An evidence-based analysis of the antibacterial effectiveness of intracanal medicaments.


:The authors reviewed the literature evaluating the antibacterial effectiveness of intracanal medicaments used in the management of apical periodontitis. A PICO (problem, intervention, comparison, outcome) strategy was developed to identify studies dealing with calcium hydroxide, phenolic derivatives, iodine-potassium iodide, chlorhexidine, and formocresol. The final inclusion/exclusion criteria eliminated all papers except five that evaluated calcium hydroxide. The total sample size in the included studies was 164 teeth. Microbiologic sampling was performed before endodontic treatment (S1), after instrumentation and irrigation (S2), and after intracanal medication (S3). At S2, 62% of canals were positive. After medication, 27% still showed detectable growth. Of cultures that were positive at S2, 45% were still positive at S3. Most studies did not address issues of culture reversals or false positive and false negative cultures. The main component of antibacterial action appears to be associated with instrumentation and irrigation, although canals cannot be reliably rendered bacteria free. Calcium hydroxide remains the best medicament available to reduce residual microbial flora further.


J Endod


Journal of endodontics


Law A,Messer H





Has Abstract


2004-10-01 00:00:00














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    abstract:INTRODUCTION:This randomized clinical trial assessed the effect of preoperative intraoral cryotherapy application on the success rate of inferior alveolar nerve blocks (IANBs) in patients with symptomatic irreversible pulpitis (SIP). METHODS:One hundred four patients with SIP were randomly distributed into 2 groups: c...

    journal_title:Journal of endodontics

    pub_type: 杂志文章,随机对照试验


    authors: Topçuoğlu HS,Arslan H,Topçuoğlu G,Demirbuga S

    更新日期:2019-08-01 00:00:00

  • Growth and differentiation factor-5 regulates the growth and differentiation of human dental pulp cells.

    abstract:INTRODUCTION:Growth and differentiation factor-5 (GDF-5) is a multifunctional protein that regulates the development and repair in many tissues. The purpose of this study was to investigate whether GDF-5 may influence the proliferation, differentiation, and collagen turnover of human dental pulp cells. METHODS:Human d...

    journal_title:Journal of endodontics

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    authors: Chang MC,Lin LD,Tseng HC,Chang BE,Chan CP,Lee SY,Chang HH,Lin PS,Tseng SK,Jeng JH

    更新日期:2013-10-01 00:00:00

  • Gingival squamous cell carcinoma mimicking a dentoalveolar abscess: report of a case.

    abstract::Because of its close proximity to teeth and periodontium, gingival squamous cell carcinoma (SCC) can sometimes mimic tooth-related benign inflammatory conditions, resulting in misdiagnosis. In this study we report a case of gingival SCC that mimicked a dentoalveolar abscess of endodontic origin in its early presentati...

    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Lee JJ,Cheng SJ,Lin SK,Chiang CP,Yu CH,Kok SH

    更新日期:2007-02-01 00:00:00

  • Prevalence of periapical radiolucency and root canal treatment: a systematic review of cross-sectional studies.

    abstract:INTRODUCTION:Cross-sectional studies describe the health status of a population and measure the prevalence of disease or treatment. Neither the prevalence of periapical radiolucency, a surrogate for disease, nor the prevalence of root canal treatment have been subjected to a systematic review, which is the highest leve...

    journal_title:Journal of endodontics

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    authors: Pak JG,Fayazi S,White SN

    更新日期:2012-09-01 00:00:00

  • Long-term seal provided by some root-end filling materials.

    abstract::A tight and long-lasting seal of root-end fillings is of prime clinical importance. A hundred standard bovine root sections, each 3 mm high and with a central pulp lumen of 2.6 mm in diameter, were filled with five commonly used or potential root-end filling materials. At 24 h, or at 3, 6, or 12 months after filling, ...

    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Wu MK,Kontakiotis EG,Wesselink PR

    更新日期:1998-08-01 00:00:00

  • Effect of Using Different Vehicles on the Physicochemical, Antimicrobial, and Biological Properties of White Mineral Trioxide Aggregate.

    abstract:INTRODUCTION:This study evaluated the physicochemical, antimicrobial, and biological properties of white mineral trioxide aggregate (MTA) mixed with aqueous and propylene glycol extracts of Arctium lappa L. and Casearia sylvestris Sw. METHODS:The setting-time test was performed according to American Society for Testin...

    journal_title:Journal of endodontics

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    authors: Cavenago BC,Del Carpio-Perochena AE,Ordinola-Zapata R,Estrela C,Garlet GP,Tanomaru-Filho M,Weckwerth PH,de Andrade FB,Duarte MAH

    更新日期:2017-05-01 00:00:00

  • Combined Endodontic Therapy and Intentional Replantation for the Treatment of Palatogingival Groove.

    abstract::A palatogingival groove is an anatomic malformation that predisposes the involved tooth to a severe periodontal defect. When the condition is complicated by pulpal necrosis, affected teeth often present a dilemma in terms of diagnosis and treatment planning. In this report, we describe the case of a patient with a max...

    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Garrido I,Abella F,Ordinola-Zapata R,Duran-Sindreu F,Roig M

    更新日期:2016-02-01 00:00:00

  • Cracked Teeth and Poor Oral Masticatory Habits: A Matched Case-control Study in China.

    abstract:INTRODUCTION:Previous studies have suggested that masticatory forces are associated with cracked teeth, but it is not clear which specific poor oral masticatory habits may be more likely to cause cracks. The aim of this study was to quantitatively assess risk factors for cracked teeth among poor oral masticatory habits...

    journal_title:Journal of endodontics

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    authors: Qiao F,Chen M,Hu X,Niu K,Zhang X,Li Y,Wu Z,Shen Z,Wu L

    更新日期:2017-06-01 00:00:00

  • Bleaching effect of sodium percarbonate on discolored pulpless teeth in vitro.

    abstract::The purpose of this study was to evaluate the bleaching effect of sodium percarbonate on artificially stained pulpless teeth. Twenty extracted human mandibular premolars were stained by immersing them in human blood mixed with iron sulfide, and divided into three test groups and one control group. The following bleach...

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    authors: Kaneko J,Inoue S,Kawakami S,Sano H

    更新日期:2000-01-01 00:00:00

  • Evaluation of Pulp Response to Novel Bioactive Glass Pulp Capping Materials.

    abstract:INTRODUCTION:This study aimed to investigate dental pulp responses to novel bioactive glass (BG) pulp capping materials after direct pulp capping in vivo. METHODS:Novel BG pulp capping materials are composed of powder and fluid. The powder is BG (82.36% SiO2, 15.36% CaO, and 2.28% P2O5), and the fluid is provided in 2...

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    authors: Long Y,Liu S,Zhu L,Liang Q,Chen X,Dong Y

    更新日期:2017-10-01 00:00:00

  • Effectiveness of intracanal irrigants and medications against the yeast Candida albicans.

    abstract::An in vitro study was conducted to determine the susceptibility of the yeast Candida albicans to various intracanal irrigants and medications. The minimum inhibitory concentration (MIC) of sodium hypochlorite, hydrogen peroxide, chlorhexidine digluconate, and aqueous calcium hydroxide that is required to kill a standa...

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    authors: Ferguson JW,Hatton JF,Gillespie MJ

    更新日期:2002-02-01 00:00:00

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    abstract::The purpose of this study was to evaluate the efficacy of digital subtraction radiography using a direct digital imaging system in the follow-up study of endodontically treated teeth. The RVG-S was used as a direct digital imaging system. The intraimage variation of the original RVG-S image caused by dark current and ...

    journal_title:Journal of endodontics

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    authors: Yoshioka T,Kobayashi C,Suda H,Sasaki T

    更新日期:2002-08-01 00:00:00

  • Bacterial removal promoted by 2 single-file systems: Wave One and One Shape.

    abstract:INTRODUCTION:Different single-file systems are available for endodontic treatment; however, comparative studies are scarce. Thus, the present study evaluated bacterial reduction promoted by 2 single-file systems: Wave One (Dentsply Maillefer, Ballaigues, Switzerland) and One Shape (Micromega, Besancon, France). METHOD...

    journal_title:Journal of endodontics

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    authors: Nabeshima CK,Caballero-Flores H,Cai S,Aranguren J,Borges Britto ML,Machado ME

    更新日期:2014-12-01 00:00:00

  • Effect of Liquid Platelet-rich Fibrin and Platelet-rich Plasma on the Regenerative Potential of Dental Pulp Cells Cultured under Inflammatory Conditions: A Comparative Analysis.

    abstract:INTRODUCTION:Platelet-rich plasma (PRP) has been widely used in regenerative dentistry for over 2 decades. Nevertheless, previous studies have shown that its growth factor content is released over a short time period, and the application of anticoagulants limits its regenerative potential. Therefore, a second-generatio...

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    journal_title:Journal of endodontics

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    authors: Jang Y,Hong HT,Roh BD,Chun HJ

    更新日期:2014-09-01 00:00:00

  • Adhesive dentistry and endodontics: materials, clinical strategies and procedures for restoration of access cavities: a review.

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    journal_title:Journal of endodontics

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    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Li R,Peng L,Ren L,Tan H,Ye L

    更新日期:2009-03-01 00:00:00

  • In vitro cytotoxicity evaluation of a novel root repair material.

    abstract:INTRODUCTION:This study examined the effect of a new bioactive dentin substitute material (Biodentine) on the viability of human gingival fibroblasts. METHODS:Biodentine, White ProRoot mineral trioxide aggregate (MTA), and glass ionomer cement were evaluated. Human gingival fibroblasts were incubated for 1, 3, and 7 d...

    journal_title:Journal of endodontics

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    authors: Zhou HM,Shen Y,Wang ZJ,Li L,Zheng YF,Häkkinen L,Haapasalo M

    更新日期:2013-04-01 00:00:00

  • Complement C3a Mobilizes Dental Pulp Stem Cells and Specifically Guides Pulp Fibroblast Recruitment.

    abstract:INTRODUCTION:Complement activation is considered a major mechanism in innate immunity. Although it is mainly involved in initiating inflammation, recent data reported its involvement in other processes such as tissue regeneration. In the dental pulp, complement C5a fragment has been shown to be involved in the recruitm...

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    authors: Rufas P,Jeanneau C,Rombouts C,Laurent P,About I

    更新日期:2016-09-01 00:00:00

  • Periapical biopsy report: an analysis of over a 10-year period.

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    pub_type: 杂志文章,评审


    authors: Spatafore CM,Griffin JA Jr,Keyes GG,Wearden S,Skidmore AE

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  • Effect of tissue fluids on hydrophobicity and adherence of Enterococcus faecalis to dentin.

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    journal_title:Journal of endodontics

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    authors: George S,Kishen A

    更新日期:2007-12-01 00:00:00

  • Pulpal Tissue Inflammatory Reactions after Experimental Pulpal Exposure in Mice.

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    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: He Y,Gan Y,Lu J,Feng Q,Wang H,Guan H,Jiang Q

    更新日期:2017-01-01 00:00:00

  • Influence of Atopy in the Outcome of Avulsed and Replanted Teeth during 5 Years of Follow-up.

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    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Roskamp L,Silva Neto UX,Carneiro E,Fariniuk LF,Westphalen VP

    更新日期:2017-01-01 00:00:00

  • Similar influence of stabilized alkaline and neutral sodium hypochlorite solutions on the fracture resistance of root canal-treated bovine teeth.

    abstract:INTRODUCTION:Stabilizing sodium hypochlorite (NaOCl) at an alkaline pH is proposed to increase solution stability and tissue dissolution ability; however, a reduction on the flexural strength of dentin discs has been found to be a side effect. This study sought to determine whether a stabilized alkaline NaOCl reduces t...

    journal_title:Journal of endodontics

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    authors: Souza EM,Calixto AM,Lima CN,Pappen FG,De-Deus G

    更新日期:2014-10-01 00:00:00

  • Orthodontic procedures after trauma.

    abstract::This review considers oral trauma and its relationship to orthodontics with respect to prevention and primary, secondary, and tertiary care. The level of evidence is not high in regard to this topic, but recommendable approaches to trauma at each stage are discussed on the basis of available literature and published g...

    journal_title:Journal of endodontics

    pub_type: 杂志文章,评审


    authors: Fields HW,Christensen JR

    更新日期:2013-03-01 00:00:00

  • Cytotoxic evaluation of root canal filling materials on primary human oral fibroblast cultures and a permanent hamster cell line.

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    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Tai KW,Huang FM,Chang YC

    更新日期:2001-09-01 00:00:00

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    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Gruendeman GW,Weine FS,Janik JM

    更新日期:1994-05-01 00:00:00

  • Cell Homing for Pulp Tissue Engineering with Endogenous Dentin Matrix Proteins.

    abstract:INTRODUCTION:Compelling evidence pinpoints that pulp tissue engineering after the transplantation of stem cells is possible. Although intriguing, severe problems regarding clinical feasibility remain. Cell homing has been proposed as a viable alternative in which dentin-derived growth factors in a conducive scaffold ma...

    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Widbiller M,Driesen RB,Eidt A,Lambrichts I,Hiller KA,Buchalla W,Schmalz G,Galler KM

    更新日期:2018-06-01 00:00:00

  • Effects of calcium silicate-based materials on collagen matrix integrity of mineralized dentin.

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    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Leiendecker AP,Qi YP,Sawyer AN,Niu LN,Agee KA,Loushine RJ,Weller RN,Pashley DH,Tay FR

    更新日期:2012-06-01 00:00:00

  • Effect of dynamic loading on the integrity of the interface between root canal and obturation materials.

    abstract::The purpose of this study was to evaluate the effect of occlusal load on the integrity of root canal obturation. Maxillary anterior teeth were cleaned, shaped, and obturated with either gutta-percha (GP)/AH Plus or Resilon/Epiphany. Afterwards, teeth were placed under 100 N force at 2 Hz for 22 hours in a 37 degrees C...

    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Bishop D,Griggs J,He J

    更新日期:2008-04-01 00:00:00