Abstract:
:Huntington's disease is a genetic disorder that causes motor dysfunction, personality changes, dementia, and premature death. There is currently no effective therapy. Several transgenic models of Huntington's disease are available, the most widely used of which is the R6/2 mouse, because of its rapid disease progression. Environmental enrichment alters gene expression in the normal mouse brain, and modulates the course of several neurological disorders. Environmentally enriched mice may actually mimic human disease more accurately. We found that even limited environmental enrichment slows decline in RotaRod performance in R6/2 mice, despite rapid disease progression, whereas in normal littermates, maximal enrichment was required to induce a marked improvement in behavioral tests. Enrichment also delayed the loss of peristriatal cerebral volume in R6/2 brains. These results could provide the basis for a rational approach to ameliorate the effects of Huntington's disease.
journal_name
Ann Neuroljournal_title
Annals of neurologyauthors
Hockly E,Cordery PM,Woodman B,Mahal A,van Dellen A,Blakemore C,Lewis CM,Hannan AJ,Bates GPdoi
10.1002/ana.10094keywords:
subject
Has Abstractpub_date
2002-02-01 00:00:00pages
235-42issue
2eissn
0364-5134issn
1531-8249pii
10.1002/ana.10094journal_volume
51pub_type
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journal_title:Annals of neurology
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journal_title:Annals of neurology
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journal_title:Annals of neurology
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journal_title:Annals of neurology
pub_type: 临床试验,杂志文章
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journal_title:Annals of neurology
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doi:10.1002/ana.410290119
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410350522
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pub_type: 杂志文章
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doi:10.1002/ana.24749
更新日期:2016-10-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.25564
更新日期:2019-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/ana.410430321
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pub_type: 临床试验,杂志文章
doi:10.1002/ana.21965
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pub_type: 临床试验,杂志文章
doi:10.1002/ana.410140107
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410420211
更新日期:1997-08-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410220412
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410120411
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journal_title:Annals of neurology
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1002/1531-8249(199906)45:6<778::aid-ana12>3.0.c
更新日期:1999-06-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
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更新日期:1994-04-01 00:00:00
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doi:10.1002/ana.23951
更新日期:2013-09-01 00:00:00
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journal_title:Annals of neurology
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更新日期:2013-07-01 00:00:00
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更新日期:2020-12-03 00:00:00
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journal_title:Annals of neurology
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pub_type: 杂志文章
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更新日期:1978-02-01 00:00:00