Review of radiotherapy dose and volume for intracranial ependymoma.

Abstract:

BACKGROUND:Radiotherapy (RT) is well established in the management of intracranial ependymoma (EP) and post-operative RT is employed for the majority of patients. There are no randomised trials of RT in EP and evidence for dose and volume relies on retrospective single institution series, usually comprising a heterogeneous mix of relatively small numbers of patients recruited over several decades. PROCEDURE:The literature including RT dose and response data reported since the early 1990s was reviewed. RESULTS:Five-year overall survival (OS) ranges from 40 to 79%. There is some evidence of a dose response relationship from <45 Gy to >50 Gy. In the majority of series outcome is related to WHO grade and extent of resection. There is no evidence of benefit for 'prophylactic' craniospinal RT (CSRT). In all series there is a significant risk of local recurrence, usually within the target volume. Early results of conformal RT have suggested that a margin for CTV of 1 cm around the post-operative tumour bed and any residual GTV is feasible. CONCLUSIONS:The main aims of future studies will be to maximise the number of patients achieving complete resection, and RT dose escalation. Hyperfractionated radiotherapy (HFRT) has been employed in some studies and results are awaited. The role of CSRT needs to be evaluated further for patients presenting with leptomeningeal metastases. Multi-institutional and international studies are necessary to improve understanding of the clinical behaviour, biology and management of EP.

journal_name

Pediatr Blood Cancer

journal_title

Pediatric blood & cancer

authors

Taylor RE

doi

10.1002/pbc.10470

keywords:

subject

Has Abstract

pub_date

2004-05-01 00:00:00

pages

457-60

issue

5

eissn

1545-5009

issn

1545-5017

journal_volume

42

pub_type

杂志文章,评审
  • The duration of anthracycline infusion should be at least one hour in children with cancer: A clinical practice guideline.

    abstract::We aimed to provide recommendations on the infusion duration of anthracycline chemotherapy agents in children with cancer. This study also serves as a practice example of the essential steps that need to be taken when using a previously published systematic review to develop a high-quality clinical practice guideline....

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,实务指引,评审

    doi:10.1002/pbc.26867

    authors: Loeffen EAH,van Dalen EC,Mulder RL,van de Wetering MD,Kremer LCM,Tissing WJE,Anthracycline Cardiotoxicity Working Group.

    更新日期:2018-02-01 00:00:00

  • Communication, Documentation, and Training Standards in Pediatric Psychosocial Oncology.

    abstract::As part of a larger effort to create standards for psychosocial care of children with cancer, we document consensus and evidence-based data on interprofessional communication, documentation, and training for professionals providing psycho-oncology services. Six databases were searched. Sixty-five articles and six guid...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审

    doi:10.1002/pbc.25725

    authors: Patenaude AF,Pelletier W,Bingen K

    更新日期:2015-12-01 00:00:00

  • Higher plasma asparaginase activity after intramuscular than intravenous Erwinia asparaginase.

    abstract::It is unclear if dosing intervals for Erwinase can be extended with intramuscular (i.m.) versus intravenous (i.v.) dosing. Children with acute lymphoblastic leukemia received Erwinase at 30 000-42 000 IU/m2 i.v. or i.m. I.m. Erwinase (n = 22) achieved activity above 0.1 IU/mL for longer than i.v. Erwinase (n = 33) (3....

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.28244

    authors: Panetta JC,Liu Y,Swanson HD,Karol SE,Pui CH,Inaba H,Jeha S,Relling MV

    更新日期:2020-07-01 00:00:00

  • Salvage therapy for refractory hemophagocytic lymphohistiocytosis: A review of the published experience.

    abstract::Hemophagocytic lymphohistioytosis (HLH) is a severe, life-threatening hyperinflammatory disorder that requires prompt diagnosis and treatment. Approximately, 25-50% of patients with HLH fail to achieve remission with established regimens that include dexamethasone and etoposide, or methylprednisolone and antithymocyte...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审

    doi:10.1002/pbc.26308

    authors: Marsh RA,Jordan MB,Talano JA,Nichols KE,Kumar A,Naqvi A,Vaiselbuh SR,Histiocyte Society Salvage Therapy Working Group.

    更新日期:2017-04-01 00:00:00

  • Hypogammaglobulinemia in children after allogeneic hematopoietic stem cell transplantation: a cytokine mediated immunoglobulin isotype class switch arrest?

    abstract:BACKGROUND:Hypogammaglobulinemia (hypo-IgG) is common early post-HSCT in children, occasionally necessitating long-term immunoglobulin (Ig) G replacement therapy. IgG replacement may not reduce mortality, although infectious complications are decreased PROCEDURE:Clinical data and samples from 86 children were analyzed...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.25409

    authors: Sundin M,Remberger M,Lindqvist H,Omazic B,Sundberg B,Uzunel M,Winiarski J

    更新日期:2015-05-01 00:00:00

  • Growth hormone therapy for short stature in Diamond Blackfan anemia.

    abstract:BACKGROUND:We report a 13-year-old male with Diamond Blackfan anemia and short stature. He had a normal biochemical response to growth hormone (GH) stimulation, but his bone age was delayed, his insulin-like growth factor 1 (IGF-1) was low, and he had a poor growth velocity. He was started on daily GH injections. METH...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.20075

    authors: Scott EG,Haider A,Hord J

    更新日期:2004-10-01 00:00:00

  • Outcome of children with primary resistant or relapsed non-Hodgkin lymphoma and mature B-cell leukemia after intensive first-line treatment: a population-based analysis of the Austrian Cooperative Study Group.

    abstract:BACKGROUND:Children and adolescents with Non-Hodgkin lymphoma (NHL) and mature B-cell leukemia (B-ALL) have an excellent prognosis with contemporary chemotherapy stratified according to the histologic subtype and clinical stage of disease. However, a small subset of patients does not respond to front-line therapy or su...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/pbc.20121

    authors: Attarbaschi A,Dworzak M,Steiner M,Urban C,Fink FM,Reiter A,Gadner H,Mann G

    更新日期:2005-01-01 00:00:00

  • Acute lymphocytic leukemia in adolescence with multiple osteolytic lesions and hypercalcemia mediated by lymphoblast-producing parathyroid hormone-related peptide: a case report and review of the literature.

    abstract:BACKGROUND:Osteopathy is one of the common initial symptoms of acute lymphocytic leukemia (ALL) in children and adolescents, but multiple osteolysis accompanied by hypercalcemia is rarely observed. PROCEDURE:We treated a 14-year-old female who had multiple osteolytic lesions and hypercalcemia at initial onset of ALL. ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章,评审

    doi:10.1002/pbc.20357

    authors: Shimonodan H,Nagayama J,Nagatoshi Y,Hatanaka M,Takada A,Iguchi H,Oda Y,Okamura J

    更新日期:2005-09-01 00:00:00

  • Efficacy of surgery combined with postoperative 125 I interstitial brachytherapy for treatment of acinic cell carcinoma of the parotid gland in children and adolescents.

    abstract:BACKGROUND:Acinic cell carcinoma (AciCC) is rare in children; therefore, reaching a consensus on its management is challenging and radiotherapy is limited by concerns about long-term toxicity. The purpose of this study is to analyze the effectiveness and safety of surgery plus postoperative 125 I interstitial brachythe...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.28343

    authors: Li J,Zhang J,Lyu XM,Huang MW,Zheng L,Zhang JG

    更新日期:2020-07-01 00:00:00

  • Hepatoblastoma in a girl with biliary atresia: coincidence or co-incidence.

    abstract::Hepatoblastoma (HB) and biliary atresia (BA) are both rare conditions that occurred in the patient described. This is the second such case in the literature. An explanation for this apparent coincidence could possibly be found in the existance of pluripotent liver stem cells. In humans, small epithelial cells (SEC) be...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.20115

    authors: Taat F,Bosman DK,Aronson DC

    更新日期:2004-10-01 00:00:00

  • Clinicopathologic analysis of spindle cell/sclerosing rhabdomyosarcoma.

    abstract:BACKGROUND:Clinical characteristics and optimal treatment strategies for spindle cell/sclerosing rhabdomyosarcoma (ssRMS) have not been well established because of its rarity. PROCEDURE:Retrospective re-evaluation of sarcoma specimens (1997-2014) identified 16 ssRMSs (median age 20 years, range 7-39 years). Clinicopat...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.25367

    authors: Yasui N,Yoshida A,Kawamoto H,Yonemori K,Hosono A,Kawai A

    更新日期:2015-06-01 00:00:00

  • The influence of patient reported outcomes on the discussion of psychosocial issues in children with cancer.

    abstract:BACKGROUND:This study investigates the effect of using patient reported outcomes (PROs) about health-related quality of life (HRQOL) in clinical practice on the type and amount of psychosocial topics discussed during a paediatric oncology consultation. PROCEDURE:Children (N = 193) with cancer participated in a sequent...

    journal_title:Pediatric blood & cancer

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1002/pbc.24089

    authors: Engelen V,van Zwieten M,Koopman H,Detmar S,Caron H,Brons P,Egeler M,Kaspers GJ,Grootenhuis M

    更新日期:2012-07-15 00:00:00

  • Patient-reported health status during pediatric cancer treatment.

    abstract:BACKGROUND:Changes in patient function and factors affecting pediatric patients with cancer during treatment are largely unknown. The purpose of this study was to measure patient-reported outcomes (PROs) in children during the initial 6 months of therapy to characterize function and explore factors associated with func...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.26295

    authors: Dobrozsi S,Yan K,Hoffmann R,Panepinto J

    更新日期:2017-04-01 00:00:00

  • Prevalence of daily medication adherence among children with sickle cell disease: a 1-year retrospective cohort analysis.

    abstract::The objective of this study is to determine the prevalence of adherence to daily medications among children with sickle cell disease (SCD). Prescription records for 12 months were obtained from participants who had insurance in a Medicaid-based single health maintenance organization. Adherence was measured as a ratio ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.22605

    authors: Patel NG,Lindsey T,Strunk RC,DeBaun MR

    更新日期:2010-09-01 00:00:00

  • The role of the initial bone marrow aspirate in the diagnosis of hemophagocytic lymphohistiocytosis.

    abstract:BACKGROUND:The identification of hemophagocytosis (HPC) in tissue or bone marrow (BM) represents only one of 5/8 criteria needed for the diagnosis of hemophagocytic lymphohistiocytosis (HLH). Yet, confirmation of HPC in bone marrow aspirates (BMA) is often relied upon to make therapeutic decisions. There is no standard...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.21564

    authors: Gupta A,Tyrrell P,Valani R,Benseler S,Weitzman S,Abdelhaleem M

    更新日期:2008-09-01 00:00:00

  • Fournier's gangrene and scrotal ulcerations during all-trans-retinoic acid therapy for acute promyelocytic leukemia.

    abstract::Scrotal ulcers are a rare manifestation in patients with acute promyelocytic leukemia. Fournier's gangrene (FG) is even rarer. We describe three adolescents and young adults who developed scrotal ulcerations during induction with all-trans-retinoic acid. One patient developed FG. These lesions are predominantly seen i...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.21549

    authors: Naithani R,Kumar R,Mahapatra M

    更新日期:2008-08-01 00:00:00

  • EBV lymphoproliferative disease of host origin after haploidentical stem cell transplantation.

    abstract::Post-transplant lymphoproliferative disease (PTLPD), due to the reactivation of Epstein-Barr virus (EBV), is a serious complication. The risk of the disorder increases with T-cell depletion methods, mismatched hematopoietic stem cell transplantation (HSCT), graft-versus-host disease (GVHD), and immunosuppression. In c...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.20710

    authors: Kasow KA,Leung W,Horwitz EM,Woodard P,Handgretinger R,Hale GA

    更新日期:2007-11-01 00:00:00

  • Practice patterns and recommendations for pediatric image-guided radiotherapy: A Children's Oncology Group report.

    abstract::This report by the Radiation Oncology Discipline of Children's Oncology Group (COG) describes the practice patterns of pediatric image-guided radiotherapy (IGRT) based on a member survey and provides practice recommendations accordingly. The survey comprised of 11 vignettes asking clinicians about their recommended tr...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.28629

    authors: Hua CH,Vern-Gross TZ,Hess CB,Olch AJ,Alaei P,Sathiaseelan V,Deng J,Ulin K,Laurie F,Gopalakrishnan M,Esiashvili N,Wolden SL,Krasin MJ,Merchant TE,Donaldson SS,FitzGerald TJ,Constine LS,Hodgson DC,Haas-Kogan DA,Mahaja

    更新日期:2020-10-01 00:00:00

  • Quality of life in childhood immune thrombocytopenia: international validation of the kids' ITP tools.

    abstract:BACKGROUND:The Kids ITP Tools (KIT) is a disease-specific measure of health-related quality of life for children with immune thrombocytopenia (ITP). To facilitate use in international trials it has been cross-culturally adapted for France, Germany, the United Kingdom and Uruguay. This study assessed the validity and re...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.24257

    authors: Klaassen RJ,Blanchette V,Burke TA,Wakefield C,Grainger JD,Gaedicke G,Riedlinger A,Dufort G,Citrin E,Reguerre Y,Pellier I,Curtis C,Young NL

    更新日期:2013-01-01 00:00:00

  • Ewing sarcoma/primitive neuroectodermal tumor of the kidney in a child.

    abstract::A 6-year-old female was admitted with abdominal pain and a mass in the right abdomen. Her lactose dehydrogenase level was 1,200 IU/L, and neuron specific enolase was 120 ng/ml. Computed tomography scan confirmed a large right renal mass with necrosis. A right radical nephrectomy was performed. The tumor was completely...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.20831

    authors: Maeda M,Tsuda A,Yamanishi S,Uchikoba Y,Fukunaga Y,Okita H,Hata J

    更新日期:2008-01-01 00:00:00

  • Extramedullary infiltration at diagnosis and prognosis in children with acute myelogenous leukemia.

    abstract:BACKGROUND:Extramedullary infiltration (EMI) is an occasional clinical symptom in childhood acute myelogenous leukemia (AML), but there is considerable controversy regarding the prognostic significance of EMI in AML. PROCEDURE:We evaluated the frequency and prognostic significance of EMI at diagnosis of AML in childre...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.20824

    authors: Kobayashi R,Tawa A,Hanada R,Horibe K,Tsuchida M,Tsukimoto I,Japanese childhood AML cooperative study group.

    更新日期:2007-04-01 00:00:00

  • Tumor cells are present in stem cell harvests of Ewings sarcoma patients and their persistence following transplantation is associated with relapse.

    abstract:BACKGROUND:Tumor cells frequently contaminate autologous stem cell products in a variety of malignancies, but their clinical significance remains controversial. We retrospectively monitored tumor contamination in stem cell harvests from patients with Ewing family of tumors (EFT) all harboring the specific translocation...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.20022

    authors: Yaniv I,Cohen IJ,Stein J,Zilberstein J,Liberzon E,Atlas O,Grunshpan A,Sverdlov Y,Ash S,Zaizov R,Avigad S

    更新日期:2004-05-01 00:00:00

  • Sequential administration of methotrexate and asparaginase in relapsed or refractory pediatric acute myeloid leukemia.

    abstract:BACKGROUND:The efficacy of combination chemotherapy with methotrexate (MTX) and asparaginase is not well known in relapsed and refractory acute leukemia after contemporary therapy. PROCEDURE:A retrospective study of pediatric patients with relapsed or refractory acute myeloid leukemia (AML) who received MTX and aspara...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.24470

    authors: Buaboonnam J,Cao X,Pauley JL,Pui CH,Ribeiro RC,Rubnitz JE,Inaba H

    更新日期:2013-07-01 00:00:00

  • Prolactinoma as the first manifestation of Gardner's syndrome.

    abstract::Familial adenomatous polyposis (FAP) is an inherited condition causing numerous adenomatous colorectal polyps and a markedly elevated risk of colon cancer. FAP may be associated with various extracolonic manifestations such as desmoid fibromatosis and osteomas (termed Gardner's syndrome) and brain tumors, usually medu...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.20985

    authors: Goodin GS,McCarville MB,Thibodeau SN,Skapek SX,Khoury JD,Spunt SL

    更新日期:2008-02-01 00:00:00

  • Eutectic mixture of lidocaine and prilocaine versus 1% lidocaine injection for lumbar punctures in pediatric oncology patients.

    abstract:BACKGROUND:The role of local analgesics for lumbar punctures (LPs) in pediatric oncology patients has not been specifically studied. AIM:To compare the efficacy of eutectic mixture of local anesthetics (EMLA) cream to 1% lidocaine injection for LPs. METHOD:This was a retrospective observational study of all patients ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.27957

    authors: Cruickshank A,Qeadan F,Kuttesch JF,Agarwal HS

    更新日期:2019-11-01 00:00:00

  • The Saint Siluan warning signs of cancer in children: impact of education in rural South Africa.

    abstract::Two thirds of children with cancer never reach a specialist centre for treatment in South Africa. The majority of those who present have advanced disease. A campaign was undertaken to educate the public and the primary health workers on the Saint Siluan early warning signs of cancer in children. There was a statistica...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.22853

    authors: Poyiadjis S,Wainwright L,Naidu G,Mackinnon D,Poole J

    更新日期:2011-02-01 00:00:00

  • High burden of metastases and poor outcome in pelvic PNET.

    abstract::Data on prognostic factors in pelvic PNET are minimal. We analyzed patients with pelvic PNET treated between June 2003 and November 2011 for prognostic factors. Forty-eight (13%) of 374 patients with PNET were pelvic PNET with median age 14.5 years (range: 5-33); 31 (65%) had metastases. After median follow-up of 20.4...

    journal_title:Pediatric blood & cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/pbc.24552

    authors: Biswas B,Agarwala S,Rastogi S,Khan SA,Mohanti BK,Sharma DN,Pathy S,Bakhshi S

    更新日期:2013-09-01 00:00:00

  • A new clinical score for disease activity in Langerhans cell histiocytosis.

    abstract:OBJECTIVE:To develop an objective tool for assessing disease activity in patients with Langerhans cell histiocytosis (LCH). METHOD:Scoring system was developed and applied to a database containing information on 612 patients. RESULTS:At diagnosis, the score distribution was highly asymmetrical: the score was between ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.20160

    authors: Donadieu J,Piguet C,Bernard F,Barkaoui M,Ouache M,Bertrand Y,Ibrahim H,Emile JF,Hermine O,Tazi A,Genereau T,Thomas C

    更新日期:2004-12-01 00:00:00

  • Proper use of social media by health operators in the pediatric oncohematological setting: Consensus statement from the Italian Pediatric Hematology and Oncology Association (AIEOP).

    abstract::Social media are powerful means of communication that can also have an important role in the healthcare sector. They are sometimes seen with diffidence in the healthcare setting, partly because they risk blurring professional boundaries. This issue is particularly relevant to relations between caregivers and adolescen...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.26958

    authors: Clerici CA,Quarello P,Bergadano A,Veneroni L,Bertolotti M,Guadagna P,Ricci A,Galdi A,Fagioli F,Ferrari A

    更新日期:2018-05-01 00:00:00

  • Stereotactic body radiotherapy for pediatric hepatocellular carcinoma with central biliary obstruction.

    abstract::Here, we present the case of a pediatric patient with newly diagnosed hepatocellular carcinoma causing central biliary obstruction and persistently elevated bilirubin of 3.0-4.3 mg/dl despite placement of bilateral internal-external biliary drains. The tumor was not resectable, and the patient was not a candidate for ...

    journal_title:Pediatric blood & cancer

    pub_type: 杂志文章

    doi:10.1002/pbc.26330

    authors: Hiniker SM,Rangaswami A,Lungren MP,Thakor AS,Concepcion W,Balazy KE,Kovalchuk N,Donaldson SS

    更新日期:2017-06-01 00:00:00