Abstract：
:In this study, we prepared DNA-lipid films and examined their intercalation behavior and tensile strength as an indicator for usefulness as a dental material. The lipids were synthesized from the reaction of glycine, l-alanine, or l-glutamic acid with n-alkyl alcohol in the presence of p-toluenesulfonic acid. The self-standing, water-insoluble DNA-lipid films were prepared by casting the DNA-lipid complex from chloroform/ethanol solution. The DNA-lipid films formed intercalation complexes with ethidium bromide. This indicates that DNA-lipid films maintain a double helical structure. The tensile strengths of DNA films were 0.8-2.4MPa and were compatible with a commercially available material (Membrane) for guided tissue regeneration in dental use. We conclude that DNA-lipid films have potential for use as a material for the surface treatment of implanted materials or as a bone-guiding scaffold for dental application.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Fukushima T,Hayakawa T,Inoue Y,Miyazaki K,Okahata Ydoi
10.1016/j.biomaterials.2004.01.006keywords:
subject
Has Abstractpub_date
2004-11-01 00:00:00pages
5491-7issue
24eissn
0142-9612issn
1878-5905pii
S0142961204000079journal_volume
25pub_type
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