Abstract:
BACKGROUND:Autoimmune disorders are considered to be associated with a Th1 immune response while allergic diseases with a Th2 response. We carried out a study to determine whether there is an inverse relationship between allergic diseases in IgE-sensitized children or positive skin-prick test reactions to allergens and type 1 diabetes mellitus (DM1) in children. METHODS:Sixty-three children with DM1 and 108 controls were enrolled. Parents of all children compiled a questionnaire on allergic diseases. All children underwent skin-prick tests for common aero-allergens and food-allergens. RESULTS:A history of allergic symptoms, especially wheezing, asthma and allergic rhinitis was significantly less common in the group with DM1. Allergic symptoms in children with IgE sensitization or parental atopy were no more likely in children with DM1 than in normal control subjects. There was no association between skin-prick test results to inhalants and food allergens and DM1. CONCLUSIONS:Consistently with the Th1/Th2 paradigm, we observed a reduction in the frequency of allergic symptoms in children with DM1. However, our study did not succeed in demonstrating an inverse relation between Th1- and Th2-mediated diseases in children with IgE sensitization or an atopic genetic predisposition.
journal_name
Int Arch Allergy Immunoljournal_title
International archives of allergy and immunologyauthors
Caffarelli C,Cavagni G,Pierdomenico R,Chiari G,Spattini A,Vanelli Mdoi
10.1159/000079166keywords:
subject
Has Abstractpub_date
2004-08-01 00:00:00pages
288-94issue
4eissn
1018-2438issn
1423-0097pii
79166journal_volume
134pub_type
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