Abstract:
:Malaria in pregnancy is associated with placental accumulation of Plasmodium falciparum-infected erythrocytes (IE) that adhere to chondroitin sulfate A (CSA). Adhesion is mediated by P. falciparum erythrocyte membrane protein 1 (PfEMP1), a variant parasite protein expressed on the surface of IE and encoded by var genes. Rabbit antiserum was generated against the CSA-adherent P. falciparum line CS2, in which the dominant var transcribed is var2csa, a relatively conserved var gene that has been associated with CSA adhesion. Anti-CS2 recognized genetically distinct CSA-adherent P. falciparum lines but not CD36-adherent parent lines. Reactivity with anti-CS2 correlated with the level of adhesion to CSA. Fluorescence-activated cell sorting according to binding of anti-CS2 showed reactivity was associated with CSA adhesion and transcription of var2csa. These data are consistent with the hypothesis that var2csa encodes a PfEMP1 expressed on the surface of IE, which mediates adhesion to CSA and is relatively conserved between genetically distinct strains of P. falciparum.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Elliott SR,Duffy MF,Byrne TJ,Beeson JG,Mann EJ,Wilson DW,Rogerson SJ,Brown GVdoi
10.1128/IAI.73.5.2848-2856.2005keywords:
subject
Has Abstractpub_date
2005-05-01 00:00:00pages
2848-56issue
5eissn
0019-9567issn
1098-5522pii
73/5/2848journal_volume
73pub_type
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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doi:10.1128/IAI.32.2.889-896.1981
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.8.3521-3527.1994
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.11.6.1407-1408.1975
更新日期:1975-06-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.1.398-406.1991
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journal_title:Infection and immunity
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:1975-03-01 00:00:00
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journal_title:Infection and immunity
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更新日期:1971-11-01 00:00:00
abstract::Bacillus anthracis, the etiological agent of anthrax disease, is a proven weapon of bioterrorism. Currently, the only licensed vaccine against anthrax in the United States is AVA Biothrax, which, although efficacious, suffers from several limitations. This vaccine requires six injectable doses over 18 months to stimul...
journal_title:Infection and immunity
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journal_title:Infection and immunity
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.1.41-47.1989
更新日期:1989-01-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.4.2762-2765.2001
更新日期:2001-04-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.35.1.229-239.1982
更新日期:1982-01-01 00:00:00
abstract::Neonatal piglets have been used as models to study human campylobacteriosis and helicobacteriosis. The purpose of this study was to determine the relative pathogenicities, on the basis of the duration of fecal shedding and colonization of tissues, of three Arcobacter species in 1-day-old cesarean-derived colostrum-dep...
journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:1996-06-01 00:00:00