Abstract：
:A dual-indentation creep and stress relaxation methodology was developed and validated for the material characterization of very soft biological tissue within the framework of the biphasic poroviscoelastic (BPVE) constitutive model. Agarose hydrogel, a generic porous medium with mobile fluid, served as a mechanical tissue analogue for validation of the experimental procedure. Indentation creep and stress relaxation tests with a solid plane-ended cylindrical indenter were performed at identical sites on a gel sample with dimensions large enough with respect to indenter size in order to satisfy an infinite layer assumption. A finite element (FE) formulation coupled to a global optimization algorithm was utilized to simultaneously curve-fit the creep and stress relaxation data and extract the BPVE model parameters for the agarose gel. A numerical analysis with artificial data was conducted to validate the uniqueness of the computational procedure. The BPVE model was able to successfully cross-predict both creep and stress relaxation behavior for each pair of experiments with a single unique set of material parameters. Optimized elastic moduli were consistent with those reported in the literature for agarose gel. With the incorporation of appropriately-sized indenters to satisfy more stringent geometric constraints, this simple yet powerful indentation methodology can provide a straightforward means by which to obtain the BPVE model parameters of biological soft tissues that are difficult to manipulate (such as brain and adipose) while maintaining a realistic in situ loading environment.
journal_name
J Biomechjournal_title
Journal of biomechanicsauthors
Olberding JE,Francis Suh JKdoi
10.1016/j.jbiomech.2005.07.019keywords:
subject
Has Abstractpub_date
2006-01-01 00:00:00pages
2468-75issue
13eissn
0021-9290issn
1873-2380pii
S0021-9290(05)00357-Xjournal_volume
39pub_type
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journal_title：Journal of biomechanics
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journal_title：Journal of biomechanics
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journal_title：Journal of biomechanics
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pub_type： 临床试验,杂志文章
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journal_title：Journal of biomechanics
pub_type： 杂志文章,评审
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更新日期：2003-10-01 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2012.06.030
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2013.08.001
更新日期：2013-10-18 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1016/s0021-9290(02)00179-3
更新日期：2002-10-01 00:00:00
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/0021-9290(96)00061-9
更新日期：1996-10-01 00:00:00
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journal_title：Journal of biomechanics
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doi：10.1016/j.jbiomech.2018.04.036
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journal_title：Journal of biomechanics
pub_type： 杂志文章
doi：10.1016/j.jbiomech.2005.03.027
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journal_title：Journal of biomechanics
pub_type： 杂志文章
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journal_title：Journal of biomechanics
pub_type： 临床试验,杂志文章
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journal_title：Journal of biomechanics
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journal_title：Journal of biomechanics
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更新日期：2002-03-01 00:00:00
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journal_title：Journal of biomechanics
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更新日期：2013-08-09 00:00:00
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journal_title：Journal of biomechanics
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