Evidence for persistence of adenovirus in the tear film a decade following conjunctivitis.

Abstract:

:Chronic papillary conjunctivitis has been described following adenoviral conjunctivitis. It is unknown however, how long adenovirus is able to persist in the tear film and conjunctiva. To determine if adenovirus persists in the ocular surface following adenoviral conjunctivitis, 304 patients with a history of adenovirus conjunctivitis from whom an adenovirus had been isolated 10 years previously were sent a questionnaire regarding persistent or recurrent symptoms and were invited to attend. Patients were examined and samples of tears and conjunctival cells were collected from both eyes using tear film washes, filter paper, and swabs, the latter for virus isolation. Extracted DNA from the ocular samples was amplified using primers for herpes simplex virus (thymidine kinase) and adenovirus (hexon) genes. Adenovirus amplicons were sequenced and compared to original serotype. Thirty patients attended, 19 of whom had persistent papillary conjunctivitis. Evidence of adenovirus DNA was detected in 17 of 30 patients, 15 of whom also had evidence of a chronic papillary conjunctivitis. Adenovirus DNA was significantly associated with papillary conjunctivitis (P = 0.03). Adenovirus amplicons were successfully sequenced from six patients. Four patients harbored type 3 adenovirus, the same serotype with which they were infected originally 10 years previously. Two patients were infected originally with adenovirus serotype 3 but the current serotype was type 4. Infection of the ocular surface with adenovirus may predispose to the development of a persistent or recurrent conjunctivitis, the presence of which, appears to be associated with evidence of long term persistence of adenovirus DNA.

journal_name

J Med Virol

authors

Kaye SB,Lloyd M,Williams H,Yuen C,Scott JA,O'Donnell N,Batterbury M,Hiscott P,Hart CA

doi

10.1002/jmv.20440

keywords:

subject

Has Abstract

pub_date

2005-10-01 00:00:00

pages

227-31

issue

2

eissn

0146-6615

issn

1096-9071

journal_volume

77

pub_type

杂志文章
  • Changes in the hemagglutinins and neuraminidases of human influenza B viruses isolated in Italy during the 2001-02, 2002-03, and 2003-04 seasons.

    abstract::Throughout most of the last decade, B/Yamagata/16/88-lineage influenza viruses were predominant among the B isolates circulating worldwide, whereas B/Victoria/2/87-lineage viruses were isolated infrequently and restricted geographically to eastern Asia. During the 2001-02 influenza season, B/Victoria/2/87-lineage viru...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20225

    authors: Puzelli S,Frezza F,Fabiani C,Ansaldi F,Campitelli L,Lin YP,Gregory V,Bennett M,D'Agaro P,Campello C,Crovari P,Hay A,Donatelli I

    更新日期:2004-12-01 00:00:00

  • ITPA gene polymorphism (94C>A) effects on ribavirin-induced anemia during therapy in Egyptian patients with chronic hepatitis C.

    abstract::Inosine triphosphatase (ITPA) gene variants can protect against ribavirin (RBV)-induced anemia in patients treated for chronic hepatitis C. The aim of this study was to determine the relationship between genetic variants of ITPA polymorphism, anemia, RBV dose reduction, and treatment response in hepatitis C virus (HCV...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24844

    authors: El Raziky M,Zayed NA,Abdel Baki A,Mansour SA,Shahin RMH

    更新日期:2017-10-01 00:00:00

  • Antibody assays for varicella-zoster virus: comparison of competitive enzyme-linked immunosorbent assay (ELISA), competitive radioimmunoassay (RIA), complement fixation, and indirect immunofluorescence assays.

    abstract::The competitive ELISA test was compared with competitive RIA, complement fixation, and indirect fluorescent antibody test for the detection of antibody to varicella-zoster virus (VZV). ELISA and RIA were the most sensitive tests, being tenfold as sensitive as indirect immunofluorescence and 20 times as sensitive as co...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890130407

    authors: Wreghitt TG,Tedder RS,Nagington J,Ferns RB

    更新日期:1984-01-01 00:00:00

  • HBeAg-negative chronic hepatitis patients should be monitored more strictly: a cross-sectional retrospective study on antiviral treatment-naïve patients.

    abstract:AIM:To investigate the prevalence and characteristics of hepatitis B e antigen (HBeAg) negative/treatment naïve subjects with low hepatitis B virus (HBV) DNA levels (<10(4)  copies/ml) and low alanine aminotransferase (ALT) levels (<2 × upper limit of normal) in patients with HBV-related hepatocellular carcinoma (HCC)....

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24217

    authors: Zeng DW,Dong J,Zhang JM,Zhu YY,Jiang JJ,Liu YR

    更新日期:2015-10-01 00:00:00

  • Asymptomatic reactivation and shed of infectious varicella zoster virus in astronauts.

    abstract::Varicella zoster virus (VZV) causes varicella (chickenpox), after which virus becomes latent in ganglia along the entire neuraxis. Virus reactivation produces zoster (shingles). Infectious VZV is found in vesicles of patients with zoster and varicella, but virus shed in the absence of disease has not been documented. ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21173

    authors: Cohrs RJ,Mehta SK,Schmid DS,Gilden DH,Pierson DL

    更新日期:2008-06-01 00:00:00

  • Failure in initial stage containment of global COVID-19 epicenters.

    abstract::With multiple virus epicenters, COVID-19 has been declared a pandemic by the World Health Organization. Consequently, many countries have implemented different policies to manage this crisis including curfew and lockdown. However, the efficacy of individual policies remains unclear with respect to COVID-19 case develo...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25883

    authors: Khosrawipour V,Lau H,Khosrawipour T,Kocbach P,Ichii H,Bania J,Mikolajczyk A

    更新日期:2020-07-01 00:00:00

  • Detection and identification of Toscana and other phleboviruses by RT-nested-PCR assays with degenerated primers.

    abstract::Phleboviruses are a large and widespread group of viruses that are transmitted by arthropods. Toscana virus is one of the principal agents that causes meningitis in humans during the summer in Italy and, possibly, in other Mediterranean countries. Rift Valley Fever virus can cause serious illness in both animals and h...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10465

    authors: Sánchez-Seco MP,Echevarría JM,Hernández L,Estévez D,Navarro-Marí JM,Tenorio A

    更新日期:2003-09-01 00:00:00

  • Coronavirus-like particles in adults in Melbourne, Australia.

    abstract::Coronavirus-like particle(s) (CVLP) are faecal-derived pleomorphic membrane bound virus-like particles characterised by a fringe of club-shaped spikes that measure about 27 nm in length. The association of CVLP with a variety of social, clinical, and epidemiological factors was examined after a 69 month survey of faec...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890290404

    authors: Marshall JA,Thompson WL,Gust ID

    更新日期:1989-12-01 00:00:00

  • Prevalence of delta agent among Chinese in Taiwan and Los Angeles.

    abstract::The prevalence of delta agent among 120 Chinese patients with HBsAg-positive chronic active and hepatocellular carcinoma from Taiwan and Los Angeles were studied by serological assay for antibody to delta antigen and immunoperoxidase staining for delta antigen in the liver biopsies. Of 120 patients, only four with chr...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890140106

    authors: Govindarajan S,Lee SD,Tong MJ,Tsai YT,Lo KJ

    更新日期:1984-01-01 00:00:00

  • Evidence of shared Epstein-Barr viral isolates between sexual partners, and low level EBV in genital secretions.

    abstract::Epstein-Barr virus is present in the saliva of most persistently infected individuals and is generally thought to be spread by close oral contact. However, there are now several reports of EBV in genital secretions, suggesting the possibility of sexual transmission between adults. The present study was undertaken to i...

    journal_title:Journal of medical virology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/jmv.20682

    authors: Thomas R,Macsween KF,McAulay K,Clutterbuck D,Anderson R,Reid S,Higgins CD,Swerdlow AJ,Harrison N,Williams H,Crawford DH

    更新日期:2006-09-01 00:00:00

  • Dengue RNA detection and seroprevalence in blood donors during an outbreak in the São Paulo State, Brazil, 2016.

    abstract::Most dengue virus (DENV) infections remain asymptomatic. This increases the risk of DENV transfusion transmission (TT-DENV) during outbreaks. We evaluated DENV viremia in 8475 blood donations assembled in minipools for the presence of DENV RNA. The tested samples were obtained between February and May, 2016, during a ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26619

    authors: Slavov SN,Santos EV,Hespanhol MR,Rodrigues ES,Haddad R,Ubiali EMA,Covas DT,Kashima S

    更新日期:2020-10-22 00:00:00

  • Human parechovirus infections in patients admitted to hospital in Northern Italy, 2008-2010.

    abstract::Human parechoviruses (HPeVs) infection is associated with a wide range of clinical syndromes such as respiratory, gastrointestinal, neurologic diseases, and neonatal sepsis-like illness. The main objective of this study was to investigate the epidemiology of HPeVs infection in hospitalized patients in a period of 2 ye...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23197

    authors: Piralla A,Furione M,Rovida F,Marchi A,Stronati M,Gerna G,Baldanti F

    更新日期:2012-04-01 00:00:00

  • Detection of viral antigens in cerebrospinal fluid of patients with herpes simplex virus encephalitis.

    abstract::Thirty-two cerebrospinal fluid (CSF) samples from eighteen patients with confirmed herpes simplex encephalitis (HSE) were assayed by an indirect enzyme-linked immunosorbent assay (ELISA) for the presence of viral antigens. The results are expressed as an antigen ratio distinguishing between herpes simplex virus (HSV) ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890210209

    authors: Bos CA,Olding-Stenkvist E,Wilterdink JB,Scheffer AJ

    更新日期:1987-02-01 00:00:00

  • Hemorrhagic fever with renal syndrome caused by Hantaan virus infection in four pregnant Chinese women.

    abstract::Hantavirus infection during pregnancy can influence both maternal and fetal outcomes. Here, we describe four cases of hemorrhagic fever with renal syndrome (HFRS) in pregnant Chinese women. The HFRS put these women at increased risk for severe illness, despite the patients' symptomologies in the onset phase were simil...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24856

    authors: Ji F,Zhao W,Liu H,Zheng H,Wang S,He C,Wang W,Zhang R,Bai D,Tian C,Zhao W,Deng H

    更新日期:2017-10-01 00:00:00

  • Genetic variability of hepatitis C virus non-structural protein 3 and virus-specific CD8+ response in patients with chronic hepatitis C.

    abstract::Hepatitis C virus (HCV) variation in specific T-cell epitopes may represent a mechanism of viral persistence in chronic infection. We examined the HCV non-structural protein 3 (NS3), including the immunologically relevant epitopes HCV NS3-2 KLVALGINAV (human leukocyte antigen [HLA]-A2-restricted) and HCV NS3-1391 LIFC...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20036

    authors: López-Labrador FX,He XS,Berenguer M,Cheung RC,González-Candelas F,Wright TL,Greenberg HB

    更新日期:2004-04-01 00:00:00

  • Hepatitis C virus genotype 4 in Southern and Central Spain does not originate from recent foreign migration waves.

    abstract::Hepatitis C virus genotype 4 (HCV-4) is highly prevalent in Spain, but the information on the molecular characterization of HCV-4 in this region is scarce. Due to this, the molecular characteristics and the evolution of HCV-4 infection in Seville were analyzed (Southern Spain) and compared them with samples from Madri...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23657

    authors: Di Lello FA,Neukam K,Parra-Sanchez M,Plaza Z,Soriano V,Cifuentes C,Mira JA,Poveda E,Pineda JA

    更新日期:2013-10-01 00:00:00

  • Junin virus-induced astrocytosis is impaired by iNOS inhibition.

    abstract::Because Junin virus (JV) experimental encephalitis of mice and rats is characterized by mild histopathological changes that do not seem to justify per se lethality after intracerebral infection, such a murine model seems adequate to investigate the potential role of inducible nitric oxide synthase (iNOS) as a pathogen...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10254

    authors: Gómez RM,Yep A,Schattner M,Berría MI

    更新日期:2003-01-01 00:00:00

  • Molecular characterization and phylogenetic analysis of human parainfluenza virus type 3 isolated from Saudi Arabia.

    abstract::Human parainfluenza virus 3 (HPIV-3) is a leading cause of respiratory disease in children worldwide. Previous sequence analyses of the entire virus genome, among different HPIV-3 strains, demonstrated that HN is the most variable gene. There is a dearth of data on HPIV-3 strains circulating in Saudi Arabia. In this r...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23326

    authors: Almajhdi FN,Alshaman MS,Amer HM

    更新日期:2012-08-01 00:00:00

  • Analysis of influenza A H3N2 strains isolated in England during 1995-1996 using polymerase chain reaction restriction.

    abstract::A polymerase chain reaction-restriction (PCR-restriction) endonuclease assay was developed to allow rapid analysis of influenza A H3N2 viruses circulating in England during 1995-1996. Restriction endonuclease digestion with two enzymes of amplicons derived from PCR of the HA1 portion of the influenza haemagglutinin (H...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:

    authors: Ellis JS,Sadler CJ,Laidler P,de Andrade HR,Zambon MC

    更新日期:1997-03-01 00:00:00

  • Outbreaks of hepatitis A in England and Wales associated with two co-circulating hepatitis A virus strains.

    abstract::During 2002, an upsurge in frequency of hepatitis A outbreaks among injecting drug users was observed in England and Wales. As lack of risk factor information and the high mobility of the cases made linkage of outbreaks difficult, the relationship of nucleotide sequences in the VP1/2PA junction of the hepatitis A viru...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21207

    authors: Ngui SL,Granerod J,Jewes LA,Crowcroft NS,Teo CG,2002 Hepatitis A Outbreaks Investigation Network.

    更新日期:2008-07-01 00:00:00

  • Emergence of uncommon HIV-1 non-B subtypes and circulating recombinant forms and trends in transmission of antiretroviral drug resistance in patients with primary infection during the 2013-2015 period in Marseille, Southeastern France.

    abstract::Primary HIV-1 infections (PHI) with non-B subtypes are increasing in developed countries while transmission of HIV-1 harboring antiretroviral resistance-associated mutations (RAMs) remains a concern. This study assessed non-B HIV-1 subtypes and RAMs prevalence among patients with PHI in university hospitals of Marseil...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25228

    authors: Tamalet C,Tissot-Dupont H,Motte A,Tourrès C,Dhiver C,Ravaux I,Poizot-Martin I,Dieng T,Tomei C,Bregigeon S,Zaegel-Faucher O,Laroche H,Aherfi S,Mokhtari S,Chaudet H,Ménard A,Brouqui P,Stein A,Colson P

    更新日期:2018-10-01 00:00:00

  • Seroprevalence of hepatitis A virus antibodies in Turkish and Moroccan children in Rotterdam.

    abstract::Seasonal fluctuations in hepatitis A have been observed in the Netherlands related to Turkish and Moroccan children after visiting their home countries. This study determined the prevalence and associated factors of hepatitis A virus (HAV) antibodies in Turkish and Moroccan children in Rotterdam. A random sample was t...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10576

    authors: Richardus JH,Vos D,Veldhuijzen IK,Groen J

    更新日期:2004-02-01 00:00:00

  • Immunity against the GBV-B hepatitis virus in tamarins can prevent productive infection following rechallenge and is long-lived.

    abstract::GB virus-B (GBV-B) is the virus most closely related to hepatitis C virus (HCV). Thus, we have used GBV-B infection of tamarins, which develop acute hepatitis following experimental infection, as a surrogate model to study protective immunity. As challenge virus, we first produced a GBV-B pool from an infected tamarin...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21013

    authors: Bukh J,Engle RE,Govindarajan S,Purcell RH

    更新日期:2008-01-01 00:00:00

  • The inhibition of enterovirus 71 induced apoptosis by Durvillaea antarctica through P53 and STAT1 signaling pathway.

    abstract::The infection of enterovirus 71 (EV71) resulted in hand, foot, and mouth disease and may lead to severe nervous system damage and even fatalities. There are no effective drugs to treat the EV71 virus and it is crucial to find novel drugs against it. Polysaccharide isolated from Durvillaea antarctica green algae has an...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26693

    authors: Xu T,Li Y,Wu HL,Chen H,Wu H,Guo M,Zhao M,Wang C,Lin T,Lin Z,Chen D,Xiang W,Zhu B

    更新日期:2020-11-24 00:00:00

  • Lineage analysis of human papillomavirus type 18 based on E6 region in cervical samples of Iranian women.

    abstract::Distinct human papillomavirus (HPV) 18 variants are thought to differ in oncogenic potential and geographic distribution. As such, understanding the regional variants of HPV 18 would be of great importance for evolutionary, epidemiological, and biological analysis. In this regard, the sequence variations of E6 gene we...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26283

    authors: Salavatiha Z,Shoja Z,Heydari N,Marashi SM,Younesi S,Nozarian Z,Jalilvand S

    更新日期:2020-07-09 00:00:00

  • Impact of comorbidities on patients with COVID-19: A large retrospective study in Zhejiang, China.

    abstract::Coronavirus disease 2019 (COVID-19) has become a serious public health problem worldwide. Here, we stratified COVID-19 patients based on their comorbidities to assess their risk of serious adverse outcomes. We collected 856 hospitalized cases diagnosed with COVID-19 from 17 January to 7 February 2020, in Zhejiang Prov...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26183

    authors: Ye C,Zhang S,Zhang X,Cai H,Gu J,Lian J,Lu Y,Jia H,Hu J,Jin C,Yu G,Zhang Y,Sheng J,Yang Y

    更新日期:2020-11-01 00:00:00

  • Heterogeneity in E2 region of GBV-C/hepatitis G virus and hepatitis C virus.

    abstract::GB virus C/hepatitis G virus (GBV-C/HGV) is related distantly to hepatitis C virus (HCV). HCV has a hypervariable region (HVR), and exists as quasispecies in vivo. Although GBV-C/HGV also has replaceable amino acids in the presumed antigenic region, the existence and fluctuation of population of heterogeneous virus ha...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:

    authors: Kato T,Mizokami M,Nakano T,Orito E,Ohba K,Kondo Y,Tanaka Y,Ueda R,Mukaide M,Fujita K,Yasuda K,Iino S

    更新日期:1998-06-01 00:00:00

  • Incidence and seasonality of respiratory viruses causing acute respiratory infections in the Northern United Arab Emirates.

    abstract:BACKGROUND:The data on the seasonality of respiratory viruses helps to ensure the optimal vaccination period and to monitor the possible outbreaks of variant type. OBJECTIVES:This study was designed to describe the molecular epidemiology and seasonality of acute respiratory infection (ARI)-related respiratory viruses ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25464

    authors: Jeon JH,Han M,Chang HE,Park SS,Lee JW,Ahn YJ,Hong DJ

    更新日期:2019-08-01 00:00:00

  • Acute changes in cardiac function by direct acting antiviral therapy for hepatitis C-infected patients with thalassemia.

    abstract:BACKGROUND:Patients with thalassemia may also have cardiac abnormalities due to congenital problems, anemia, and increased burden of iron in their myocardium. This study was designed to evaluate the effects of direct acting antiviral (DAA) therapy on the cardiac function of hepatitis C virus (HCV)-infected patients wit...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25314

    authors: Khosravi A,Karimi-Sari H,Abedi-Andani M,Behnava B,Namvar A,Anvar A,Alavian SM

    更新日期:2019-03-01 00:00:00

  • Frequency and genotype of human parvovirus B19 among Iranian patients infected with HIV.

    abstract::The human parvovirus B19 (B19) usually causes a subclinical infection in immunocompetent individuals. Whereas immunocompromised individuals such as patients infected with HIV are at risk of persistent anemia due to B19 infection. Only few studies have been carried out on distribution and molecular epidemiology of B19 ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24169

    authors: Azadmanesh K,Mohraz M,Kazemimanesh M,Aghakhani A,Foroughi M,Banifazl M,Eslamifar A,Ramezani A

    更新日期:2015-07-01 00:00:00