Spatial memory retention is enhanced by acute and continuous estradiol replacement.

Abstract:

:Estradiol replacement to ovariectomized female rats causes dramatic changes in hippocampal structure and function as well as in performance on hippocampally dependent tasks. Using a delayed matching-to-place version of the water maze, the present study examines the time course of estradiol-induced enhancements in memory retention as well as the effectiveness of acute and continuous patterns of replacement. One 10-microg injection of estradiol administered on each of two successive days resulted in significant improvements in memory retention that persisted for approximately 4 days following the second injection. When estradiol administration continued for 10 consecutive days, these improvements in memory retention persisted. These findings indicate that estradiol replacement can improve memory retention and that these improvements can be maintained by continuous replacement for at least 10 days.

journal_name

Horm Behav

journal_title

Hormones and behavior

authors

Sandstrom NJ,Williams CL

doi

10.1016/j.yhbeh.2003.09.010

keywords:

subject

Has Abstract

pub_date

2004-02-01 00:00:00

pages

128-35

issue

2

eissn

0018-506X

issn

1095-6867

pii

S0018506X0300237X

journal_volume

45

pub_type

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