Abstract：
BACKGROUND AND OBJECTIVE:Infliximab is a chimeric monoclonal antibody that binds to tumor necrosis factor alpha and blocks the inflammatory response. The purpose of this study was to assess the effects of infliximab in patients with severe and refractory psoriasis. PATIENTS AND METHOD:Eleven patients with severe and refractory psoriasis were included in an open-label clinical trial. Patients received infliximab 5 mg/kg intravenously at weeks 0, 2, 6 and every 8 weeks. Psoriasis Assessment and Severity Index (PASI) and BSA (Body Surface Assessment) were used to monitor disease activity with each dose. Results at weeks 6 and 30 are shown. RESULTS:90% of patients improved their PASI and BSA basal scores early at sixth week, achieving 63.6% (PASI75) and 72.7% (BSA50). This improvement was maintained until the 30th week (54.5% and 72.7%, respectively). Infliximab was well tolerated and there was no significant adverse reaction. CONCLUSIONS:Infliximab seems an effective therapy for severe and refractory psoriasis.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
Mahiques Santos L,Martínez-Menchón T,Sánchez Carazo JL,Oliver Martínez V,Soriano Navarro CJ,Fortea Baixauli JMdoi
10.1016/s0025-7753(04)74634-5keywords:
subject
Has Abstractpub_date
2004-11-13 00:00:00pages
657-8issue
17eissn
0025-7753issn
1578-8989pii
S0025-7753(04)74634-5journal_volume
123pub_type
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