Abstract:
OBJECTIVE:To evaluate the association between a serotonin (5-HT) transporter gene polymorphism and migraines in Koreans. BACKGROUND:The 5-HT metabolism is believed to play an important part in the pathophysiology of migraines, and a polymorphism of the serotonin transporter (5-HTT) promoter region might influence 5-HTT expression and serotonin uptake. METHODS:This study compared 52 patients with migraine and 170 healthy control subjects in order to determine the association between a polymorphism of the 5-HTT gene-linked polymorphic region (5-HTTLPR) and migraine. Using PCR techniques, the products of the 484-base pair (bp) fragments were denoted as being short alleles (s) and those of 528 bp as being long (l). RESULTS:The genotype distribution of the healthy controls was s/s (56.5%), s/l (38.2%), and l/l (5.3%) and that of the patients with migraine was 65.4%, 30.8%, and 3.8%, respectively. No significant differences were noted in the genotype and allele frequencies of 5-HTTLPR between the patients with migraine and the control subjects. CONCLUSIONS:A 5-HTTLPR polymorphism does not appear to be involved in the genetic predisposition to migraines.
journal_name
Headachejournal_title
Headacheauthors
Kim WK,Kim HS,Kim WJ,Lee KY,Park H,Kim CH,Kim SJ,Choi YCdoi
10.1111/j.1526-4610.2005.05187.xkeywords:
subject
Has Abstractpub_date
2005-09-01 00:00:00pages
1056-60issue
8eissn
0017-8748issn
1526-4610pii
HED05187journal_volume
45pub_type
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