Roles of cyclophilins in cancers and other organ systems.

Abstract:

:Cyclophilins are originally identified as cellular binding proteins for the immunosuppressive drug cyclosporin A. Many cyclophilins, including CypA, CypB, CypC, CypD, and Cyp40, have been discovered and shown to be ubiquitously distributed in many types of cells and organ systems. Recent investigations have uncovered many important properties and functions for cyclophilins including peptidyle-prolyl-isomerase activity and protein folding/repair; maintaining mitochondrial functions and involvement in apoptosis; roles in regulation of T-cell function and inflammation; interaction with CD147; and pathogenesis of vascular disease, human immunodeficiency virus infection, and rheumatoid arthritis. Furthermore, the expression and functions of cyclophilins may be correlated with tumor biology of several types of cancers including pancreatic carcinoma. Molecular mechanisms of cyclophilin-mediated biologic events and future directions of research are discussed in this review. Understanding the roles of cyclophilins in cancers and other organ systems will be crucial in determining clinical applications for the treatment or diagnosis of human diseases.

journal_name

World J Surg

journal_title

World journal of surgery

authors

Yao Q,Li M,Yang H,Chai H,Fisher W,Chen C

doi

10.1007/s00268-004-7812-7

keywords:

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

276-80

issue

3

eissn

0364-2313

issn

1432-2323

journal_volume

29

pub_type

杂志文章,评审
  • Risk factors for conversion of laparoscopic colorectal surgery to open surgery: does conversion worsen outcome?

    abstract:INTRODUCTION:The utilization of laparoscopy in colorectal surgery is increasing. However, conversion to open surgery remains relatively high. OBJECTIVE:We evaluated (1) conversion rates in laparoscopic colorectal surgery; (2) the outcomes of converted cases compared with successful laparoscopic and open colorectal ope...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-015-2958-z

    authors: Masoomi H,Moghadamyeghaneh Z,Mills S,Carmichael JC,Pigazzi A,Stamos MJ

    更新日期:2015-05-01 00:00:00

  • The influence of parathyroidectomy on restless legs syndrome in patients with renal hyperparathyroidism.

    abstract:BACKGROUND:Restless legs syndrome (RLS) is a common and poorly understood movement disorder that leads to unpleasant leg sensations. Although RLS can be idiopathic, secondary etiologies such as iron deficiency and renal failure are common. The aim of this prospective cohort study was to evaluate whether RLS is a common...

    journal_title:World journal of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00268-013-2185-4

    authors: Schneider R,Karakas E,Bartsch DK,Schlosser K

    更新日期:2013-12-01 00:00:00

  • Moving from data collection to application: a systematic literature review of surgical capacity assessments and their applications.

    abstract:BACKGROUND:Over the past decade, assessments of surgical capacity in low- and middle-income countries (LMICs) have contributed to our understanding of barriers to the delivery of surgical services in a number of countries. It is yet unclear, however, how the findings of these assessments have been applied and built upo...

    journal_title:World journal of surgery

    pub_type: 杂志文章,评审

    doi:10.1007/s00268-014-2938-8

    authors: Carlson LC,Lin JA,Ameh EA,Mulwafu W,Donkor P,Derbew M,Rodas E,Mkandawire NC,Dhanaraj M,Yangni-Angate H,Sani R,Labib M,Barbero R,Clarke D,Smith MD,Sherman L,Mutyaba FA,Alexander P,Hadley LG,VanRooyen MJ,Kushner AL

    更新日期:2015-04-01 00:00:00

  • Intraoperative determination of PTH concentrations in fine needle tissue aspirates to identify parathyroid tissue during parathyroidectomy.

    abstract:BACKGROUND:Exact tissue identification during parathyroidectomy is essential to successfully cure hyperparathyroidism. PTH level determination from tissue aspirates has been advocated as a "biochemical frozen section" for parathyroid tissue identification. We investigated the sensitivity and specificity of this method ...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-009-0351-5

    authors: Horányi J,Duffek L,Szlávik R,Takács I,Tóth M,Romics L Jr

    更新日期:2010-03-01 00:00:00

  • How to manage thyroid nodules with two consecutive non-diagnostic results on ultrasonography-guided fine-needle aspiration.

    abstract:BACKGROUND:The aim of this study was to investigate the factors for considering surgery on thyroid nodules that had non-diagnostic results on two consecutive cytology examinations. METHODS:A total of 104 thyroid nodules with two consecutive non-diagnostic cytology examinations in 104 patients were investigated. Nodule...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-011-1397-8

    authors: Moon HJ,Kwak JY,Choi YS,Kim EK

    更新日期:2012-03-01 00:00:00

  • Current management of pectus excavatum.

    abstract::Pectus excavatum (PE) is one of the most common anomalies of childhood. It occurs in approximately 1 in every 400 births, with males afflicted 5 times more often than females. PE is usually recognized in infancy, becomes much more severe during adolescent growth years, and remains constant throughout adult life. Sympt...

    journal_title:World journal of surgery

    pub_type: 社论,评审

    doi:10.1007/s00268-003-7025-5

    authors: Fonkalsrud EW

    更新日期:2003-05-01 00:00:00

  • Perioperative Outcomes of Melanoma Patients Undergoing Surgery After Receiving Immunotherapy or Targeted Therapy.

    abstract:BACKGROUND:Traditional chemotherapy agents adversely affect wound healing and need to be held prior to or after surgery. Immune checkpoint inhibitors (ICIs) and targeted agents are now standard of care for the several treatment cancers. We hypothesize that ICI and targeted therapy do not have similar adverse effects on...

    journal_title:World journal of surgery

    pub_type: 杂志文章,评审

    doi:10.1007/s00268-019-05314-2

    authors: Sun J,Kirichenko DA,Chung JL,Carr MJ,Eroglu Z,Khushalani NI,Markowitz J,Messina JL,Sondak VK,Zager JS,Patel SY

    更新日期:2020-04-01 00:00:00

  • Pattern of organ failure following severe trauma.

    abstract::Multiple organ failure (MOF) is considered to be the leading cause of death after severe trauma. Although there is extensive literature on MOF, little is known about the pattern, sequence, and onset of this clinical syndrome. The first goal of this clinical study was to define MOF; the second was to assess the typical...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s002689900067

    authors: Regel G,Grotz M,Weltner T,Sturm JA,Tscherne H

    更新日期:1996-05-01 00:00:00

  • Treatment of hepatic metastases from gastroenteropancreatic neuroendocrine tumors: role of liver transplantation.

    abstract::The role of liver transplantation in malignancy has been discussed, but controversially, over the past two decades. This is particularly true for hepatic metastases from neuroendocrine tumors, which have a wide variety of primary tumor localizations, morphologic types, functional activities, and clinical presentations...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-001-0016-5

    authors: Ringe B,Lorf T,Döpkens K,Canelo R

    更新日期:2001-06-01 00:00:00

  • Correction to: Advanced Modeling to Predict Pneumonia in Combat Trauma Patients.

    abstract::In the original article, the units indicated on the y-axes of Fig. 3 are incorrectly labelled. The correct label is pg/mL. Following is the corrected Fig. 3. ...

    journal_title:World journal of surgery

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s00268-020-05520-3

    authors: Bradley M,Dente C,Khatri V,Schobel S,Lisboa F,Shi A,Hensman H,Kirk A,Buchman TG,Elster E

    更新日期:2020-07-01 00:00:00

  • Validation of an Electronic Surgical Outcomes Database at Mbarara Regional Referral Hospital, Uganda.

    abstract:BACKGROUND:Accurate, complete and sustainable methods of tracking patients and outcomes in low-resource settings are imperative as we launch efforts to improve surgical care globally. The Surgical services QUality Assessment Database (SQUAD) at the Mbarara Regional Referral Hospital in Uganda is one of very few electro...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-017-4172-7

    authors: Anderson GA,Ilcisin L,Ngonzi J,Ttendo S,Twesigye D,Benitez NP,Firth P,Nehra D

    更新日期:2018-01-01 00:00:00

  • Hepatic surgery and hepatic surgical anatomy: historical partners in progress.

    abstract::Whether for hepatic trauma or transplantation, a surgeon's knowledge of hepatic anatomy commonly determines a patient's outcome. The first medically relevant anatomic studies of the liver emerged with the endeavors of Herophilus and Erasistratus between 310 and 280 bc. Yet it was not until after the development of ane...

    journal_title:World journal of surgery

    pub_type: 传,历史文章,杂志文章

    doi:10.1007/s002689900238

    authors: McClusky DA 3rd,Skandalakis LJ,Colborn GL,Skandalakis JE

    更新日期:1997-03-01 00:00:00

  • Increased platelet counts after transthoracic en bloc resection for esophageal cancer is associated with significantly improved survival.

    abstract:BACKGROUND:We analyzed perioperative platelet counts as a potential clinical marker for survival after transthoracic en bloc resection for esophageal cancer. Recent data described preoperative thrombocytosis in malignancies to be associated with poor prognosis. METHODS:A retrospective analysis from a prospective datab...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-010-0707-x

    authors: Ling FC,Vallböhmer D,Hoelscher AH,Schmidt D,Bollschweiler E,Schneider PM

    更新日期:2010-11-01 00:00:00

  • Team consistency and occurrences of prolonged operative time, prolonged hospital stay, and hospital readmission: a retrospective analysis.

    abstract:BACKGROUND:Human factors research has suggested benefits of consistent teams yet no surgical team consistency measures have been established for teamwork improvement initiatives. METHODS:Retrospective analysis was conducted of teams performing consecutive elective procedures of unilateral primary total knee and hip re...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-014-2866-7

    authors: Xiao Y,Jones A,Zhang BB,Bennett M,Mears SC,Mabrey JD,Kennerly D

    更新日期:2015-04-01 00:00:00

  • Emergency department thoracotomy: survival of the least expected.

    abstract::Although emergency department thoracotomy (EDT) is often considered a controversial "last chance" method of resuscitation, we hypothesized that EDT performed in a busy urban Level I trauma center has significant salvage rates despite the absence of traditional survival predictors. A retrospective review revealed that ...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-007-9392-9

    authors: Seamon MJ,Fisher CA,Gaughan JP,Kulp H,Dempsey DT,Goldberg AJ

    更新日期:2008-04-01 00:00:00

  • Assessment of Capacity to Meet Lancet Commission on Global Surgery Indicators in the Federal Capital Territory, Abuja, Nigeria.

    abstract:BACKGROUND:This is a baseline assessment of surgical capacity in the Federal Capital Territory (FCT), in preparation for the creation of a National Surgical, Obstetric, Anesthesia, and Nursing Plan. METHODS:In October 2017, all 10 of the 11 secondary hospitals in FCT that provide surgical and/or obstetric care were su...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-018-4835-z

    authors: Anderson JE,Ndajiwo AB,Nuhu SA,Lawal OA,Amedu JO,Ameh EA

    更新日期:2019-03-01 00:00:00

  • Changes in metabolic profile and adipoinsular axis in morbidly obese premenopausal females treated with restrictive bariatric surgery.

    abstract:BACKGROUND:The aim of the present study was to evaluate the effects of surgically induced weight loss on the metabolic profile and adipocytokine levels in premenopausal morbidly obese females. METHODS:Twenty premenopausal morbidly obese (MO) women with a median age of 34 years (range: 24-48 years) and a median body ma...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-011-1165-9

    authors: Marantos G,Daskalakis M,Karkavitsas N,Matalliotakis I,Papadakis JA,Melissas J

    更新日期:2011-09-01 00:00:00

  • Low Incidence of Lymph Node Metastasis After Resection of Hepatitis Virus-Related Intrahepatic Cholangiocarcinoma.

    abstract:BACKGROUND AND OBJECTIVES:We determined the rates of initial lymph node metastasis following curative resection of mass-forming type-intrahepatic cholangiocarcinoma (ICC) in patients with and without hepatitis virus infection. METHODS:We enrolled 87 patients between January 2000 and December 2013 with ICC without preo...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-016-3843-0

    authors: Iida H,Kaibori M,Tanaka S,Takemura S,Wada H,Hirokawa F,Nakai T,Hayashi M,Eguchi H,Kubo S

    更新日期:2017-04-01 00:00:00

  • Gastroschisis and omphalocele.

    abstract::It has been widely acknowledged that exomphalos and gastroschisis are two different clinical entities. Their etiology and pathogenesis, however, remain controversial. Several techniques are available for making a prenatal diagnosis of these as well as many other malformations. Some prenatal treatment is possible, but ...

    journal_title:World journal of surgery

    pub_type: 杂志文章,评审

    doi:10.1007/BF01658701

    authors: Molenaar JC,Tibboel D

    更新日期:1993-05-01 00:00:00

  • Concomitant analysis of the epidermal growth factor receptor family in esophageal cancer: overexpression of epidermal growth factor receptor mRNA but not of c-erbB-2 and c-erbB-3.

    abstract::The epidermal growth factor receptor family consists of four closely related transmembrane receptors: epidermal growth factor receptor (EGF-R), c-erbB-2, c-erbB-3, and c-erbB-4. Overexpression of each receptor may lead to cell transformation and contributes to tumor progression in various malignancies. Although these ...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s002689900616

    authors: Friess H,Fukuda A,Tang WH,Eichenberger A,Furlan N,Zimmermann A,Korc M,Büchler MW

    更新日期:1999-10-01 00:00:00

  • Oncological Safety and Technical Feasibility of Nipple-Sparing Mastectomy for Breast Cancer: The Hong Kong Experience.

    abstract:BACKGROUND:Nipple-sparing mastectomy (NSM) has gained widespread popularity in recent years. Nonetheless, patient selection, technical consideration and oncological safety of its extension to breast cancer treatment remain uncertain. Few publications have reviewed the application of NSM in Asian populations. METHODS:W...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-017-4197-y

    authors: Chan YH,Yau WM,Cheung PS

    更新日期:2018-05-01 00:00:00

  • Improving the approach to organ donation: a review.

    abstract::Organ transplantation continues to be hindered by a limited supply of organs. A significant percentage of potential organ donors are lost to either medical failure or inability to obtain consent for donation. In a surgical intensive care unit (ICU) we have refocused our efforts toward aggressive resuscitation, directe...

    journal_title:World journal of surgery

    pub_type: 杂志文章,评审

    doi:10.1007/pl00012362

    authors: Jenkins DH,Reilly PM,Schwab CW

    更新日期:1999-07-01 00:00:00

  • Risk Factors for Early Postoperative Small Bowel Obstruction After Anterior Resection for Rectal Cancer.

    abstract:PURPOSE:The aim of the study was to evaluate risk factors for small bowel obstruction (SBO) in early postoperative period after anterior resection for rectal cancer. METHODS:Patients who underwent anterior resection (AR) [high AR (HAR) or low AR (LAR)] for rectal cancer between January 2009 and April 2016 were enrolle...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-017-4152-y

    authors: Suwa K,Ushigome T,Ohtsu M,Narihiro S,Ryu S,Shimoyama Y,Okamoto T,Yanaga K

    更新日期:2018-01-01 00:00:00

  • Surgery for digestive malignancies in patients with psychiatric disorders.

    abstract:BACKGROUND:The psychiatric population has been reported to be accompanied with a higher morbidity and mortality in several situations. However, little is known about the effect of co-morbid psychiatric disorders on surgical risk during major digestive surgery for malignancies. Our purpose in the present study, therefor...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-007-9267-0

    authors: Aoyanagi N,Iizuka I,Watanabe M

    更新日期:2007-12-01 00:00:00

  • Laparoscopic Proximal Gastrectomy Maintains Body Weight and Skeletal Muscle Better Than Total Gastrectomy.

    abstract:BACKGROUND:Laparoscopic proximal gastrectomy (LPG) is performed as a function-preserving surgery for patients with early proximal gastric malignant tumors; however, whether LPG has advantages postoperatively compared with laparoscopic total gastrectomy (LTG) is debatable, especially with regard to nutritional outcomes....

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-018-4625-7

    authors: Sugiyama M,Oki E,Ando K,Nakashima Y,Saeki H,Maehara Y

    更新日期:2018-10-01 00:00:00

  • The faltering solid organ donor pool in the United States (2001-2010).

    abstract:BACKGROUND:Organ shortage is the greatest challenge facing the field of organ transplantation today. Use of more organs of marginal quality has been advocated to address the shortage. METHOD:We examined the pattern of donation and organ use in the United States as shown in the Organ Procurement and Transplantation Net...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-012-1748-0

    authors: Saidi RF,Markmann JF,Jabbour N,Li Y,Shah SA,Cosimi AB,Bozorgzadeh A

    更新日期:2012-12-01 00:00:00

  • Building a comprehensive genomic program for hepatocellular carcinoma.

    abstract:BACKGROUND:Hepatocellular carcinoma (HCC) is the most common primary liver cancer, causing approximately 660,000 deaths worldwide annually. The preferred treatment of HCC is surgical resection or orthotopic liver transplantation (OLT) for patients meeting specific criteria. For patients outside these criteria, options ...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-010-0954-x

    authors: Harring TR,Guiteau JJ,Nguyen NT,Cotton RT,Gingras MC,Wheeler DA,O'Mahony CA,Gibbs RA,Brunicardi FC,Goss JA

    更新日期:2011-08-01 00:00:00

  • Sternocleidomastoid muscle myocutaneous flap for corrosive pharyngoesophageal strictures.

    abstract:BACKGROUND:Strictures at the pharyngoesophageal junction represent a subgroup of corrosive esophageal strictures requiring a specialized management approach. Non-dilatable cricopharyngeal strictures need surgical intervention. We report the use of the sternocleidomastoid muscle myocutaneous inlay flap (SCMMIF) for reco...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-007-9120-5

    authors: Ananthakrishnan N,Parthasarathy G,Maroju NK,Kate V

    更新日期:2007-08-01 00:00:00

  • Limitations of Tc99m-MIBI-SPECT imaging scans in persistent primary hyperparathyroidism.

    abstract:BACKGROUND:In primary hyperparathyroidism (PHPT) the predictive value of technetium 99m sestamibi single emission computed tomography (Tc99m-MIBI-SPECT) for localizing pathological parathyroid glands before a first parathyroidectomy (PTx) is 83-100%. Data are scarce in patients undergoing reoperative parathyroidectomy ...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-010-0818-4

    authors: Witteveen JE,Kievit J,Stokkel MP,Morreau H,Romijn JA,Hamdy NA

    更新日期:2011-01-01 00:00:00

  • Total colectomy improves altered distribution of regulatory T cells in patients with ulcerative colitis.

    abstract:BACKGROUND:It is now generally believed that regulatory T cells (Tregs) play an important role in peripheral tolerance, and a defect in Tregs is considered one of the most important factors in the induction of various kinds of autoimmune disease including ulcerative colitis (UC). Here, we examined the change in frequen...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-005-0301-9

    authors: Furihata M,Sawada T,Okada T,Ishizuka M,Horie T,Takagi K,Nagata H,Kubota K

    更新日期:2006-04-01 00:00:00