Changes of ECM and CAM gene expression profile in the cirrhotic liver after HCV infection: analysis by cDNA expression array.

Abstract:

AIM:We aimed to observe the expression of extracellular matrix (ECM) and cellular adhesion molecules (CAM) in cirrhotic liver tissues after hepatitis C virus (HCV) infection. METHODS:Twelve patients with post HCV inflammatory liver cirrhosis were selected to evaluate their liver function and other virological, pathological parameters. Then three specimens of cirrhotic patients whose health assessment results and laboratory data were similar and three normal liver specimens explanted from liver grafts prepared for liver transplantation were chosen for investigating gene expression of ECM and CAM using cDNA expression array. RESULTS:The cDNA array assay revealed 36.7% (36/96) of genes with changes, in which 26.3% (26/96) was up-regulated and 10.1% (10/96) was down-regulated. Integrin (ITGA), collagen (COL), ADAMTS were identified as the characteristic changes of ECM and CAM gene expression levels. ITGA were demonstrated beta1 and beta2 sub-section changed in liver cirrhosis. CONCLUSION:ECM and CAM play an important role in the progression of liver cirrhosis after HCV infection. The capital mechanism is related to the inflammatory cells infiltration, the activation and transformation of ECM producing cells and the imbalance between production and elimination of ECM.

journal_name

World J Gastroenterol

authors

Xu X,Li YM,Ji H,Hou CZ,Cheng YB,Ma FP

doi

10.3748/wjg.v11.i14.2184

keywords:

subject

Has Abstract

pub_date

2005-04-14 00:00:00

pages

2184-7

issue

14

eissn

1007-9327

issn

2219-2840

journal_volume

11

pub_type

杂志文章
  • Failure of interferon-γ pre-treated mesenchymal stem cell treatment in a patient with Crohn's disease.

    abstract::Mesenchymal stem cells (MSC) are cells of stromal origin which exhibit unlimited self-renewal capacity and pluripotency in vitro. It has recently been observed that MSC may also exert a profound immunosuppressive and anti-inflammatory effect both in vitro and in vivo with consequent potential use in autoimmune disorde...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i14.4379

    authors: Taddio A,Tommasini A,Valencic E,Biagi E,Decorti G,De Iudicibus S,Cuzzoni E,Gaipa G,Badolato R,Prandini A,Biondi A,Ventura A

    更新日期:2015-04-14 00:00:00

  • Molecular markers (PECAM-1, ICAM-3, HLA-DR) determine prognosis in primary non-Hodgkin's gastric lymphoma patients.

    abstract:AIM:To investigate the prognostic significance of PECAM-1, ICAM-3 and HLA-DR antigens in patients with primary non-Hodgkin's gastric lymphoma. METHODS:We immunohistochemically studied PECAM-1, ICAM-3 and HLA-DR antigen expression in 36 B-cell MALT-type primary gastric lymphoma patients. Ten non-malignant and ten healt...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i12.1924

    authors: Darom A,Gomatos IP,Leandros E,Chatzigianni E,Panousopoulos D,Konstadoulakis MM,Androulakis G

    更新日期:2006-03-28 00:00:00

  • Relationships of CDXs and apical sodium-dependent bile acid transporter in Barrett's esophagus.

    abstract::Barrett's esophagus (BE) is characterized by intestinal metaplasia with the differentiated epithelium replaced by another type of epithelium morphologically similar to normal intestinal epithelium. The metaplasia is preceded by bile and acid reflux into the esophagus. BE is a premalignant condition associated with inc...

    journal_title:World journal of gastroenterology

    pub_type: 评论,杂志文章

    doi:10.3748/wjg.v19.i18.2736

    authors: Zhao J,Gregersen H

    更新日期:2013-05-14 00:00:00

  • Noninvasive assessment of liver fibrosis in patients with chronic hepatitis B.

    abstract::Infection with hepatitis B virus is an important health problem worldwide: it affects more than 350 million people and is a leading cause of liver-related morbidity, accounting for 1 million deaths annually. Hepatic fibrosis is a consequence of the accumulation of extracellular matrix components in the liver. An accur...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i34.12031

    authors: Enomoto M,Morikawa H,Tamori A,Kawada N

    更新日期:2014-09-14 00:00:00

  • Proinflammatory effects and molecular mechanisms of interleukin-17 in intestinal epithelial cell line HT-29.

    abstract:AIM:To evaluate the proinflammatory effects and molecular mechanisms of interleukin (IL)-17 in intestinal epithelial cell line HT-29. METHODS:HT-29 cells were cultured with IL-17, tumor necrosis factor (TNF)-α, or the combination of both IL-17 and TNF-α. Real-time PCR and Western blot were used to measure the gene exp...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i47.17924

    authors: Wang YL,Fang M,Wang XM,Liu WY,Zheng YJ,Wu XB,Tao R

    更新日期:2014-12-21 00:00:00

  • Disrupted NF- kappa B activation after partial hepatectomy does not impair hepatocyte proliferation in rats.

    abstract:AIM:To analyze the effects of NF- kappa B inhibition by antioxidant pyrrolidine dithiocarbamate (PDTC) or TNF inhibitor pentoxifylline (PTX) on liver regeneration after partial hepatectomy (PH). METHODS:Saline, PDTC or PTX were injected 1 h before PH and rats were killed at 0.5 and 24 h after PH. Several control group...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i46.7345

    authors: Laurent S,Horsmans Y,Stärkel P,Leclercq I,Sempoux C,Lambotte L

    更新日期:2005-12-14 00:00:00

  • Anterior vs conventional approach hepatectomy for large liver cancer: a meta-analysis.

    abstract:AIM:To evaluate the clinical outcomes and safety of anterior- and conventional-approach hepatectomy for patients with large liver tumors. METHODS:PubMed, EMBASE, Google Scholar and the Cochrane Library databases were searched for randomized controlled trials (RCTs) and controlled clinical trials comparing anterior-app...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.3748/wjg.v20.i45.17235

    authors: Li L,Wang HQ,Wang Q,Yang J,Yang JY

    更新日期:2014-12-07 00:00:00

  • Patatin-like phospholipase domain containing-3 gene I148M polymorphism, steatosis, and liver damage in hereditary hemochromatosis.

    abstract:AIM:To investigate whether the patatin-like phospholipase domain containing-3 gene (PNPLA3) I148M polymorphism is associated with steatosis, fibrosis stage, and cirrhosis in hereditary hemochromatosis (HH). METHODS:We studied 174 consecutive unrelated homozygous for the C282Y HFE mutation of HH (C282Y+/+ HH) patients ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v18.i22.2813

    authors: Valenti L,Maggioni P,Piperno A,Rametta R,Pelucchi S,Mariani R,Dongiovanni P,Fracanzani AL,Fargion S

    更新日期:2012-06-14 00:00:00

  • Little girl who conquered the "ALPPS''.

    abstract::An insufficient future liver remnant (FLR) is associated with post-hepatectomy liver failure. Associating liver partition and portal vein ligation for stage hepatectomy (ALPPS) has been shown to be effective for the induction of rapid FLR hypertrophy so as to improve the resectability in patients with insufficient FLR...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i29.10208

    authors: Chan A,Chung PH,Poon RT

    更新日期:2014-08-07 00:00:00

  • MicroRNA-185-5p mediates regulation of SREBP2 expression by hepatitis C virus core protein.

    abstract:AIM:To investigate the molecular mechanism for regulation of cholesterol metabolism by hepatitis C virus (HCV) core protein in HepG2 cells. METHODS:HCV genotype 1b core protein was cloned and expressed in HepG2 cells. The cholesterol content was determined after transfection. The expression of sterol regulatory elemen...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i15.4517

    authors: Li M,Wang Q,Liu SA,Zhang JQ,Ju W,Quan M,Feng SH,Dong JL,Gao P,Cheng J

    更新日期:2015-04-21 00:00:00

  • Endoscopic diagnosis of Barrett's esophagus.

    abstract::The Prague C and M Criteria have been developed for the objective endoscopic diagnosis of Barrett's esophagus (BE). BE arises between the squamocolumnar junction and the gastroesophageal junction at the proximal margin of the gastric folds. In this study, we reported that 43.0% of the subjects examined were diagnosed ...

    journal_title:World journal of gastroenterology

    pub_type: 信件

    doi:10.3748/wjg.v18.i26.3477

    authors: Akiyama T,Sekino Y,Iida H,Koyama S,Gotoh E,Maeda S,Nakajima A,Inamori M

    更新日期:2012-07-14 00:00:00

  • Non-alcoholic fatty liver disease and type 2 diabetes mellitus: the liver disease of our age?

    abstract::Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease that might affect up to one-third of the adult population in industrialised countries. NAFLD incorporates histologically and clinically different non-alcoholic entities; fatty liver (NAFL, steatosis hepatis) and steatohepatitis (NASH-characterised by...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v20.i27.9072

    authors: Firneisz G

    更新日期:2014-07-21 00:00:00

  • Hepatitis C virus infection and health-related quality of life.

    abstract::Hepatitis C virus (HCV) hepatitis and other diseases related to HCV, such as cryoglobulinemia, lymphoma and renal failure, impair health-related quality of life (HRQoL). In addition, HCV per se might directly influence HRQoL via colonization of microglia in the brain or, indirectly, via the effect of systemic inflamma...

    journal_title:World journal of gastroenterology

    pub_type: 社论

    doi:10.3748/wjg.v18.i19.2295

    authors: Amodio P,Salari L,Montagnese S,Schiff S,Neri D,Bianco T,Minazzato L

    更新日期:2012-05-21 00:00:00

  • Endoscopic ultrasound-guided biliary drainage: Bilateral systems drainage via left duct approach.

    abstract::Endoscopic ultrasound (EUS)-guided biliary drainage is accepted as a less invasive, alternative treatment for patients in whom endoscopic retrograde cholangiopancreatography has failed. Most patients with malignant hilar obstruction undergo EUS-guided hepaticogastrostomy. The authors present the case of a 77-year-old ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i34.10045

    authors: Prachayakul V,Aswakul P

    更新日期:2015-09-14 00:00:00

  • Group II p21-activated kinases as therapeutic targets in gastrointestinal cancer.

    abstract::P21-activated kinases (PAKs) are central players in various oncogenic signaling pathways. The six PAK family members are classified into group I (PAK1-3) and group II (PAK4-6). Focus is currently shifting from group I PAKs to group II PAKs. Group II PAKs play important roles in many fundamental cellular processes, som...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v22.i3.1224

    authors: Shao YG,Ning K,Li F

    更新日期:2016-01-21 00:00:00

  • Successful esophagectomy in a patient with combined esophageal cancer and hemophilia B.

    abstract::Patients with esophageal cancer often require esophagectomy with esophagogastrostomy. However, the incidence of complications, such as hemorrhage, during operations for esophageal cancer is high, even with minimally invasive surgery. Without the appropriate interventions, the risk of major intraoperative and postopera...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i35.12701

    authors: Zhang GF,Chai Y,Li WS,Huang LS,Shen G

    更新日期:2014-09-21 00:00:00

  • Primary biliary cirrhosis-associated hepatocellular carcinoma in Chinese patients: incidence and risk factors.

    abstract:AIM:To investigate the incidence, characteristics, and risk factors for hepatocellular carcinoma (HCC) in Chinese patients with primary biliary cirrhosis (PBC). METHODS:We reviewed the data of 52 PBC-associated HCC patients treated at Beijing 302 Hospital from January 2002 to December 2013 and analyzed its incidence a...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i12.3554

    authors: Zhang XX,Wang LF,Jin L,Li YY,Hao SL,Shi YC,Zeng QL,Li ZW,Zhang Z,Lau GK,Wang FS

    更新日期:2015-03-28 00:00:00

  • Esophageal intramural pseudodiverticulosis of the residual esophagus after esophagectomy for esophageal cancer.

    abstract::A 91-year-old man was referred to our hospital with intermittent dysphagia. He had undergone esophagectomy for esophageal cancer (T3N2M0 Stage III) 11 years earlier. Endoscopic examination revealed an anastomotic stricture; signs of inflammation, including redness, erosion, edema, bleeding, friability, and exudate wit...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v21.i30.9223

    authors: Takeshita N,Kanda N,Fukunaga T,Kimura M,Sugamoto Y,Tasaki K,Uesato M,Sazuka T,Maruyama T,Aida N,Tamachi T,Hosokawa T,Asai Y,Matsubara H

    更新日期:2015-08-14 00:00:00

  • Association of core promoter mutations of hepatitis B virus and viral load is different in HBeAg(+) and HBeAg(-) patients.

    abstract:AIM:To identify the prevalence of hepatitis B e antigen (HBeAg) and to assess the association of hepatitis B virus (HBV) core promoter mutations and viral load in Indonesian patients. METHODS:Sixty-four patients with chronic hepatitis, 65 with liver cirrhosis and 50 with hepatocellular carcinoma were included in this ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v17.i6.708

    authors: Utama A,Siburian MD,Purwantomo S,Intan MD,Kurniasih TS,Gani RA,Achwan WA,Arnelis,Lelosutan SA,Lukito B,Harmono T,Zubir N,Julius,Soemohardjo S,Lesmana LA,Sulaiman A,Tai S

    更新日期:2011-02-14 00:00:00

  • An ironic case of liver infections: Yersinia enterocolitis in the setting of thalassemia.

    abstract::A 49 years old Vietnamese male with a history of thalassemia, presented with gastrointestinal symptoms and signs of hemolysis. He was diagnosed with yersinia enterocolitis. Yersinia is a gram-negative rod that most frequently occurs in children especially during the winter months. In the current case, the bone marrow ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v19.i37.6296

    authors: Selsky N,Forouhar F,Wu GY

    更新日期:2013-10-07 00:00:00

  • Endoscopic stenting for recurrence-related colorectal anastomotic site obstruction: preliminary experience.

    abstract:AIM:To evaluate the efficacy of stents in treating patients with anastomotic site obstructions due to cancer recurrence following colorectal surgery. METHODS:The medical records of patients who underwent endoscopic self-expanding metal stents (SEMS) insertion for colorectal obstructions between February 2004 and Janua...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i38.13936

    authors: Kim JH,Lee JJ,Cho JH,Kim KO,Chung JW,Kim YJ,Kwon KA,Park DK,Kim JH

    更新日期:2014-10-14 00:00:00

  • Pancreatic encephalopathy and Wernicke encephalopathy in association with acute pancreatitis: a clinical study.

    abstract:AIM:To investigate clinical characteristics and therapy of pancreatic encephalopathy (PE) and Wernicke encephalopathy (WE). METHODS:In a retrospective study of 596 patients with acute pancreatitis (AP), patients with PE were compared to those with WE in regards to history, clinical manifestation, diagnosis, treatment ...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v12.i26.4224

    authors: Sun GH,Yang YS,Liu QS,Cheng LF,Huang XS

    更新日期:2006-07-14 00:00:00

  • Two cases of neuroendocrine carcinoma of the gallbladder.

    abstract::Neuroendocrine carcinoma (NEC) of the gallbladder is a rare subtype of gallbladder tumor. Here, we report two cases of NEC in two patients initially suspected to have gallbladder carcinoma. No specific symptoms or abnormal blood test results were observed preoperatively. Abdominal computed tomography scans indicated i...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v20.i33.11916

    authors: Chen H,Shen YY,Ni XZ

    更新日期:2014-09-07 00:00:00

  • Effect of Jianweiyuyang granule on gastric ulcer recurrence and expression of VEGF mRNA in the healing process of gastric ulcer in rats.

    abstract:AIM:To investigate the effect of Jianweiyuyang (JWYY) granule on gastric ulcer recurrence and its mechanism in the treatment of gastric ulcer in rats. METHODS:Gastric ulcer in rats was induced according to Okeba's method with minor modification and the recurrence model was induced by IL-1beta. The expression of vascul...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v11.i35.5480

    authors: Dai XP,Li JB,Liu ZQ,Ding X,Huang CH,Zhou B

    更新日期:2005-09-21 00:00:00

  • Analysis of ABC (D) stratification for screening patients with gastric cancer.

    abstract:AIM:To evaluate the value of ABC (D) stratification [combination of serum pepsinogen and Helicobacter pylori (H. pylori) antibody] of patients with gastric cancer. METHODS:Ninety-five consecutive patients with gastric cancer were enrolled into the study. The serum pepsinogen I (PG I)/pepsinogen II (PG II) and H. pylor...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v17.i43.4793

    authors: Kudo T,Kakizaki S,Sohara N,Onozato Y,Okamura S,Inui Y,Mori M

    更新日期:2011-11-21 00:00:00

  • Low glucose metabolism in hepatocellular carcinoma with GPC3 expression.

    abstract:AIM:To investigate the relationship between glucose metabolism and glypican-3 (GPC3) expression in hepatocellular carcinoma (HCC). METHODS:Immunohistochemical staining of pathological samples for GPC3 and glucose transporter 1 (GLUT1), and whole-body 18F-FDG PET/CT for measuring tumour glucose uptake were performed in...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v24.i4.494

    authors: Li YC,Yang CS,Zhou WL,Li HS,Han YJ,Wang QS,Wu HB

    更新日期:2018-01-28 00:00:00

  • TECA hybrid artificial liver support system in treatment of acute liver failure.

    abstract:AIM:To assess the efficacy and safety of TECA type hybrid artificial liver support system (TECA-HALSS) in providing liver function of detoxification, metabolism and physiology by treating the patients with acute liver failure (ALF). METHODS:The porcine liver cells (1-2) x 10(10) were separated from the Chinese small s...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v7.i6.826

    authors: Xue YL,Zhao SF,Luo Y,Li XJ,Duan ZP,Chen XP,Li WG,Huang XQ,Li YL,Cui X,Zhong DG,Zhang ZY,Huang ZQ

    更新日期:2001-12-01 00:00:00

  • Endoscopic treatment of gastroparesis.

    abstract::Gastroparesis has traditionally been a largely medically managed disease with refractory symptoms typically falling under the umbrella of the surgical domain. Surgical options include, but are not limited to, gastrostomy, jejunostomy, pyloromyotomy, or pyloroplasty, and the Food and Drug Administration approved gastri...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3748/wjg.v21.i22.6842

    authors: McCarty TR,Rustagi T

    更新日期:2015-06-14 00:00:00

  • Pyogenic liver abscess: an audit of 10 years' experience.

    abstract:AIM:To describe our own experience with pyogenic liver abscesses over the past 10 years and investigate the risk factors associated with failure of initial percutaneous therapy. METHODS:A retrospective study of records of 63 PLA patients presenting between 1998 and 2008 to Australian tertiary referral centre, were rev...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v17.i12.1622

    authors: Pang TC,Fung T,Samra J,Hugh TJ,Smith RC

    更新日期:2011-03-28 00:00:00

  • High-flow nasal oxygen availability for sedation decreases the use of general anesthesia during endoscopic retrograde cholangiopancreatography and endoscopic ultrasound.

    abstract:AIM:To examine whether high-flow nasal oxygen (HFNO) availability influences the use of general anesthesia (GA) in patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic ultrasound (EUS) and associated outcomes. METHODS:In this retrospective study, patients were stratified into 3 eras...

    journal_title:World journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3748/wjg.v22.i47.10398

    authors: Schumann R,Natov NS,Rocuts-Martinez KA,Finkelman MD,Phan TV,Hegde SR,Knapp RM

    更新日期:2016-12-21 00:00:00