m...

    journal_title:Journal of lipid research

    pub_type: 杂志文章

    doi:10.1194/jlr.P085050

    authors: Dushianthan A,Cusack R,Grocott MPW,Postle AD

    更新日期:2018-06-01 00:00:00

  • Lipogenesis from glucose and pyruvate in fat cells from genetically obese rats.

    abstract::Subcutaneous fat cells were isolated from genetically obese rats and from rats with obesity produced by hypothalamic lesions. Insulin did not augment the oxidation of fatty acids or their synthesis from glucose-1-(14)C or glucose-1-(3)H by fat cells from either group. Radioactivity from pyruvate-3-(14)C was incorporat...

    journal_title:Journal of lipid research

    pub_type: 杂志文章

    doi:

    authors: Bray GA

    更新日期:1968-11-01 00:00:00

  • Dephosphorylation and benzoylation reactions occurring in the benzoolysis of diacyl-, alkylacyl-, alk-1-enylacyl-, and acyl-lyso-glycerophosphocholines.

    abstract::Series of benzoolysis experiments with 1,2-dipalmitoyl glycerophosphocholine (GPC), 1-palmitoyl-2-lyso GPC, and 1-O-hexadecenyl-2-oleoyl GPC, as well as a few experiments with 1-oleoyl-2-acetyl GPC and 1-O-hexadecyl-2-acetyl GPC are reported. The results are used to present a consistent picture of the various dephosph...

    journal_title:Journal of lipid research

    pub_type: 杂志文章

    doi:

    authors: Gelsema WJ,van den Bosch H

    更新日期:1997-08-01 00:00:00

  • Ca2+-induced fusion of sulfatide-containing phosphatidylethanolamine small unilamellar vesicles.

    abstract::The fusogenic properties of sulfatide-containing 1,2-dioleoyl-3-sn -phosphatidylethanolamine (DOPE) small unilamellar vesicles (SUVs) in the presence of CaCl2 were studied by mixing membrane lipids based on an assay of fluorescence resonance energy transfer (FRET). Fusion of the vesicles was also confirmed by mixing a...

    journal_title:Journal of lipid research

    pub_type: 杂志文章

    doi:

    authors: Wu X,Li QT

    更新日期:1999-07-01 00:00:00

  • Interactions of cholesterol esters with phospholipids: cholesteryl myristate and dimyristoyl lecithin.

    abstract::The ternary phase diagram of cholesteryl myristate--dimyristoyl lecithin--water has been determined by polarizing light microscopy, scanning calorimetry, and x-ray diffraction. Hydrated dimyristoyl lecithin forms a lamellar liquid--crystalline phase (L alpha) at temperatures greater than 23 degrees C into which limite...

    journal_title:Journal of lipid research

    pub_type: 杂志文章

    doi:

    authors: Janiak MJ,Small DM,Shipley GG

    更新日期:1979-02-01 00:00:00

  • Apolipoprotein E metabolism in normolipoproteinemic human subjects.

    abstract::Human apolipoprotein E (apoE) is a constituent of plasma very low density and high density lipoproteins and is important in modulating the catabolism of remnants of triglyceride-rich lipoproteins. There are three common isoforms of apoE, designated apoE-2, E-3, and E-4, which are coded by three separate alleles (epsil...

    journal_title:Journal of lipid research

    pub_type: 杂志文章

    doi:

    authors: Gregg RE,Zech LA,Schaefer EJ,Brewer HB Jr

    更新日期:1984-11-01 00:00:00

  • Effects of legume consumption on serum cholesterol, biliary lipids, and sterol metabolism in humans.

    abstract::Legume consumption appears to lower serum cholesterol and to increase cholesterol saturation of bile, but the mechanisms of these effects have not been established. We studied nine human subjects on a metabolic ward during two randomly ordered 6-7 week periods: one during consumption of a control diet and the other du...

    journal_title:Journal of lipid research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Duane WC

    更新日期:1997-06-01 00:00:00

  • Mechanism of the defect in cholesteryl ester clearance from macrophages of atherosclerosis-susceptible White Carneau pigeons.

    abstract::Recent studies from our laboratory (Yancey, P.G., and R. W. St. Clair. 1992. Arterioscler. Thromb. 12: 1291-1304) have shown that cultured peritoneal macrophages from White Carneau (WC) pigeons clear cholesteryl esters at a slower rate than do macrophages from Show Racer (SR) pigeons (9% per 24 h vs. 42% per 24 h, res...

    journal_title:Journal of lipid research

    pub_type: 杂志文章

    doi:

    authors: Yancey PG,St Clair RW

    更新日期:1994-12-01 00:00:00

  • Effect of retinoids on nuclear retinoic acid receptors mRNA in adipose tissue of retinol-deficient rats.

    abstract::In this study, we examined effects of retinol deficiency and three retinoids, all-trans-retinoic acid, 13-cis-retinoic acid, and etretin, the aromatic derivative of retinoic acid on nuclear retinoic acid receptor isoforms alpha, beta, and gamma mRNA in rat adipose tissue. Retinol deficiency caused an almost 50% decrea...

    journal_title:Journal of lipid research

    pub_type: 杂志文章

    doi:

    authors: Riaz-ul-Haq,Chytil F

    更新日期:1992-03-01 00:00:00

  • Structural requirements of Rhizobium chitolipooligosaccharides for uptake and bioactivity in legume roots as revealed by synthetic analogs and fluorescent probes.

    abstract::Rhizobium chitolipooligosaccharides (CLOSs) are heterogeneous fatty acylated N-acetyl glucosamine oligomers with variations in both the polar (hydrophilic) oligosaccharide head group and the non-polar (hydrophobic) fatty acyl chain. They trigger root hair deformation and cortical cell divisions in legume roots during ...

    journal_title:Journal of lipid research

    pub_type: 杂志文章

    doi:

    authors: Philip-Hollingsworth S,Dazzo FB,Hollingsworth RI

    更新日期:1997-06-01 00:00:00

  • Racial differences in in vivo adipose lipid kinetics in humans.

    abstract::The storage of lipids in the form of triglycerides (TGs) and the de novo synthesis (lipogenesis) of fatty acids from nonlipid precursors [de novo lipogenesis (DNL)] are important functions of adipose tissue (AT) that influence whole-body metabolism. Yet, few studies have reported in vivo estimates of adipose lipid kin...

    journal_title:Journal of lipid research

    pub_type: 杂志文章

    doi:10.1194/jlr.P082628

    authors: White UA,Fitch MD,Beyl RA,Hellerstein MK,Ravussin E

    更新日期:2018-09-01 00:00:00

  • Omega-hydroxylation of phytanic acid in rat liver microsomes: implications for Refsum disease.

    abstract::The 3-methyl-branched fatty acid phytanic acid is degraded by the peroxisomal alpha-oxidation route because the 3-methyl group blocks beta-oxidation. In adult Refsum disease (ARD), peroxisomal alpha-oxidation is defective, which is caused by mutations in the gene coding for phytanoyl-CoA hydroxylase in the majority of...

    journal_title:Journal of lipid research

    pub_type: 杂志文章

    doi:10.1194/jlr.M400064-JLR200

    authors: Komen JC,Duran M,Wanders RJ

    更新日期:2004-07-01 00:00:00

  • Differential uptake of proteoglycan-selected subfractions of low density lipoprotein by human macrophages.

    abstract::Macrophages and arterial chondroitin sulfate proteoglycans (CSPG) are probably associated with extracellular and intracellular lipoprotein deposition during atherogenesis. We found that human arterial CSPG can be used to select subclasses from low density lipoprotein (LDL) with different structural properties and capa...

    journal_title:Journal of lipid research

    pub_type: 杂志文章

    doi:

    authors: Hurt-Camejo E,Camejo G,Rosengren B,Lopez F,Wiklund O,Bondjers G

    更新日期:1990-08-01 00:00:00

  • Effect of long chain polyunsaturated fatty acids in the sn-2 position of phosphatidylcholine on the interaction with recombinant high density lipoprotein apolipoprotein A-I.

    abstract::The effects of polyunsaturated fatty acids (PUFA) on the structure of recombinant high density lipoprotein (rHDL) was investigated using homogeneous particles containing phosphatidylcholine (PC), [3H]cholesterol, and apolipoprotein A-I (apoA-I). The PC component of the rHDL contained sn -1 16:0 and sn -2 18:1 (POPC), ...

    journal_title:Journal of lipid research

    pub_type: 杂志文章

    doi:

    authors: Huggins KW,Curtiss LK,Gebre AK,Parks JS

    更新日期:1998-12-01 00:00:00

  • Lipolysis of very low density lipoproteins by heparan sulfate proteoglycan-bound lipoprotein lipase.

    abstract::An in vitro assay to study lipolysis of very low density lipoproteins (VLDL) by heparan sulfate proteoglycan (HSPG-bound lipoprotein lipase (LPL) was developed. Optimal conditions for VLDL lipolysis by HSPG-bound LPL were obtained by incubating plastic wells with 0.5 microg HSPG and 1.5 microg LPL, subsequently. Contr...

    journal_title:Journal of lipid research

    pub_type: 杂志文章

    doi:

    authors: de Man FH,de Beer F,van der Laarse A,Smelt AH,Havekes LM

    更新日期:1997-12-01 00:00:00

  • Thematic review series: skin lipids. Sebaceous gland lipids: friend or foe?

    abstract::Sebaceous glands are intriguing glands that are found throughout the human body except on the palms of the hands and soles of the feet. The true function of these glands has yet to be determined, but there are several theories, including antioxidant effects, antibacterial effects, and transport of pheromones. Sebaceou...

    journal_title:Journal of lipid research

    pub_type: 杂志文章,评审

    doi:10.1194/jlr.R700015-JLR200

    authors: Smith KR,Thiboutot DM

    更新日期:2008-02-01 00:00:00

  • Diet1, bile acid diarrhea, and FGF15/19: mouse model and human genetic variants.

    abstract::Diet1 modulates intestinal production of the hormone, fibroblast growth factor (FGF)15, which signals in liver to regulate bile acid synthesis. C57BL/6ByJ mice with a spontaneous Diet1-null mutation are resistant to hypercholesterolemia compared with wild-type C57BL/6J mice through enhanced cholesterol conversion to b...

    journal_title:Journal of lipid research

    pub_type: 杂志文章

    doi:10.1194/jlr.M078279

    authors: Lee JM,Ong JR,Vergnes L,de Aguiar Vallim TQ,Nolan J,Cantor RM,Walters JRF,Reue K

    更新日期:2018-03-01 00:00:00