Correlations between monthly enhanced MRI lesion rate and changes in T2 lesion volume in multiple sclerosis.

Abstract:

:Magnetic resonance imaging (MRI) provides a powerful tool for assessing disease activity in multiple sclerosis (MS), and its role as a surrogate marker for monitoring treatment efficacy is now becoming established. The most commonly used MRI parameters in treatment trials are (1) monthly gadolinium-enhanced MRI, with the number of active lesions serving as the outcome measure, and (2) annual lesion load quantification, in which change in MS lesion volume provides the MRI endpoint. We evaluated clinical/MRI correlations and the relationship between these two markers of disease activity in 73 patients with clinically definite MS. Quantification of T2 lesion load was performed at study entry and exit, with a median study duration of 11 months (range, 9 to 14 months). Monthly postgadolinium T1-weighted images were acquired between these time points. Lesion load at study entry was significantly correlated with the baseline Expanded Disability Status Scale (EDSS) score, but no significant longitudinal correlation was demonstrated. The number of enhancing lesions on the entry scan was predictive of subsequent relapse rate over the study duration and also correlated with the subsequent enhancing lesion activity over the study period. A significant correlation was found between change in lesion load and disease activity on the monthly scans. Our results suggest that annual lesion load quantification provides an efficient measure of ongoing disease activity, and this supports its application as a surrogate marker of disease evolution in phase III treatment trials.

journal_name

Ann Neurol

journal_title

Annals of neurology

authors

Molyneux PD,Filippi M,Barkhof F,Gasperini C,Yousry TA,Truyen L,Lai HM,Rocca MA,Moseley IF,Miller DH

doi

10.1002/ana.410430311

subject

Has Abstract

pub_date

1998-03-01 00:00:00

pages

332-9

issue

3

eissn

0364-5134

issn

1531-8249

journal_volume

43

pub_type

杂志文章,评审
  • The authorship lottery: an impediment to research collaboration?

    abstract::Authorship of scientific publications holds great importance for basic and clinical researchers. Academic appointments and promotions, grant funding, and salary support depend to some extent on published recognition through authorship. Peer-recognition and personal satisfaction are additional incentives for authorship...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.22232

    authors: Kaufmann P,Annis C,Griggs RC,Muscle Study Group Executive Committee.

    更新日期:2010-12-01 00:00:00

  • Individual patterns of functional reorganization in the human cerebral cortex after capsular infarction.

    abstract::We have previously shown bilateral activation of motor pathways and the recruitment of additional motor areas in studies of groups of patients with recovery from motor stroke. We have now developed a new positron emission tomographic technique to measure the changes in regional cerebral blood flow elicited during a mo...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410330208

    authors: Weiller C,Ramsay SC,Wise RJ,Friston KJ,Frackowiak RS

    更新日期:1993-02-01 00:00:00

  • Natural history of multiple sclerosis.

    abstract::Multiple sclerosis (MS) is the most common idiopathic inflammatory disease of the central nervous system. The distinction between MS and other benign or fulminant inflammatory demyelinating disorders is based on quantitative, rather than qualitative, differences in chronicity and severity. Primary progressive MS may d...

    journal_title:Annals of neurology

    pub_type: 杂志文章,评审

    doi:10.1002/ana.410360704

    authors: Weinshenker BG

    更新日期:1994-01-01 00:00:00

  • Evidence-based path to newborn screening for Duchenne muscular dystrophy.

    abstract:OBJECTIVE:Creatine kinase (CK) levels are increased on dried blood spots in newborns related to the birthing process. As a marker for newborn screening, CK in Duchenne muscular dystrophy (DMD) results in false-positive testing. In this report, we introduce a 2-tier system using the dried blood spot to first assess CK w...

    journal_title:Annals of neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/ana.23528

    authors: Mendell JR,Shilling C,Leslie ND,Flanigan KM,al-Dahhak R,Gastier-Foster J,Kneile K,Dunn DM,Duval B,Aoyagi A,Hamil C,Mahmoud M,Roush K,Bird L,Rankin C,Lilly H,Street N,Chandrasekar R,Weiss RB

    更新日期:2012-03-01 00:00:00

  • Alzheimer-related neuronal protein A68: specificity and distribution.

    abstract::We previously reported that the monoclonal antibody Alz-50 recognizes a protein (A68) with an apparent molecular weight of 68,000 daltons in the brains of patients who died with Alzheimer's disease, but not in brain tissue from individuals free of neurological disease. We now report that substantial quantities of this...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410220412

    authors: Wolozin B,Davies P

    更新日期:1987-10-01 00:00:00

  • Evidence for mitochondrial dysfunction in patients with alternating hemiplegia of childhood.

    abstract::Phosphorus magnetic resonance spectra of resting muscle were obtained from 4 patients with alternating hemiplegia of childhood. All patients had abnormally high resonance intensities from inorganic phosphate and an abnormally low calculated cytosolic phosphorylation potential. Two of the 4 patients had abnormally low ...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410330608

    authors: Arnold DL,Silver K,Andermann F

    更新日期:1993-06-01 00:00:00

  • Sex differences in cell death.

    abstract::Female patients experience substantial neuroprotection after experimental stroke compared with male patients, a finding attributed to the protective effects of gonadal hormones. This study examined the response of male- and female-derived organotypic hippocampal slices to oxidative and excitotoxic injury. Both oxygen ...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.20538

    authors: Li H,Pin S,Zeng Z,Wang MM,Andreasson KA,McCullough LD

    更新日期:2005-08-01 00:00:00

  • Regional metabolic changes in the spinal cord related to spinal shock and later hyperreflexia in monkeys.

    abstract::The regional metabolic rate for glucose (rMRglu) was studied in macaque monkeys after spinal cord transection at T10, both during spinal shock and after reflexes had returned. The rMRglu was measured in all Rexed layers in cord segments both caudal and rostral to the level of the transection utilizing the quantitative...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410140106

    authors: Schwartzman RJ,Eidelberg E,Alexander GM,Yu J

    更新日期:1983-07-01 00:00:00

  • Friedreich's ataxia: clinical pilot trial with recombinant human erythropoietin.

    abstract::To determine the role of recombinant human erythropoietin as a possible treatment option in Friedreich's ataxia, we performed an open-label clinical pilot study. Primary outcome measure was the change of frataxin levels at week 8 versus baseline. Twelve Friedreich's ataxia patients received 5,000 units recombinant hum...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.21177

    authors: Boesch S,Sturm B,Hering S,Goldenberg H,Poewe W,Scheiber-Mojdehkar B

    更新日期:2007-11-01 00:00:00

  • Perfusion-Dependent Cerebral Autoregulation Impairment in Hemispheric Stroke.

    abstract:OBJECTIVE:Loss of cerebral autoregulation (CA) plays a key role in secondary neurologic injury. However, the regional distribution of CA impairment after acute cerebral injury remains unclear because, in clinical practice, CA is only assessed within a limited compartment. Here, we performed large-scale regional mapping...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.25963

    authors: Hecht N,Schrammel M,Neumann K,Müller MM,Dreier JP,Vajkoczy P,Woitzik J

    更新日期:2021-02-01 00:00:00

  • Early seizures after temporal lobectomy predict subsequent seizure recurrence.

    abstract::Patients are understandably anxious if seizures occur immediately after temporal lobectomy. Such "neighborhood" seizures are commonly regarded as irrelevant to seizure outcome and discounted in outcome measurement. We conducted an in-depth examination of early postoperative seizures (<28 days) and outcome. The risk of...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.20372

    authors: McIntosh AM,Kalnins RM,Mitchell LA,Berkovic SF

    更新日期:2005-02-01 00:00:00

  • Comparative cranial CT enhancement in a primate model of cerebral infarction.

    abstract::The value of various enhancement techniques as opposed to nonenhanced CT scanning was compared in 15 baboons with cerebral infarction secondary to embolization of the left middle cerebral artery. The most prominent CT findings in infarction included an area of low absorption in the opercula--basal ganglia--centrum sem...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410050108

    authors: Drayer BP,Dujovny M,Wolfson SK Jr,Boehnke M,Cook EE,Rosenbaum AE

    更新日期:1979-01-01 00:00:00

  • Congenital lymphocytic choriomeningitis virus infection: spectrum of disease.

    abstract:OBJECTIVE:Lymphocytic choriomeningitis virus (LCMV) is a human pathogen and an emerging neuroteratogen. When the infection occurs during pregnancy, the virus can target and damage the fetal brain and retina. We examined the spectrum of clinical presentations, neuroimaging findings, and clinical outcomes of children wit...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.21161

    authors: Bonthius DJ,Wright R,Tseng B,Barton L,Marco E,Karacay B,Larsen PD

    更新日期:2007-10-01 00:00:00

  • Animal models and therapeutic prospects for Charcot-Marie-Tooth disease.

    abstract::Charcot-Marie-Tooth (CMT) neuropathies are inherited neuromuscular disorders caused by a length-dependent neurodegeneration of peripheral nerves. More than 900 mutations in 60 different genes are causative of the neuropathy. Despite significant progress in therapeutic strategies, the disease remains incurable. The inc...

    journal_title:Annals of neurology

    pub_type: 杂志文章,评审

    doi:10.1002/ana.23987

    authors: Bouhy D,Timmerman V

    更新日期:2013-09-01 00:00:00

  • Prospective, open-label safety study of intravenous recombinant tissue plasminogen activator in wake-up stroke.

    abstract:OBJECTIVE:It is estimated that one of four ischemic strokes are noticed upon awakening and are not candidates for intravenous recombinant tissue plasminogen activator (rtPA) because their symptoms are >3 hours from last seen normal (LSN). We tested the safety of rtPA in a multicenter, single-arm, prospective, open-labe...

    journal_title:Annals of neurology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1002/ana.24700

    authors: Barreto AD,Fanale CV,Alexandrov AV,Gaffney KC,Vahidy FS,Nguyen CB,Sarraj A,Rahbar M,Grotta JC,Savitz SI,Wake-Up Stroke Investigators.

    更新日期:2016-08-01 00:00:00

  • Penumbral tissue alkalosis in focal cerebral ischemia: relationship to energy metabolism, blood flow, and steady potential.

    abstract::The effect of focal ischemia on tissue pH was studied at various times up to 6 hours after permanent middle cerebral artery occlusion in rats. Tissue pH was imaged by using umbelliferone fluorescence and correlated with cerebral blood flow, ATP content, and recordings of the steady potential. Circumscribed foci of all...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:

    authors: Back T,Hoehn M,Mies G,Busch E,Schmitz B,Kohno K,Hossmann KA

    更新日期:2000-04-01 00:00:00

  • Regional distribution of protease-resistant prion protein in fatal familial insomnia.

    abstract::Protease-resistant prion protein, total prion protein, and glial fibrillary acidic protein were measured in various brain regions from 9 subjects with fatal familial insomnia. Six were homozygotes methionine/methionine at codon 129 (mean duration, 10.7 +/- 4 months) and 3 were heterozygotes methionine/valine (mean dur...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410380107

    authors: Parchi P,Castellani R,Cortelli P,Montagna P,Chen SG,Petersen RB,Manetto V,Vnencak-Jones CL,McLean MJ,Sheller JR

    更新日期:1995-07-01 00:00:00

  • Endemic tropical spastic paraparesis associated with human T-lymphotropic virus type I: a clinical and seroepidemiological study of 25 cases.

    abstract::Tropical spastic paraparesis (TSP) is a common myeloneuropathy with primary and predominant involvement of the pyramidal tract and minimal sensory loss. The epidemic form of TSP is related to toxic nutritional factors, but the endemic form occurs in clusters in tropical areas, especially in India, Africa, the Seychell...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410210204

    authors: Vernant JC,Maurs L,Gessain A,Barin F,Gout O,Delaporte JM,Sanhadji K,Buisson G,de-Thé G

    更新日期:1987-02-01 00:00:00

  • Chronic idiopathic anhidrosis.

    abstract::We describe the cases of eight patients with chronic idiopathic anhidrosis. These patients were heat intolerant and became hot, flushed, dizzy, dyspneic, and weak but did not sweat when the ambient temperature was high or when they exercised. Four patients had preganglionic sudomotor lesions and in the remaining 4 the...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410180312

    authors: Low PA,Fealey RD,Sheps SG,Su WP,Trautmann JC,Kuntz NL

    更新日期:1985-09-01 00:00:00

  • Descending paralysis resulting from occult wound botulism.

    abstract::A 30-year-old male drug abuser developed ophthalmoplegia, bulbar paralysis, and limb weakness responsive to edrophonium. However, potentiation of a low-amplitude evoked muscle action potential was produced with repetitive nerve stimulation at 10 Hz, and the clinical and electrophysiological data suggested the diagnosi...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410160314

    authors: Rapoport S,Watkins PB

    更新日期:1984-09-01 00:00:00

  • Alzheimer neurofibrillary tangles in diseases other than senile and presenile dementia.

    abstract::A brief description is given of neurofibrillary changes of the paired helical filament type in a variety of chronic neurological diseases. These include subacute sclerosing panencephalitis, lead encephalopathy, tuberous sclerosis, Down syndrome, Hallervorden-Spatz disease, and lipofuscinosis. In these conditions, with...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410050311

    authors: Wisniewski K,Jervis GA,Moretz RC,Wisniewski HM

    更新日期:1979-03-01 00:00:00

  • Involvement of medullary serotonergic groups in multiple system atrophy.

    abstract::We sought to determine whether medullary serotonergic neurons were affected in multiple system atrophy (MSA). Immunostaining for tryptophan hydroxylase was performed on serial 50 microm sections of the medulla of brains obtained at autopsy from six control subjects, eight subjects with clinical diagnosis of MSA, and f...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.20021

    authors: Benarroch EE,Schmeichel AM,Low PA,Parisi JE

    更新日期:2004-03-01 00:00:00

  • Dyslexia: regional differences in brain electrical activity by topographic mapping.

    abstract::Electroencephalographic (EEG) and evoked potential data were recorded during behavioral testing from 8 dyslexic and 10 normal boys aged 9 to 11 years. Topographic mapping of their brain electrical activity revealed four discrete regions of difference between the two groups involving both hemispheres, left more than ri...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410070505

    authors: Duffy FH,Denckla MB,Bartels PH,Sandini G

    更新日期:1980-05-01 00:00:00

  • Synergistic immunomodulatory effects of interferon-beta1b and the phosphodiesterase inhibitor pentoxifylline in patients with relapsing-remitting multiple sclerosis.

    abstract::Subcutaneous application of interferon-beta1b (IFN-beta1b) is an established therapy for patients with relapsing-remitting multiple sclerosis (RRMS), but early side effects are still a major concern. In vitro studies with myelin basic protein (MBP)-specific T-cell lines revealed a synergistic suppressive effect of IFN...

    journal_title:Annals of neurology

    pub_type: 临床试验,杂志文章

    doi:10.1002/ana.410440109

    authors: Weber F,Polak T,Günther A,Kubuschok B,Janovskaja J,Bitsch A,Poser S,Rieckmann P

    更新日期:1998-07-01 00:00:00

  • Neocortical hyperexcitability in a human case of tuberous sclerosis complex and mice lacking neuronal expression of TSC1.

    abstract:OBJECTIVE:To identify brain regions, cell types, or both that generate abnormal electrical discharge in tuberous sclerosis complex (TSC). Here we examined excitatory and inhibitory synaptic currents in human tissue samples obtained from a TSC patient with no discernible cortical tubers and acute neocortical brain slice...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.21058

    authors: Wang Y,Greenwood JS,Calcagnotto ME,Kirsch HE,Barbaro NM,Baraban SC

    更新日期:2007-02-01 00:00:00

  • Clinical and genetic spectrum of pyruvate dehydrogenase deficiency: dihydrolipoamide acetyltransferase (E2) deficiency.

    abstract::Pyruvate dehydrogenase deficiency is a major cause of primary lactic acidosis and neurological dysfunction in infancy and early childhood. Most cases are caused by mutations in the X-linked gene for the E1alpha subunit of the complex. Mutations in DLAT, the gene encoding dihydrolipoamide acetyltransferase, the E2 core...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.20550

    authors: Head RA,Brown RM,Zolkipli Z,Shahdadpuri R,King MD,Clayton PT,Brown GK

    更新日期:2005-08-01 00:00:00

  • Long-term treatment response and fluorodopa positron emission tomographic scanning of parkinsonism in a family with dopa-responsive dystonia.

    abstract::Dopa-responsive dystonia (DRD) is one form of childhood-onset idiopathic torsion dystonia. Adult-onset parkinsonism has appeared in several previously unaffected members in families with DRD suggesting that this may be an additional phenotypical expression of the disease. We report a family with DRD in which 2 women a...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410320502

    authors: Nygaard TG,Takahashi H,Heiman GA,Snow BJ,Fahn S,Calne DB

    更新日期:1992-11-01 00:00:00

  • Endoneurial fluid pressure in wallerian degeneration.

    abstract::Endoneurial fluid pressure (EFP) was recorded by an active, servo-null pressure system after a glass micropipette was inserted into rat sciatic nerve undergoing wallerian degeneration. The lesions were produced by crushing the left sciatic nerve of the anesthetized animal at its point of entry into the thigh. Eighty-f...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.410050610

    authors: Powell HC,Myers RR,Costello ML,Lampert PW

    更新日期:1979-06-01 00:00:00

  • Alpha-synuclein pathology does not predict extrapyramidal symptoms or dementia.

    abstract::Intracytoplasmic aggregation of alpha-synuclein protein as Lewy bodies in the brainstem neurons is diagnostic for Parkinson's disease, whereas if this process also occurs in the cortical neurons, it is considered pathognomonic for dementia with Lewy bodies. However, the link between alpha-synuclein incorporation into ...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.20321

    authors: Parkkinen L,Kauppinen T,Pirttilä T,Autere JM,Alafuzoff I

    更新日期:2005-01-01 00:00:00

  • Associations between cerebrovascular risk factors and parkinson disease.

    abstract:OBJECTIVE:To determine whether cerebrovascular risk factors are associated with subsequent diagnoses of Parkinson disease, and whether these associations are similar in magnitude to those with subsequent diagnoses of Alzheimer disease. METHODS:This was a retrospective cohort study using claims data from a 5% random sa...

    journal_title:Annals of neurology

    pub_type: 杂志文章

    doi:10.1002/ana.25564

    authors: Kummer BR,Diaz I,Wu X,Aaroe AE,Chen ML,Iadecola C,Kamel H,Navi BB

    更新日期:2019-10-01 00:00:00