Cross-reactive surface epitopes on chondroitin sulfate A-adherent Plasmodium falciparum-infected erythrocytes are associated with transcription of var2csa.

Abstract:

:Malaria in pregnancy is associated with placental accumulation of Plasmodium falciparum-infected erythrocytes (IE) that adhere to chondroitin sulfate A (CSA). Adhesion is mediated by P. falciparum erythrocyte membrane protein 1 (PfEMP1), a variant parasite protein expressed on the surface of IE and encoded by var genes. Rabbit antiserum was generated against the CSA-adherent P. falciparum line CS2, in which the dominant var transcribed is var2csa, a relatively conserved var gene that has been associated with CSA adhesion. Anti-CS2 recognized genetically distinct CSA-adherent P. falciparum lines but not CD36-adherent parent lines. Reactivity with anti-CS2 correlated with the level of adhesion to CSA. Fluorescence-activated cell sorting according to binding of anti-CS2 showed reactivity was associated with CSA adhesion and transcription of var2csa. These data are consistent with the hypothesis that var2csa encodes a PfEMP1 expressed on the surface of IE, which mediates adhesion to CSA and is relatively conserved between genetically distinct strains of P. falciparum.

journal_name

Infect Immun

journal_title

Infection and immunity

authors

Elliott SR,Duffy MF,Byrne TJ,Beeson JG,Mann EJ,Wilson DW,Rogerson SJ,Brown GV

doi

10.1128/IAI.73.5.2848-2856.2005

keywords:

subject

Has Abstract

pub_date

2005-05-01 00:00:00

pages

2848-56

issue

5

eissn

0019-9567

issn

1098-5522

pii

73/5/2848

journal_volume

73

pub_type

杂志文章
  • Role of Nramp1 deletion in Chlamydia infection in mice.

    abstract::Elicited macrophages from 129sv mice with a functional deletion of the natural-resistance-associated macrophage protein 1 gene (Nramp1) were shown to be as susceptible as wild-type mice to infection with the Chlamydia trachomatis mouse pneumonitis and L3 serovars and to Chlamydia pneumoniae. Furthermore, the two group...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/iai.68.8.4831-4833.2000

    authors: Pal S,Peterson EM,de La Maza LM

    更新日期:2000-08-01 00:00:00

  • Replication of vesicular stomatitis virus in murine spleen cells: enrichment of the virus-replicating lymphocytes and analysis of replication restriction.

    abstract::Vesicular stomatitis virus (Indiana strain) will only grow in T lymphocytes which have been stimulated to undergo cell division. Evidence is presented that a considerable enrichment of the vesicular stomatitis virus-replicating T cells may be accomplished in the mouse spleen by passing the spleen cells over glass wool...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.32.1.169-172.1981

    authors: Webb DR,Munshi S,Banerjee AK

    更新日期:1981-04-01 00:00:00

  • Protection against experimental Bordetella bronchiseptica infection in mice by active immunization with killed vaccine.

    abstract::Mice immunized with a killed vaccine of phase I Bordetella bronchiseptica were challenged with various numbers of virulent B. bronchiseptica by intraperitoneal, intracerebral, or intranasal routes. The course of infection was compared among these routes, and the protective effect of vaccination was quantitatively anal...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.41.2.598-603.1983

    authors: Sekiya K,Kawahira M,Nakase Y

    更新日期:1983-08-01 00:00:00

  • Comparison of techniques for primary isolation of respiratory Mycoplasma pulmonis from rats.

    abstract::Studies were performed to determine the optimal sites for primary isolation of Mycoplasma pulmonis from the respiratory system of laboratory rats. In a preliminary study, a group of 42 rats was cultured for respiratory M. pulmonis at several sites. Tracheal washes yielded the highest number of positive cultures (61.9%...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.26.2.590-593.1979

    authors: Lentsch RH,Wagner JE,Owens DR

    更新日期:1979-11-01 00:00:00

  • Effects of cell source, mouse strain, and immunosuppressive treatment on production of virulent and attenuated murine cytomegalovirus.

    abstract::Murine cytomegalovirus pools from various in vitro and in vivo sources were compared for virulence in suckling mice in an effort to identify the conditions which were necessary for the production of virulent and attenuated viruses. Virus passaged in tracheal ring and salivary gland organ cultures, where virus is produ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.33.3.840-847.1981

    authors: Selgrade MK,Nedrud JG,Collier AM,Gardner DE

    更新日期:1981-09-01 00:00:00

  • Comparable endotoxic properties of lipopolysaccharides are manifest in diverse clinical isolates of gram-negative bacteria.

    abstract::In general there is a poor correlation between serum lipopolysaccharide (LPS; the biologically active constituent of endotoxin) levels and mortality in septic patients. The objective of this study was to determine if chemical, structural, or biological differences among LPS from different clinical isolates of gram-neg...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/iai.68.4.1899-1904.2000

    authors: Luchi M,Morrison DC

    更新日期:2000-04-01 00:00:00

  • Involvement of Lsp, a member of the LraI-lipoprotein family in Streptococcus pyogenes, in eukaryotic cell adhesion and internalization.

    abstract::Three open reading frames (ORFs) were identified by a genome walking strategy in the genomes of serotype M49 group A streptococcal (GAS) strains CS101 and 591. These ORFs were located between the mga core regulon and the dipeptide permease operon. The deduced amino acid (aa) sequences contained signature sequences ind...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/iai.70.9.4859-4869.2002

    authors: Elsner A,Kreikemeyer B,Braun-Kiewnick A,Spellerberg B,Buttaro BA,Podbielski A

    更新日期:2002-09-01 00:00:00

  • Inhibition of phagolysosome fusion is localized to Chlamydia psittaci-laden vacuoles.

    abstract::Intracellular survival of Chlamydia psittaci is in part dependent on the ability of the organism to thwart phagolysosome formation. Circumvention of phagolysosome fusion could be either localized to chlamydia-laden vacuoles or generalized to all phagosomes in the host cell. To determine which of these modes is in oper...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.32.2.889-896.1981

    authors: Eissenberg LG,Wyrick PB

    更新日期:1981-05-01 00:00:00

  • Human antibodies against Plasmodium falciparum liver-stage antigen 3 cross-react with Plasmodium yoelii preerythrocytic-stage epitopes and inhibit sporozoite invasion in vitro and in vivo.

    abstract::The Plasmodium falciparum liver-stage antigen 3 (LSA3), a recently identified preerythrocytic antigen, induces protection against malaria in chimpanzees. Using antibodies from individuals with hyperimmunity to malaria affinity purified on recombinant or synthetic polypeptides of LSA3, we identified four non-cross-reac...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.69.6.3845-3952.2001

    authors: Brahimi K,Badell E,Sauzet JP,BenMohamed L,Daubersies P,Guérin-Marchand C,Snounou G,Druilhe P

    更新日期:2001-06-01 00:00:00

  • Opacity-associated adhesin repertoire in hyperinvasive Neisseria meningitidis.

    abstract::The opacity (Opa) proteins mediate a variety of interactions between the bacterium Neisseria meningitidis and its human host. These interactions are thought to be of central importance in both the asymptomatic colonization of the nasopharynx and the sporadic occurrence of meningococcal disease. The receptor specificit...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.00293-06

    authors: Callaghan MJ,Jolley KA,Maiden MC

    更新日期:2006-09-01 00:00:00

  • Interleukin-6 production by human monocytes stimulated with Cryptococcus neoformans components.

    abstract::In order to ascertain if Cryptococcus neoformans components can induce interleukin-6 (IL-6) production, we stimulated human whole blood with purified capsular products. Their potencies in stimulating IL-6 release were mannoproteins > galactoxylomannan = glucuronoxylomannan > alpha(1-3)glucan. IL-6 production was tumor...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.65.6.2454-2456.1997

    authors: Delfino D,Cianci L,Lupis E,Celeste A,Petrelli ML,Curró F,Cusumano V,Teti G

    更新日期:1997-06-01 00:00:00

  • The type III secretion effector NleF of enteropathogenic Escherichia coli activates NF-κB early during infection.

    abstract::The enteric pathogens enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli employ a type 3 secretion system (T3SS) to manipulate the host inflammatory response during infection. Previously, it has been reported that EPEC, in a T3SS-dependent manner, induces an early proinflammatory response through a...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.02131-14

    authors: Pallett MA,Berger CN,Pearson JS,Hartland EL,Frankel G

    更新日期:2014-11-01 00:00:00

  • Genetic stability of Borrelia burgdorferi recovered from chronically infected immunocompetent mice.

    abstract::Persistent infection with Borrelia burgdorferi in the presence of a vigorous host immune response has been demonstrated in humans and in animal models of Lyme disease. Long-term persistence of B. burgdorferi was documented recently in our studies of BALB/c and C3H mice infected with cloned and uncloned strains of B. b...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.62.8.3521-3527.1994

    authors: Persing DH,Mathiesen D,Podzorski D,Barthold SW

    更新日期:1994-08-01 00:00:00

  • GNA33 of Neisseria meningitidis is a lipoprotein required for cell separation, membrane architecture, and virulence.

    abstract::GNA33 is a membrane-bound lipoprotein with murein hydrolase activity that is present in all Neisseria species and well conserved in different meningococcal isolates. The protein shows 33% identity to a lytic transglycolase (MltA) from Escherichia coli and has been shown to be involved in the degradation of both insolu...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/iai.72.4.1914-1919.2004

    authors: Adu-Bobie J,Lupetti P,Brunelli B,Granoff D,Norais N,Ferrari G,Grandi G,Rappuoli R,Pizza M

    更新日期:2004-04-01 00:00:00

  • Occurrence of severe destructive lyme arthritis in hamsters vaccinated with outer surface protein A and challenged with Borrelia burgdorferi.

    abstract::Arthritis is a frequent and major complication of infection with Borrelia burgdorferi sensu stricto. The antigens responsible for the induction of arthritis are unknown. Here we provide direct evidence that a major surface protein, outer surface protein A (OspA), can induce arthritis. Hamsters were vaccinated with 30,...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/iai.68.2.658-663.2000

    authors: Croke CL,Munson EL,Lovrich SD,Christopherson JA,Remington MC,England DM,Callister SM,Schell RF

    更新日期:2000-02-01 00:00:00

  • L-arginine elution of measles virus adsorbed on monkey erythrocytes.

    abstract::l-Arginine (1 M) eluted measles virus adsorbed on monkey erythrocytes without affecting the infectious and hemagglutinating activities of the virus. This phenomenon was also observed for encephalomyocarditis virus and Newcastle disease virus. ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.11.6.1407-1408.1975

    authors: Lebon P,Protat A,Moline P

    更新日期:1975-06-01 00:00:00

  • Prostaglandin E release from human monocytes treated with lipopolysaccharides isolated from Bacteroides intermedius and Salmonella typhimurium: potentiation by gamma interferon.

    abstract::The purpose of this investigation was to examine gamma interferon potentiation of lipopolysaccharide (LPS) responses in human monocytes by using phenol-water-extracted (unfractionated) and highly purified LPS preparations isolated from Bacteroides intermedius and Salmonella typhimurium. Phenol-water-extracted LPS prep...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.59.1.398-406.1991

    authors: Nichols FC,Peluso JF,Tempro PJ,Garrison SW,Payne JB

    更新日期:1991-01-01 00:00:00

  • Ehrlichia canis gp200 contains dominant species-specific antibody epitopes in terminal acidic domains.

    abstract::Species-specific antibody epitopes within several major immunoreactive protein orthologs of Ehrlichia species have recently been identified and molecularly characterized. In this study, dominant B-cell epitopes within the acidic (pI 5.35) ankyrin repeat-containing 200-kDa major immunoreactive protein (gp200) of Ehrlic...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.00041-07

    authors: Nethery KA,Doyle CK,Zhang X,McBride JW

    更新日期:2007-10-01 00:00:00

  • Sequencing of the gene encoding the major pilin of pilus colonization factor antigen III (CFA/III) of human enterotoxigenic Escherichia coli and evidence that CFA/III is related to type IV pili.

    abstract::The plasmid-encoded structural gene cofA necessary for the production of the major pilin subunit of pilus colonization factor antigen III (CFA/III) of human enterotoxigenic Escherichia coli was identified, and the nucleotide sequence of the gene was determined. cofA consists of 714 nucleotides encoding a 238-amino-aci...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.63.2.724-728.1995

    authors: Taniguchi T,Fujino Y,Yamamoto K,Miwatani T,Honda T

    更新日期:1995-02-01 00:00:00

  • Unexpected Role of CD8 T Cells in Accelerated Clearance of Salmonella enterica Serovar Typhimurium from H-2 Congenic mice.

    abstract::Salmonella infection can cause gastroenteritis in healthy individuals or a serious, systemic infection in immunocompromised patients and has a global impact. CD4 Th1 cells represent the main lymphocyte population that participates in bacterial clearance during both primary and secondary infections in mice of the H-2b ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.00588-19

    authors: Labuda JC,Depew CE,Pham OH,Benoun JM,Ramirez NA,McSorley SJ

    更新日期:2019-10-18 00:00:00

  • Fine specificity of the genetically controlled immune response to native and recombinant gp15/400 (polyprotein allergen) of Brugia malayi.

    abstract::Polyprotein allergens are a family of structurally homologous molecules from parasitic nematodes which induce specific immunoglobulin E in infected individuals. We show here that both H-2 and non-H-2 factors determine the ability of mice to generate T- and B-cell responses to the filarial polyprotein allergen (Brugia ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.63.8.2892-2898.1995

    authors: Allen JE,Lawrence RA,Maizels RM

    更新日期:1995-08-01 00:00:00

  • Deletion of wboA enhances activation of the lectin pathway of complement in Brucella abortus and Brucella melitensis.

    abstract::Brucella spp. are gram-negative intracellular pathogens that survive and multiply within phagocytic cells of their hosts. Smooth organisms present O polysaccharides (OPS) on their surface. These OPS help the bacteria avoid the bactericidal action of serum. The wboA gene, coding for the enzyme glycosyltransferase, is e...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.69.7.4407-4416.2001

    authors: Fernandez-Prada CM,Nikolich M,Vemulapalli R,Sriranganathan N,Boyle SM,Schurig GG,Hadfield TL,Hoover DL

    更新日期:2001-07-01 00:00:00

  • Immunosuppression by hydroxystilbamidine isethionate, a lysosome-stabilizing, anti-proteolytic, antifungal drug.

    abstract::Hydroxystilbamidine (HSB) is a potent suppressor of the plaque-forming cell response of mice injected with heterologous erythrocytes. HSB, given in varying doses and injection schedules, suppressed both the primary and secondary immune responses to bovine serum albumin. Apparently the effect is not simply a toxic effe...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.11.3.441-444.1975

    authors: Folds JD,Orlando G,Spitznagel JK

    更新日期:1975-03-01 00:00:00

  • Type-specific antigens of group B type Ic streptococci.

    abstract::The type-specific antigens of group B type Ic (old designation type Ii) streptococci were extracted, purified, and characterized by serological and chemical methods. The Ia antigen, shared by types Ia and Ic, is a polysaccharide composed of 69% galactose and 25% glucosamine (i.e., 31% N-acetyl-glucosamine). However, t...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.4.5.596-604.1971

    authors: Wilkinson HW,Eagon RG

    更新日期:1971-11-01 00:00:00

  • Anthrax protective antigen delivered by Salmonella enterica serovar Typhi Ty21a protects mice from a lethal anthrax spore challenge.

    abstract::Bacillus anthracis, the etiological agent of anthrax disease, is a proven weapon of bioterrorism. Currently, the only licensed vaccine against anthrax in the United States is AVA Biothrax, which, although efficacious, suffers from several limitations. This vaccine requires six injectable doses over 18 months to stimul...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.00828-08

    authors: Osorio M,Wu Y,Singh S,Merkel TJ,Bhattacharyya S,Blake MS,Kopecko DJ

    更新日期:2009-04-01 00:00:00

  • Characterization of the CpxRA regulon in Haemophilus ducreyi.

    abstract::The Haemophilus ducreyi 35000HP genome encodes a homolog of the CpxRA two-component cell envelope stress response system originally characterized in Escherichia coli. CpxR, the cytoplasmic response regulator, was shown previously to be involved in repression of the expression of the lspB-lspA2 operon (M. Labandeira-Re...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.00678-10

    authors: Labandeira-Rey M,Brautigam CA,Hansen EJ

    更新日期:2010-11-01 00:00:00

  • Demonstration of antigen-specific T cells and histopathological alterations in mice experimentally inoculated with Borrelia burgdorferi.

    abstract::Antigen-specific T-cell responses and histopathological changes were studied in mice experimentally inoculated with Borrelia burgdorferi B31. Inbred mice with different H-2 haplotypes and/or different genetic backgrounds were inoculated with B. burgdorferi organisms and tested for antigen-specific T-cell responses in ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.57.1.41-47.1989

    authors: Schaible UE,Kramer MD,Justus CW,Museteanu C,Simon MM

    更新日期:1989-01-01 00:00:00

  • Saccharomyces boulardii stimulates intestinal immunoglobulin A immune response to Clostridium difficile toxin A in mice.

    abstract::Saccharomyces boulardii is a nonpathogenic yeast that protects against antibiotic-associated diarrhea and recurrent Clostridium difficile colitis. The administration of C. difficile toxoid A by gavage to S. boulardii-fed BALB/c mice caused a 1.8-fold increase in total small intestinal immunoglobulin A levels (P = 0.00...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.69.4.2762-2765.2001

    authors: Qamar A,Aboudola S,Warny M,Michetti P,Pothoulakis C,LaMont JT,Kelly CP

    更新日期:2001-04-01 00:00:00

  • Serology of Neisseria gonorrhoeae: W-antigen serogrouping by coagglutination and protein I serotyping by enzyme-linked immunosorbent assay both detect protein I antigens.

    abstract::A total of 224 strains were serogrouped by coagglutination (COA) and serotyped by protein I enzyme-linked immunosorbent assay (ELISA). Of these strains, 61 were from patients with disseminated gonococcal infection, 21 were from patients with pelvic inflammatory disease, and 115 were from patients with uncomplicated go...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.35.1.229-239.1982

    authors: Sandstrom EG,Knapp JS,Buchanan TB

    更新日期:1982-01-01 00:00:00

  • Infection of cesarean-derived colostrum-deprived 1-day-old piglets with Arcobacter butzleri, Arcobacter cryaerophilus, and Arcobacter skirrowii.

    abstract::Neonatal piglets have been used as models to study human campylobacteriosis and helicobacteriosis. The purpose of this study was to determine the relative pathogenicities, on the basis of the duration of fecal shedding and colonization of tissues, of three Arcobacter species in 1-day-old cesarean-derived colostrum-dep...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.64.6.2295-2299.1996

    authors: Wesley IV,Baetz AL,Larson DJ

    更新日期:1996-06-01 00:00:00