Lung cancer screening.

Abstract:

PURPOSE OF REVIEW:Advances in imaging technologies and biomarker research offer hope that the incidence and mortality of lung cancer can be reduced by screening similar to what have been achieved for cancer of the cervix, breast, and colon. RECENT FINDINGS:Spiral computed tomography with multitrack scanners and autofluorescence bronchoscopy offer unprecedented sensitivity to detect lung cancer even during the preinvasive stage. The high sensitivity of these tests, however, is associated with a low specificity. Better selection of individuals at highest risk of lung cancer using biomarkers in sputum, blood, or exhaled breath, as well as a better understanding of genetic susceptibility, may improve their positive predictive values, minimize unnecessary downstream investigations or treatment, as well as reduce screening costs. SUMMARY:Improvement in the performance of sputum, exhaled breath, or blood biomarkers holds promise as the first screening step to identify individuals at highest risk of lung cancer beyond what age and smoking could predict to select those who would obtain the most benefits from spiral computed tomography or autofluorescence bronchoscopy as localization tools.

journal_name

Curr Opin Pulm Med

authors

McWilliams A,Lam S

doi

10.1097/01.mcp.0000166592.10666.d1

keywords:

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

272-7

issue

4

eissn

1070-5287

issn

1531-6971

pii

00063198-200507000-00003

journal_volume

11

pub_type

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