Abstract：
BACKGROUND:Interleukin (IL)-18 regulates the expression of the proinflammatory cytokine interferon (IFN)-gamma. The present study sought to test the putative involvement of six different IL-18 gene polymorphisms in pre-disposition to destructive periodontal disease. METHODS:A total of 123 patients with periodontitis and 121 healthy controls were genotyped for six IL-18 polymorphisms at position -656, -607, -137, +113, +127 and codon 35/3. Genotyping has been performed by PCR and restriction fragment length polymorphism analysis. The frequencies of alleles and genotypes as well of haplotypes within both study groups were compared using the Pearson Chi-square test at a level of significance of 5% (p<0.05). RESULTS:Coseggregation was found to be 100% for the two polymorphisms at position -656 and -607 as well as for the polymorphisms at position -137, +113, and +127. The distribution of genotypes for the IL-18 gene polymorphism at position -656/-607 (p=0.854), at position -137/+113/+127 (p=0.320), and at codon 35/3 (p=0.481) was not significantly different among periodontitis patients if compared with healthy control subjects. The distribution of haplotype combinations for the -607 and -137 polymorphism also showed not significant difference between the both study groups (p=0.545). CONCLUSION:Herein the six different IL-18 gene polymorphisms were not associated with destructive periodontal disease.
journal_name
J Clin Periodontoljournal_title
Journal of clinical periodontologyauthors
Folwaczny M,Glas J,Török HP,Tonenchi L,Paschos E,Bauer B,Limbersky O,Folwaczny Cdoi
10.1111/j.1600-051X.2005.00711.xkeywords:
subject
Has Abstractpub_date
2005-05-01 00:00:00pages
530-4issue
5eissn
0303-6979issn
1600-051Xpii
CPE711journal_volume
32pub_type
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journal_title：Journal of clinical periodontology
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更新日期：2005-06-01 00:00:00
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journal_title：Journal of clinical periodontology
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doi：10.1111/j.1600-051x.1993.tb01752.x
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doi：10.1111/jcpe.12393
更新日期：2015-05-01 00:00:00
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journal_title：Journal of clinical periodontology
pub_type： 杂志文章,评审
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journal_title：Journal of clinical periodontology
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pub_type： 杂志文章,随机对照试验
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更新日期：2010-02-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1111/j.1600-051X.2011.01834.x
更新日期：2012-02-01 00:00:00
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doi：10.1111/j.1600-051x.1997.tb00217.x
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abstract：:Periodontal disease indicators were evaluated according to the periodontal treatment need system (PTNS) in random samples of 35-year-old citizens of Oslo in 1973 and 1984. The study indicated that although periodontal disease was a common finding in both samples, there was a significant reduction in score C (indicatin...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1990.tb00021.x
更新日期：1990-04-01 00:00:00
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journal_title：Journal of clinical periodontology
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doi：10.1111/jcpe.12656
更新日期：2017-03-01 00:00:00
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journal_title：Journal of clinical periodontology
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更新日期：2009-10-01 00:00:00
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journal_title：Journal of clinical periodontology
pub_type： 杂志文章
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更新日期：2018-01-01 00:00:00
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journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1980.tb02158.x
更新日期：1980-12-01 00:00:00
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journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1991.tb01133.x
更新日期：1991-03-01 00:00:00
abstract：:Previous research has shown that probing force and probe tine shape influence the clinically assessed probing depth. The purpose of the present study was to investigate the effect of tine shape and probing force on probe penetration, in relation to the microscopically assessed attachment level in untreated periodontal...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1998.tb02465.x
更新日期：1998-05-01 00:00:00
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更新日期：2017-11-01 00:00:00
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doi：
更新日期：1990-10-01 00:00:00
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journal_title：Journal of clinical periodontology
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doi：10.1111/jcpe.12235
更新日期：2014-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：2017-04-01 00:00:00
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journal_title：Journal of clinical periodontology
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doi：10.1111/j.1600-051X.2009.01465.x
更新日期：2009-11-01 00:00:00
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更新日期：2016-01-01 00:00:00
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journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1034/j.1600-051x.2000.027003149.x
更新日期：2000-03-01 00:00:00
abstract：:Dehiscence depths were measured in vivo during surgical treatment of 113 teeth with gingival recession in 27 subjects. The average dehiscence depth determined was 5.43 mm with an average recession depth of 2.67 mm. Statistical evidence of a correlation between recession depth and dehiscence depth (average distance bet...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051x.1984.tb00911.x
更新日期：1984-10-01 00:00:00
abstract：BACKGROUND:Peri-implant soft tissue may be critical to prevent inflammation and promote gingival margin stability. The purpose of this randomized clinical trial (RCT) is to compare xenogeneic collagen matrix (XCM) versus connective tissue graft (CTG) to increase buccal soft tissue thickness at implant site. MATERIALS ...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章,随机对照试验
doi：10.1111/jcpe.12750
更新日期：2017-07-01 00:00:00
abstract：OBJECTIVES:Although the direct cause for periodontitis is oral bacterial infection, its progression depends upon genetic and environmental factors. Smoking, one of the environmental factors, is a risk factor for the development and severity of periodontitis. Therefore, individual susceptibility to periodontitis may be ...
journal_title：Journal of clinical periodontology
pub_type： 杂志文章
doi：10.1111/j.1600-051X.2004.00587.x
更新日期：2004-11-01 00:00:00
