Abstract:
:Congenital amusia is a lifelong disability that prevents afflicted individuals from enjoying music as ordinary people do. The deficit is limited to music and cannot be explained by prior brain lesion, hearing loss, or any cognitive or socio-affective disturbance. Recent behavioral results suggest that this disorder is critically dependent on fine-grained pitch discrimination. Here, we present novel electrophysiological evidence that this disorder can be traced down to a right-lateralized N2-P3 response elicited by pitch changes. This abnormal brain response begins as early as 200 milliseconds after tone onset and may serve as a marker of an anomaly in music acquisition.
journal_name
Ann Neuroljournal_title
Annals of neurologyauthors
Peretz I,Brattico E,Tervaniemi Mdoi
10.1002/ana.20606keywords:
subject
Has Abstractpub_date
2005-09-01 00:00:00pages
478-82issue
3eissn
0364-5134issn
1531-8249journal_volume
58pub_type
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journal_title:Annals of neurology
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更新日期:2013-03-01 00:00:00
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journal_title:Annals of neurology
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doi:10.1002/ana.410130217
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journal_title:Annals of neurology
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journal_title:Annals of neurology
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doi:10.1002/ana.22070
更新日期:2010-09-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410170415
更新日期:1985-04-01 00:00:00
abstract::Six polypeptides resolved by two-dimensional electrophoresis of homogenates from human skeletal muscle have been identified as tropomyosin by electrophoretic and immunochemical methods. The 6 proteins are consistently present in approximately the same abundance in normal biceps, deltoid, gastrocnemius, and quadriceps ...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410180211
更新日期:1985-08-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
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更新日期:1979-12-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.22102
更新日期:2010-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/ana.21113
更新日期:2007-09-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410170117
更新日期:1985-01-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410180109
更新日期:1985-07-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章,随机对照试验
doi:10.1002/ana.22444
更新日期:2011-10-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410170105
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journal_title:Annals of neurology
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doi:10.1002/ana.410250411
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更新日期:2002-02-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410200604
更新日期:1986-12-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.22628
更新日期:2012-06-01 00:00:00
abstract::Magnetic resonance imaging (MRI) provides a powerful tool for assessing disease activity in multiple sclerosis (MS), and its role as a surrogate marker for monitoring treatment efficacy is now becoming established. The most commonly used MRI parameters in treatment trials are (1) monthly gadolinium-enhanced MRI, with ...
journal_title:Annals of neurology
pub_type: 杂志文章,评审
doi:10.1002/ana.410430311
更新日期:1998-03-01 00:00:00
abstract::A recent observation has shown that a common polymorphism in the alpha1-antichymotrypsin (ACT) gene modifies the apolipoprotein E (ApoE) epsilon4-associated Alzheimer's disease (AD) risk identifying the combination of the ACT/AA and ApoE epsilon4/epsilon4 genotypes as a potential susceptibility marker for AD. We analy...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410400420
更新日期:1996-10-01 00:00:00
abstract:OBJECTIVE:Limited evidence is available to guide treatment of depression for persons with epilepsy. We evaluated the comparative effectiveness of sertraline and cognitive behavior therapy (CBT) for depression, quality of life, seizures, and adverse treatment effects. METHODS:We randomly assigned 140 adult outpatients ...
journal_title:Annals of neurology
pub_type: 杂志文章,随机对照试验
doi:10.1002/ana.25561
更新日期:2019-10-01 00:00:00
abstract::Several mutations in the amyloid precursor protein (APP) gene have been found to associate with pathologic deposition of the beta-amyloid peptide (Abeta) in neuritic plaques or in the walls of cerebral vessels. We report a mutation at a novel site in APP in a three-generation Iowa family with autosomal dominant dement...
journal_title:Annals of neurology
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doi:10.1002/ana.1009
更新日期:2001-06-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章,评审
doi:10.1002/ana.21841
更新日期:2010-02-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.20508
更新日期:2005-07-01 00:00:00