Upregulation of Bcl-2 protein in the myasthenic thymus.


:We examined the expression of Fas antigen and Bcl-2 protein in thymic tissue surgically resected from 10 patients with myasthenia gravis, using immunocytochemical techniques. Histologically, thymic tissues from 7 myasthenia gravis patients showed hyperplasia, while 3 other patients had thymomas. In hyperplastic thymic tissue, immunoreactivity for Fas antigen was observed mainly in the network of medullary epithelial cells. In contrast, expression of Fas antigen was rare in the cortex. Fas antigen was also detected to some degree in thymoma tissue from 3 patients. Bcl-2 protein was highly expressed in the medullary thymocytes in the hyperplastic thymic tissue, whereas its staining was quite low in myasthenia gravis thymomas. The number of Bcl-2-positive thymocytes in the medulla was significantly greater in the hyperplastic myasthenia gravis thymic tissue than in the control thymic tissue. These findings suggest that Bcl-2 protein may be upregulated in the myasthenia gravis thymus and that this phenomenon may be related to impaired apoptotic cell death of autoreactive thymocytes in myasthenia gravis.


Ann Neurol


Annals of neurology


Onodera J,Nakamura S,Nagano I,tobita M,Yoshioka M,Takeda A,Oouchi M,Itoyama Y




Has Abstract


1996-04-01 00:00:00












  • In vivo study indicating loss of intracortical inhibition in tumor-associated epilepsy.

    abstract::Transcranial magnetic stimulation was performed in 2 patients with focal motor seizures in the right hand caused by a circumscribed tumor process affecting the left precentral gyrus. In both cases, paired-pulse transcranial magnetic stimulation showed a loss of intracortical inhibition for interstimulus intervals of 2...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Irlbacher K,Brandt SA,Meyer BU

    更新日期:2002-07-01 00:00:00

  • Focal cerebral ischemia in the rat: topography of hemodynamic and histopathological changes.

    abstract::We studied local cerebral blood flow, as measured by autoradiography with digital image processing and by tissue morphology, in six rats 4 hours after occlusion of the proximal middle cerebral artery. A consistent, three-dimensional pattern of graded reductions in local cerebral blood flow involved the affected hemisp...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Tyson GW,Teasdale GM,Graham DI,McCulloch J

    更新日期:1984-06-01 00:00:00

  • Increases in helper inducer T cells and activated T cells in HTLV-I-associated myelopathy.

    abstract::Using two-color flow cytometric analysis, we studied peripheral blood lymphocyte subsets in 15 patients with human T-cell lymphotropic virus type I-associated myelopathy. The percentage of CD4+ 4B4+ cells (helper inducer T cell) was significantly increased in the patients with the myelopathy, compared with 16 healthy ...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Itoyama Y,Kira J,Fujii N,Goto I,Yamamoto N

    更新日期:1989-08-01 00:00:00

  • Outcome of neonatal intraventricular hemorrhage with periventricular echodense lesions.

    abstract::The incidence of periventricular-intraventricular hemorrhage (PV-IVH) in a group of 460 preterm infants with birth weight less than 2,250 gm, studied by cranial ultrasonography, was 39%. Sixty-four (36%) of the infants with periventricular-intraventricular hemorrhage had, in addition, periventricular intraparenchymal ...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: McMenamin JB,Shackelford GD,Volpe JJ

    更新日期:1984-03-01 00:00:00

  • IgG production within the central nervous system: a critical review of proposed formulae.

    abstract::Demonstration of intrathecal IgG production is employed in the diagnosis of various neurological disorders. This pathological IgG fraction in cerebrospinal fluid (CSF) can be visualized directly as oligoclonal bands by electrophoresis or isoelectric focusing or can be calculated as "excess" or "synthesized" IgG accord...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Lefvert AK,Link H

    更新日期:1985-01-01 00:00:00

  • Levodopa induces dyskinesias in normal squirrel monkeys.

    abstract::This study assessed whether or not levodopa induces dyskinesias in normal (ie, unlesioned) squirrel monkeys. All six animals treated twice daily with levodopa (15 mg/kg with carbidopa by oral gavage) for two weeks developed choreoathetoid dyskinesias, whereas none of the vehicle-treated animals displayed any abnormal ...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Togasaki DM,Tan L,Protell P,Di Monte DA,Quik M,Langston JW

    更新日期:2001-08-01 00:00:00

  • Epstein-Barr virus meningoencephalitis with a lymphoma-like response in an immunocompetent host.

    abstract::We report the clinical and neuropathological findings in an immunocompetent 19-year-old patient with a fatal acute Epstein-Barr virus (EBV) meningoencephalitis and a lymphoma-like B-lymphocyte response. Our results suggest that an immunotoxic rather than direct viral neuronal invasion mediates brain damage in EBV ence...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Schellinger PD,Sommer C,Leithäuser F,Schwab S,Storch-Hagenlocher B,Hacke W,Kiessling M

    更新日期:1999-05-01 00:00:00

  • Experimental allergic encephalomyelitis: a misleading model of multiple sclerosis.

    abstract::Despite many years of intensive research, multiple sclerosis (MS) defies understanding and treatment remains suboptimal. The prevailing hypothesis is that MS is immune mediated and that experimental allergic encephalomyelitis (EAE) is a suitable model to elucidate pathogenesis and devise therapy. This review examines ...

    journal_title:Annals of neurology

    pub_type: 杂志文章,评审


    authors: Sriram S,Steiner I

    更新日期:2005-12-01 00:00:00

  • Individual patterns of functional reorganization in the human cerebral cortex after capsular infarction.

    abstract::We have previously shown bilateral activation of motor pathways and the recruitment of additional motor areas in studies of groups of patients with recovery from motor stroke. We have now developed a new positron emission tomographic technique to measure the changes in regional cerebral blood flow elicited during a mo...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Weiller C,Ramsay SC,Wise RJ,Friston KJ,Frackowiak RS

    更新日期:1993-02-01 00:00:00

  • Mesulergine (CU32-085) in the treatment of Parkinson's disease.

    abstract::Twenty patients with Parkinson's disease were treated with the 8-alpha-ergoline derivative mesulergine. Participants were divided into two groups, and over a nine-week period, mesulergine dosage was increased to a maximum of either 10 or 20 mg daily. During this time levodopa-carbidopa (LD-CD) dosage was reduced and t...

    journal_title:Annals of neurology

    pub_type: 临床试验,杂志文章


    authors: Pfeiffer RF,Wilken K,Glaeske C

    更新日期:1985-04-01 00:00:00

  • Stroke prevention in nonvalvular atrial fibrillation: a review of prospective randomized trials.

    abstract::Patients with atrial fibrillation are at risk for cerebral embolism; however, the roles of chronic anticoagulation or antiplatelet therapy for stroke prevention in patients with nonvalvular atrial fibrillation have been controversial. Recently, the results of three large prospective randomized trials that examined the...

    journal_title:Annals of neurology

    pub_type: 杂志文章,评审


    authors: Albers GW,Sherman DG,Gress DR,Paulseth JE,Petersen P

    更新日期:1991-10-01 00:00:00

  • Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet.

    abstract:OBJECTIVE:The full anticonvulsant effect of the ketogenic diet (KD) can require weeks to develop in rats, suggesting that altered gene expression is involved. The KD typically is used in pediatric epilepsies, but is effective also in adolescents and adults. Our goal was to use microarray and complementary technologies ...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Bough KJ,Wetherington J,Hassel B,Pare JF,Gawryluk JW,Greene JG,Shaw R,Smith Y,Geiger JD,Dingledine RJ

    更新日期:2006-08-01 00:00:00

  • Interleukin-6 genotype and risk for cerebral palsy in term and near-term infants.

    abstract:OBJECTIVE:Chorioamnionitis is associated with increased risk for cerebral palsy (CP) in term infants. A functional polymorphism in the interleukin-6 (IL-6) gene has been implicated in newborn brain injury. We studied whether the IL-6 -174 G/C polymorphism confers increased risk for CP in term infants. METHODS:This pop...

    journal_title:Annals of neurology

    pub_type: 杂志文章,随机对照试验


    authors: Wu YW,Croen LA,Torres AR,Van De Water J,Grether JK,Hsu NN

    更新日期:2009-11-01 00:00:00

  • Myelin abnormality in Charcot-Marie-Tooth type 4J recapitulates features of acquired demyelination.

    abstract:OBJECTIVE:Charcot-Marie-Tooth type 4J (CMT4J) is a rare autosomal recessive neuropathy caused by mutations in FIG4 that result in loss of FIG4 protein. This study investigates the natural history and mechanisms of segmental demyelination in CMT4J. METHODS:Over the past 9 years, we have enrolled and studied a cohort of...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Hu B,McCollum M,Ravi V,Arpag S,Moiseev D,Castoro R,Mobley B,Burnette B,Siskind C,Day J,Yawn R,Feely S,Li Y,Yan Q,Shy M,Li J

    更新日期:2018-04-01 00:00:00

  • Upregulation of Fas/Fas ligand in inclusion body myositis.

    abstract::In inclusion body myositis, T cells invade and destroy nonnecrotic muscle fibers. The mechanism by which T cells damage muscle fibers in inflammatory myopathies is not known. In this study we have investigated the expression of Fas and Fas ligand in muscle in five patients with inclusion body myositis. Reverse transcr...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Fyhr IM,Oldfors A

    更新日期:1998-01-01 00:00:00

  • Regenerating and denervated human muscle fibers and satellite cells express neural cell adhesion molecule recognized by monoclonal antibodies to natural killer cells.

    abstract::The monoclonal antibodies anti-Leu-19 and anti-NKH-1 recognize the CD56 differentiation antigen expressed on natural killer (NK) cells and on a T-cell subset. Because CD56 is an isoform of neural cell adhesion molecule (N-CAM), we examined its expression on human muscle using antibodies to Leu-19, NKH-1, and purified ...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Illa I,Leon-Monzon M,Dalakas MC

    更新日期:1992-01-01 00:00:00

  • Physiologic basis of dyskinesia.

    abstract::The current functional model of the basal ganglia suggests that dyskinesia results from abnormally low activity at the output of the system. This view appears incomplete. The recent literature suggests other factors. Thus, dyskinesia may result from disturbance of surround inhibition: a physiologic mechanism to select...

    journal_title:Annals of neurology

    pub_type: 杂志文章,评审


    authors: Filion M

    更新日期:2000-04-01 00:00:00

  • Gene delivery of neurturin to putamen and substantia nigra in Parkinson disease: A double-blind, randomized, controlled trial.

    abstract:OBJECTIVE:A 12-month double-blind sham-surgery-controlled trial assessing adeno-associated virus type 2 (AAV2)-neurturin injected into the putamen bilaterally failed to meet its primary endpoint, but showed positive results for the primary endpoint in the subgroup of subjects followed for 18 months and for several seco...

    journal_title:Annals of neurology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Warren Olanow C,Bartus RT,Baumann TL,Factor S,Boulis N,Stacy M,Turner DA,Marks W,Larson P,Starr PA,Jankovic J,Simpson R,Watts R,Guthrie B,Poston K,Henderson JM,Stern M,Baltuch G,Goetz CG,Herzog C,Kordower JH,Alt

    更新日期:2015-08-01 00:00:00

  • Instrumental neutron activation analysis of brain aluminum in Alzheimer disease and aging.

    abstract::Instrumental neutron activation analysis procedures were used to determine the aluminum content of various brain regions in histologically verified Alzheimer disease (AD) and in controls. The grand mean aluminum level for 74 AD specimens was 0.372 +/- 0.058 microgram/gm and for 137 adult controls, 0.467 +/- 0.033 micr...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Markesbery WR,Ehmann WD,Hossain TI,Alauddin M,Goodin DT

    更新日期:1981-12-01 00:00:00

  • Epilepsia partialis continua: a new manifestation of anti-Hu-associated paraneoplastic encephalomyelitis.

    abstract::We report on 3 anti-Hu-positive patients who presented with clinical and electroencephalographic (EEG) features of epilepsia partialis continua (EPC). Two of the patients had an associated small cell carcinoma. Magnetic resonance imaging (MRI) disclosed a hyperintense nonenhancing focal lesion in T2-weighted images in...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Shavit YB,Graus F,Probst A,Rene R,Steck AJ

    更新日期:1999-02-01 00:00:00

  • Endoneurial fluid pressure in wallerian degeneration.

    abstract::Endoneurial fluid pressure (EFP) was recorded by an active, servo-null pressure system after a glass micropipette was inserted into rat sciatic nerve undergoing wallerian degeneration. The lesions were produced by crushing the left sciatic nerve of the anesthetized animal at its point of entry into the thigh. Eighty-f...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Powell HC,Myers RR,Costello ML,Lampert PW

    更新日期:1979-06-01 00:00:00

  • Damage to dopamine systems differs between Parkinson's disease and Alzheimer's disease with parkinsonism.

    abstract::Parkinsonism occurs in approximately 35 to 40% of patients with Alzheimer's disease (AD) even with little or no neuronal degeneration in the substantia nigra, which in idiopathic Parkinson's disease (PD) results in the severe loss of striatal dopamine transporter sites. It is not known if there is a loss of striatal d...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Murray AM,Weihmueller FB,Marshall JF,Hurtig HI,Gottleib GL,Joyce JN

    更新日期:1995-03-01 00:00:00

  • Appropriate number of plasma exchanges in Guillain-Barré syndrome. The French Cooperative Group on Plasma Exchange in Guillain-Barré Syndrome.

    abstract::Plasma exchange (PE) is the standard treatment in Guillain-Barré syndrome (GBS) patients who have lost the ability to walk. The effect of exchanges before this stage and the optimal number of exchanges for the other patients are still unknown. We randomized 556 GBS patients according to severity and number of exchange...

    journal_title:Annals of neurology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验



    更新日期:1997-03-01 00:00:00

  • Clinical and genetic spectrum of pyruvate dehydrogenase deficiency: dihydrolipoamide acetyltransferase (E2) deficiency.

    abstract::Pyruvate dehydrogenase deficiency is a major cause of primary lactic acidosis and neurological dysfunction in infancy and early childhood. Most cases are caused by mutations in the X-linked gene for the E1alpha subunit of the complex. Mutations in DLAT, the gene encoding dihydrolipoamide acetyltransferase, the E2 core...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Head RA,Brown RM,Zolkipli Z,Shahdadpuri R,King MD,Clayton PT,Brown GK

    更新日期:2005-08-01 00:00:00

  • New innovations: therapeutic opportunities for intellectual disabilities.

    abstract::Intellectual disability is common and is associated with significant morbidity. Until the latter half of the 20th century, there were no efficacious treatments. Following initial breakthroughs associated with newborn screening and metabolic corrections, little progress was made until recently. With improved understand...

    journal_title:Annals of neurology

    pub_type: 杂志文章,评审


    authors: Picker JD,Walsh CA

    更新日期:2013-09-01 00:00:00

  • Childhood socioeconomic status and adult brain size: childhood socioeconomic status influences adult hippocampal size.

    abstract:OBJECTIVE:To investigate in older adults without dementia the relationships between socioeconomic status (SES) in childhood and magnetic resonance imaging (MRI)-derived brain volume measures typical of brain aging and Alzheimer's disease (AD). METHODS:Using a cross-sectional and longitudinal observation approach, we i...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Staff RT,Murray AD,Ahearn TS,Mustafa N,Fox HC,Whalley LJ

    更新日期:2012-05-01 00:00:00

  • Sequence heterogeneity of HTLV-I proviral DNA in the central nervous system of patients with HTLV-I-associated myelopathy.

    abstract::The nucleotide sequence of human T-lymphotropic virus type I (HTLV-I) in central nervous system tissue was determined in 3 autopsy cases with HTLV-I-associated myelopathy (HAM)/tropical spastic paraparesis (TSP) and 1 seropositive carrier without HAM/TSP but with multiple sclerosis. All HAM/TSP samples (3 spinal cords...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Kira J,Koyanagi Y,Yamada T,Itoyama Y,Tateishi J,Akizuki S,Kishikawa M,Baba E,Nakamura M,Suzuki J

    更新日期:1994-08-01 00:00:00

  • Alzheimer's disease and Parkinson's disease: distinct entities or extremes of a spectrum of neurodegeneration?

    abstract::Alzheimer's disease (AD) and Parkinson's disease (PD) are generally considered to be separate and distinct disease entities. However, a considerable amount of evidence demonstrates that these disorders share common clinical and neuropathologic features and that overlap between the two conditions is extensive. For exam...

    journal_title:Annals of neurology

    pub_type: 杂志文章,评审


    authors: Perl DP,Olanow CW,Calne D

    更新日期:1998-09-01 00:00:00

  • Decreased sympathetic neuronal uptake in idiopathic orthostatic hypotension.

    abstract::The disappearance rates from plasma of intravenously administered levo-norepinephrine (l-NE), dextro-norepinephrine (d-NE), and isoproterenol (ISO) were measured in normal subjects and in patients with either multiple-system atrophy (MSA) or idiopathic orthostatic hypotension (IOH). The two isomers, l-NE and d-NE, wer...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Polinsky RJ,Goldstein DS,Brown RT,Keiser HR,Kopin IJ

    更新日期:1985-07-01 00:00:00

  • Localization of magnetic interictal discharges in temporal lobe epilepsy.

    abstract::Three young adults with intractable complex partial seizures were studied by electroencephalography, magnetoencephalography, and electrocorticography. Interictal electroencephalographic (EEG) spikes for each patient were grouped according to their morphological characteristics and distribution across channels. Mapping...

    journal_title:Annals of neurology

    pub_type: 杂志文章


    authors: Rose DF,Sato S,Smith PD,Porter RJ,Theodore WH,Friauf W,Bonner R,Jabbari B

    更新日期:1987-09-01 00:00:00