Abstract:
:A vexing difficulty of the RNA world hypothesis is how RNA molecules of significant complexity could ever have evolved given their susceptibility to degradation. One way degradation might have been reduced is through low temperature. Here we report that truncated and fragmented derivatives of the hairpin ribozyme can catalyze ligation of a wide variety of RNA molecules to a given sequence in frozen solution despite having little or no activity under standard solution conditions. These results suggest that complex RNAs could have evolved in freezing environments on the early earth and perhaps elsewhere.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Vlassov AV,Johnston BH,Landweber LF,Kazakov SAdoi
10.1093/nar/gkh601keywords:
subject
Has Abstractpub_date
2004-05-25 00:00:00pages
2966-74issue
9eissn
0305-1048issn
1362-4962pii
32/9/2966journal_volume
32pub_type
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