Abstract:
:Splice acceptors with the genomic NAGNAG motif may cause NAG insertion-deletions in transcripts, occur in 30% of human genes and are functional in at least 5% of human genes. We found five significant biases indicating that their distribution is nonrandom and that they are evolutionarily conserved and tissue-specific. Because of their subtle effects on mRNA and protein structures, these splice acceptors are often overlooked or underestimated, but they may have a great impact on biology and disease.
journal_name
Nat Genetjournal_title
Nature geneticsauthors
Hiller M,Huse K,Szafranski K,Jahn N,Hampe J,Schreiber S,Backofen R,Platzer Mdoi
10.1038/ng1469keywords:
subject
Has Abstractpub_date
2004-12-01 00:00:00pages
1255-7issue
12eissn
1061-4036issn
1546-1718pii
ng1469journal_volume
36pub_type
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