5-HT7, but not 5-HT2B, receptors mediate hypotension in vagosympathectomized rats.

abstract：:In urethane-anesthetized rats the intrathecal (i.t.) injection of 100 nmol anandamide produced a hypotensive effect (-19.3+/-1.6 mm Hg; n=6) that was mimicked by i.t. administration of 0.25 nmol calcitonin gene-related peptide (CGRP; -26.2+/-1.8 mm Hg, n=4). Both effects were antagonized either by the CGRP receptor an...

journal_title：European journal of pharmacology

authors： García Mdel C,Adler-Graschinsky E,Celuch SM

更新日期：2006-02-17 00:00:00

abstract：:The effects of CS-518 (sodium 2-(1-imidazolylmethyl)-4,5-dihydrobenzo[b]thiophene-6-carboxylate) , a thromboxane A2 synthase inhibitor, on eosinophil accumulation and activation were investigated in an experimental asthmatic guinea pig model and several cellular models. In the in vivo studies, CS-518 inhibited the bip...

journal_title：European journal of pharmacology

authors： Itoh K,Mukaiyama O,Satoh Y,Yamaguchi T,Iizuka Y

更新日期：1993-08-03 00:00:00

abstract：:Pretreatment with the catecholamine precursor L-DOPA but not the narcotic antagonist naloxone suppressed the tremorigenic effect of oxotremorine in mice. However, when animals were pretreated with both L-DOPA and several different doses of naloxone, there was a dose-related potentiation of the antitremor effect of L-D...

journal_title：European journal of pharmacology

authors： Quock RM,Lucas TS

更新日期：1983-11-25 00:00:00

abstract：:We investigated whether or not insulin and cAMP-elevating agents induce the proliferation of adult rat hepatocytes during the early and late phases of primary culture. Adult rat hepatocytes synthesized a significant amount of DNA when cultured in the presence of 10(-7) M insulin for 3 h. Under these conditions, the nu...

journal_title：European journal of pharmacology

authors： Kimura M,Ogihara M

更新日期：1997-05-26 00:00:00

abstract：:The influence of (+/-)-tamsulosin, a selective alpha 1A-adrenoceptor antagonist, on the positive inotropic effect and the accumulation of inositol phosphates that are induced via alpha 1-adrenoceptors was studied in comparison with that of another alpha 1A-adrenoceptor ligand oxymetazoline in the rabbit ventricular my...

journal_title：European journal of pharmacology

authors： Yang HT,Endoh M

更新日期：1996-10-03 00:00:00

abstract：:cRNA encoding the human IsK protein was injected into Xenopus oocytes and the expressed channels were investigated using the two-microelectrode voltage-clamp method. The novel class III antiarrhythmic NE-10064 (1-[[[5-(4-chlorophenyl)-2-furanyl]methylene]-amino]-3- [4-(4-methyl-1-piperazinyl)-butyl]-2,4-imidazolidined...

journal_title：European journal of pharmacology

authors： Busch AE,Herzer T,Takumi T,Krippeit-Drews P,Waldegger S,Lang F

更新日期：1994-10-13 00:00:00

abstract：:Increasing stimulation frequency and monensin were utilized in attempts to enhance Na+ influx and thereby elicit the maximum rate of ouabain-sensitive 86Rb+ uptake in rat atrial muscle. Increasing stimulation frequency between 0 and 9 Hz enhanced the rate of ouabain-sensitive 86Rb+ uptake, whereas the uptake rate appe...

journal_title：European journal of pharmacology

authors： Kennedy RH,Seifen E,Kafiluddi R

更新日期：1986-09-23 00:00:00

abstract：:beta-Carbolines (including harmane and pinoline) stimulate insulin secretion by a mechanism that may involve interaction with imidazoline I(3)-receptors but which also appears to be mediated by actions that are additional to imidazoline receptor agonism. Using the MIN6 beta-cell line, we now show that both the imidazo...

journal_title：European journal of pharmacology

authors： Squires PE,Hills CE,Rogers GJ,Garland P,Farley SR,Morgan NG

更新日期：2004-10-06 00:00:00

abstract：:Using urethane-anesthetized rats, we examined whether an activation of nuclear factor kappa B is involved in the corticotropin-releasing factor-induced increase in plasma levels of catecholamines. An intracerebroventricularly administered corticotropin-releasing factor (1.5 nmol/animal)-induced increase of plasma cate...

journal_title：European journal of pharmacology

authors： Okada S,Yamaguchi-Shima N,Shimizu T,Arai J,Yorimitsu M,Yokotani K

更新日期：2008-04-14 00:00:00

abstract：:Pressor and bradycardiac responses induced by electrical stimulation of the mesencephalic reticular formation in urethane-anesthetized rats were used as model of neurogenic hypertension. Oxytocin (OXT) and prolyl-leucyl-glycinamide (OXT-(7-9] administered into the fourth cerebral ventricle markedly attenuated the magn...

journal_title：European journal of pharmacology

authors： Versteeg CA,Cransberg K,De Jong W,Bohus B

更新日期：1983-10-14 00:00:00

abstract：:The carrier for 5-hydroxytryptamine (5-HT) of the 5-HT storage organelles of blood platelets was characterized by [3H]dihydrotetrabenazine binding and [125I]azidoiodokentanserin photoaffinity labeling. [3H]Dihydrotetrabenazine bound with high affinity to membrane preparations from different animal species. The [3H]dih...

journal_title：European journal of pharmacology

authors： Cesura AM,Bertocci B,Da Prada M

更新日期：1990-09-04 00:00:00

abstract：:Acetylcholine caused no relaxation of a rubbed strip from rabbit aorta (RASR) which was precontracted with phenylephrine. When the same strip was taken into epithelium-intact guinea-pig trachea, acetylcholine produced a slow-developing relaxation which was antagonized by atropine but not by propranolol, indomethacin, ...

journal_title：European journal of pharmacology

authors： Ilhan M,Sahin I

更新日期：1986-11-19 00:00:00

abstract：:Adjuvant arthritis in rats was induced by a single subcutaneous injection of Freund adjuvant into a hind paw. The injected paws' mean volume increased continuously by 80 +/- 26% after 6 h (acute local response). The injected paw displayed a biphasic response peaking at day 1-2 decreasing to day 5, then increased to da...

journal_title：European journal of pharmacology

authors： Al-Haboubi HA,Zeitlin IJ

更新日期：1982-02-26 00:00:00

abstract：:Unlike classical antipsychotic drugs, clozapine activates the hypothalamo-pituitary-adrenal axis and induces a specific regional pattern of Fos-protein expression in the rat forebrain. Whether corticosterone plays a role in the clozapine-induced Fos response is the subject of this study. Some rats were adrenalectomize...

journal_title：European journal of pharmacology

authors： Sebens JB,Middelveld RJ,Koch T,Ter Horst GJ,Korf J

更新日期：2001-04-06 00:00:00

abstract：:The polyphenolic flavonoid silymarin that is the milk thistle extract has been found to possess an anti-cancer effect against various human epithelial cancers. In this study, to explore the regulative effect of silymarin on human ovarian cancer line A2780s and PA-1 cells, 3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltet...

journal_title：European journal of pharmacology

authors： Fan L,Ma Y,Liu Y,Zheng D,Huang G

更新日期：2014-11-15 00:00:00

abstract：:We investigated protein kinase C participation in the contractile response to 5-hydroxytryptamine (5-HT), and in the interaction between 5-HT and endothelin-1, in aortas from control and diabetic rats. Diabetic rats display attenuated reactivity to 5-HT (i.e., approximately 47% of control maximum). The protein kinase ...

journal_title：European journal of pharmacology

authors： James GM,Hodgson WC

更新日期：1997-03-12 00:00:00

abstract：:5-Cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-pyrimidin-4-ylamine (BAY 41-2272) is a potent soluble guanylyl cyclase stimulator in a nitric oxide (NO)-independent manner. The relaxant effect of BAY 41-2272 was investigated in rabbit and human corpus cavernosum in vitro. BAY 41-2272 (0.01-10 micr...

journal_title：European journal of pharmacology

authors： Baracat JS,Teixeira CE,Okuyama CE,Priviero FB,Faro R,Antunes E,De Nucci G

更新日期：2003-09-12 00:00:00

abstract：:The dihydropyridine Ca2+ channel blocker nimodipine and the dihydropyridine Ca2+ channel activator BayK 8644 (1,4-dihydropyridine-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl)-py ridine- 5-carboxylate) were administered to drug-naive mice and rats that were tested for intravenous cocaine self-administration. A rang...

journal_title：European journal of pharmacology

authors： Kuzmin A,Semenova S,Ramsey NF,Zvartau EE,Van Ree JM

更新日期：1996-01-04 00:00:00

abstract：:Osthole is a coumarin extracted from Cnidium monnieri (L.) Cusson. The medicinal plant is widely used in Vietnamese as well as Chinese traditional medicine as a vasodilating and antihypertensive agent. Here we have tested the proposition that the block of Ca(v)1.2 channels is mainly responsible for its vascular activi...

journal_title：European journal of pharmacology

authors： Fusi F,Sgaragli G,Ha le M,Cuong NM,Saponara S

更新日期：2012-04-05 00:00:00

abstract：:We examined the effect of HSR-81 ((-)-(R)-alpha-[(tert-butylamino)methyl]-2-chloro-4-hydroxybenzyl alcohol L-tartrate), a newly developed, potent and selective beta 2-adrenoceptor agonist, as well as ritodrine and isoproterenol, on the spontaneous rhythmic contraction in uteri isolated from late pregnant, middle pregn...

journal_title：European journal of pharmacology

authors： Ohashi T,Hashimoto S,Morikawa K,Kato H,Ito Y,Asano M,Azuma H

更新日期：1996-07-04 00:00:00

abstract：:The present study was an attempt to answer the question whether the local anesthetic [3H]tetracaine labels sodium channels in mouse brain synaptosomes. Binding of [3H]tetracaine had a Kd of 0.19 microM and a Bmax ranging from 3.7 to 5.2 pmol/mg of protein. Local anesthetics other than tetracaine and cocaine-related co...

journal_title：European journal of pharmacology

authors： Reith ME,Kim SS,Lajtha A

更新日期：1987-11-10 00:00:00

abstract：:It has been shown that analgesics such as morphine, lidocaine and clonidine increase the release of spinal acetylcholine. Acetylcholine may therefore play an important role in the regulation of spinal pain threshold. Since behavioral as well as in vitro studies have shown a clear involvement of GABA (gamma-amino butyr...

journal_title：European journal of pharmacology

authors： Kommalage M,Höglund AU

更新日期：2005-11-21 00:00:00

abstract：:Internal and external carotid vascular resistances were measured, in anaesthetized monkeys, to asses the direct cranial vascular effects of i.v. methysergide, pizotifen and ergotamine, and their effects on the cranial vascular responses to the constrictors 5-hydroxytryptamine and noradrenaline and the dilators histami...

journal_title：European journal of pharmacology

authors： Mylecharane EJ,Spira PJ,Misbach J,Duckworth JW,Lance JW

更新日期：1978-03-01 00:00:00

abstract：:It was previously shown that haloperidol, but not clozapine, induced intense rat catalepsy when co-administered with delta-9-tetrahydrocannabinol. The present study investigated whether similar alterations could be observed on striatal c-Fos immunoreactivity after administration of the same drug combinations. Western ...

journal_title：European journal of pharmacology

authors： Marchese G,Sanna A,Casu G,Casti P,Spada GP,Ruiu S,Pani L

更新日期：2008-11-19 00:00:00

abstract：:The responsiveness of the guinea-pig esophageal muscularis mucosae to arachidonic acid (AA) and its cyclooxygenase and lipoxygenase metabolites was examined in vitro. AA (0.1-30 microM) produced a concentration-dependent contraction of the muscularis mucosae (mean EC50 +/- S.E.M. = 5.1 +/- 1.0 microM). The contraction...

journal_title：European journal of pharmacology

authors： Kamikawa Y,Fujinuma S,Shimo Y

更新日期：1985-08-07 00:00:00

abstract：:Many atypical antipsychotic drugs, such as olanzapine, induce significant weight gain. However, ziprasidone produces minimal weight gain, the mechanism of which remains unclear. The aim of the present study was to investigate whether ziprasidone would reduce the acute effect of olanzapine on feeding behaviour. The res...

journal_title：European journal of pharmacology

authors： Kirk SL,Neill JC,Jones DN,Reynolds GP

更新日期：2004-11-28 00:00:00

abstract：:CysLT1 receptors are known to be involved in the pathogenesis of asthma. However, the functional roles of CysLT2 receptors in this condition have not been determined. The purpose of this study is to develop an experimental model of CysLT2 receptor-mediated LTC4-induced lung air-trapping in guinea pigs and use this mod...

journal_title：European journal of pharmacology

authors： Sekioka T,Kadode M,Yonetomi Y,Kamiya A,Fujita M,Nabe T,Kawabata K

更新日期：2017-01-05 00:00:00

abstract：:The cardiac plexus, which contains parasympathetic ganglia, plays an important role in regulating cardiac function. Histamine is known to excite intracardiac ganglion neurons, but the underlying mechanism is obscure. In the present study, therefore, the effect of histamine on rat intracardiac ganglion neurons was inve...

journal_title：European journal of pharmacology

authors： Sato A,Arichi S,Kojima F,Hayashi T,Ohba T,Cheung DL,Eto K,Narushima M,Murakoshi H,Maruo Y,Kadoya Y,Nabekura J,Ishibashi H

更新日期：2020-11-05 00:00:00

abstract：:We have previously shown that, in porcine aortic smooth muscle cells, endoplasmic reticulum (ER) stressor thapsigargin simultaneously activate the mitochondrial caspase-dependent death cascade and an extracellular signal-regulated kinase (ERK)-dependent pathway, which inhibits the caspase-independent death pathway. Ou...

journal_title：European journal of pharmacology

authors： Lin KC,Liu PS,Peng PY,Chueh SH

更新日期：2012-07-05 00:00:00

abstract：:The aim of this study has been to investigate the antiplatelet activity of a new series of thienylacylhydrazone derivatives analogous to the lead compound LASSBio-294 ((2-thienylidene) 3,4-methylenedioxybenzoylhydrazine). The antiplatelet effect was investigated in rabbit and human platelet rich plasma stimulated by a...

journal_title：European journal of pharmacology

authors： Brito FC,Kummerle AE,Lugnier C,Fraga CA,Barreiro EJ,Miranda AL

更新日期：2010-07-25 00:00:00