Optokinetic nystagmus in strabismus: are asymmetries related to binocularity?

abstract：PURPOSE:To assess the repeatability and interoperator and intersession reproducibility of central corneal thickness (CCT) measurements made by a commercially available optical coherence tomography (OCT) system. METHODS:Intersession and interoperator reproducibility and repeatability were defined according to the guide...

journal_title：Investigative ophthalmology & visual science

authors： Muscat S,McKay N,Parks S,Kemp E,Keating D

更新日期：2002-06-01 00:00:00

abstract：:In vivo conjunctival epithelial healing in albino rabbits was investigated by light microscopy following both n-heptanol and trephined conjunctival wounding. Reepithelialization occurred faster following n-heptanol treatment (3 days) versus trephination (6-7 days). No goblet cells were present in the migrating epithel...

journal_title：Investigative ophthalmology & visual science

authors： Geggel HS,Friend J,Thoft RA

更新日期：1984-07-01 00:00:00

abstract：PURPOSE:To localize and identify the gene and mutations causing autosomal recessive retinitis pigmentosa in three consanguineous Pakistani families. METHODS:Blood samples were collected and DNA was extracted. A genome-wide scan was performed by using 382 polymorphic microsatellite markers on genomic DNA from affected ...

journal_title：Investigative ophthalmology & visual science

authors： Riazuddin SA,Zulfiqar F,Zhang Q,Sergeev YV,Qazi ZA,Husnain T,Caruso R,Riazuddin S,Sieving PA,Hejtmancik JF

更新日期：2005-07-01 00:00:00

abstract：PURPOSE:To test the hypothesis that the robust expansion of bovine corneal endothelial cells (BCECs) in vitro is due to the presence of individual endothelial cells with various levels of proliferative potential. METHODS:BCECs and bovine vascular endothelial cells (ECs) derived from aorta, coronary artery, and pulmona...

journal_title：Investigative ophthalmology & visual science

authors： Huang L,Harkenrider M,Thompson M,Zeng P,Tanaka H,Gilley D,Ingram DA,Bonanno JA,Yoder MC

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:To determine the role of connexin43 (Cx43) and gap junctional intercellular communication (GJIC) in the response of the human retinal pigment epithelial cell line ARPE-19 to oxidative stress. METHODS:ARPE-19 cells were treated with the chemical oxidant tert-butyl hydroperoxide (t-BOOH), and cell viability was ...

journal_title：Investigative ophthalmology & visual science

authors： Hutnik CM,Pocrnich CE,Liu H,Laird DW,Shao Q

更新日期：2008-02-01 00:00:00

abstract：:Vitreous and macrophage samples were tested for the ability to stimulate proliferation and cell migration in cultured rabbit retinal pigment epithelium (RPE). A macrophage invasion was elicited by the intravitreal injection of latex particles in rabbits and after 3 days the vitreal macrophages were collected. The macr...

journal_title：Investigative ophthalmology & visual science

authors： Burke JM,Twining SS

更新日期：1987-07-01 00:00:00

abstract：Purpose:We compare the choroidal vascular area between Bietti crystalline dystrophy (BCD) patients with CYP4V2 mutations, retinitis pigmentosa (RP) patients with EYS mutations, and normal controls, and investigate the correlation between choroidal vascular area and associated parameters. Methods:This prospective case-...

journal_title：Investigative ophthalmology & visual science

authors： Hirashima T,Miyata M,Ishihara K,Hasegawa T,Sugahara M,Ogino K,Yoshikawa M,Hata M,Kuroda Y,Muraoka Y,Ooto S,Yoshimura N

更新日期：2017-08-01 00:00:00

abstract：Purpose:Neuroretinopathy is increasingly being recognized as an independent cause of vision loss in diabetes. Visual field loss, as detected by frequency doubling technology (FDT)-based visual perimetry, is a sign of neuroretinopathy and occurs in early stages of diabetic retinopathy (DR). Here, we hypothesized that FD...

journal_title：Investigative ophthalmology & visual science

authors： Bao YK,Yan Y,Gordon M,McGill JB,Kass M,Rajagopal R

更新日期：2019-11-01 00:00:00

abstract：PURPOSE:Metabolism and transport of cysteine are critical for maintenance of the intracellular glutathione (GSH) level. In this study, transport mechanisms of L-cystine and regulation of GSH biosynthesis in the absence or presence of NO-induced oxidant stress were investigated in primary cultured rabbit conjunctival ep...

journal_title：Investigative ophthalmology & visual science

authors： Gukasyan HJ,Kannan R,Lee VH,Kim KJ

更新日期：2003-03-01 00:00:00

abstract：PURPOSE:Ligands for aryl hydrocarbon receptor (AHR), such as dioxins, are highly toxic. One such ligand, TCDD, was found to exert potent immunosuppressive capacities in mice developing pathogenic autoimmune processes, including EAU, but its toxicity makes it unusable for humans. A recently identified endogenous AHR lig...

journal_title：Investigative ophthalmology & visual science

authors： Nugent LF,Shi G,Vistica BP,Ogbeifun O,Hinshaw SJ,Gery I

更新日期：2013-11-13 00:00:00

abstract：:Rabbit corneas were treated in vitro and in vivo with cholera toxin (CTX), a specific and irreversible activator of adenylate cyclase. Tissue pieces incubated in vitro in the presence of 10 mug/ml CTX for 15 min continuously synthesized adenosine 3',5'-monophosphate (cyclic AMP) at an increased rate for 3 hr in the ab...

journal_title：Investigative ophthalmology & visual science

authors： Jumblatt MM,Fogle JA,Neufeld AH

更新日期：1980-11-01 00:00:00

abstract：:The authors investigated the mechanisms underlying the head shaking shown by some patients with congenital nystagmus (CN). In order to improve visual function by head shaking, a patient with CN must have some visual acuity loss due to retinal image motion created by the nystagmus; an abnormal vestibulo-ocular reflex (...

journal_title：Investigative ophthalmology & visual science

authors： Carl JR,Optican LM,Chu FC,Zee DS

更新日期：1985-08-01 00:00:00

abstract：PURPOSE:Glaucomatous optic neuropathy is characterized by remodeling of the extracellular matrix with disorganization of elastic fibers in the optic nerve head (ONH). There are significant differences in prevalence of glaucomatous optic neuropathy between African Americans (AAs) and Caucasian Americans (CAs). The goal ...

journal_title：Investigative ophthalmology & visual science

authors： Urban Z,Agapova O,Hucthagowder V,Yang P,Starcher BC,Hernandez MR

更新日期：2007-07-01 00:00:00

abstract：PURPOSE:To study reading acuity in children and assess the reliability of its measurement using the Italian version of the MNREAD reading chart. METHODS:One hundred sixteen children from grades 3 to 8 with normal near vision were tested at a pediatric eye care institution in northeastern Italy. Visual acuity was evalu...

journal_title：Investigative ophthalmology & visual science

authors： Virgili G,Cordaro C,Bigoni A,Crovato S,Cecchini P,Menchini U

更新日期：2004-09-01 00:00:00

abstract：PURPOSE:Intrastromal inlays for refractive correction of presbyopia are being adopted into clinical practice. An important concern is the effect of the inlay on the long-term health of the cornea due to disturbances in the concentration profiles of metabolic species. A three-dimensional metabolic model for the cornea i...

journal_title：Investigative ophthalmology & visual science

authors： Pinsky PM

更新日期：2014-05-15 00:00:00

abstract：:We have investigated alterations of the metabolic state in vitamin A-deficient (A-) corneas using phosphorus-31 (31P) nuclear magnetic resonance (NMR) spectroscopy. Comparing to the control, A- corneas showed a prominent rise of phosphocreatine (PCr) as well as a total loss of glycerophosphorylcholine (GPC). Further, ...

journal_title：Investigative ophthalmology & visual science

authors： Hayashi K,Cheng HM,Xiong J,Xiong H,Kenyon KR

更新日期：1989-04-01 00:00:00

abstract：:The peroxidase-antiperoxidase method was used to study ten surgically obtained human optic nerve gliomas (pilocytic astrocytomas). All tissues were formalin fixed and paraffin embedded. Primary antisera included glial fibrillary acidic protein (GFAP), HNK-1 (type 1 astrocyte precursor marker), A2B5 (type 2 astrocyte p...

journal_title：Investigative ophthalmology & visual science

authors： Cutarelli PE,Roessmann UR,Miller RH,Specht CS,Grossniklaus HE

更新日期：1991-08-01 00:00:00

abstract：PURPOSE:To quantify the prevalence and effect on visual acuity of macular cysts in a large cohort of patients with retinitis pigmentosa. METHODS:In 316 patients with typical forms of retinitis pigmentosa, visual acuity was measured with Early Treatment Diabetic Retinopathy Study (ETDRS) charts, macular cysts were dete...

journal_title：Investigative ophthalmology & visual science

authors： Sandberg MA,Brockhurst RJ,Gaudio AR,Berson EL

更新日期：2008-10-01 00:00:00

abstract：PURPOSE:To determine whether intraocular pressure (IOP) elevation alters OPA1 expression and triggers OPA1 release, as well as whether the uncompetitive N-methyl-d-aspartate (NMDA) glutamate receptor antagonist memantine blocks OPA1 release and subsequent apoptotic cell death in glaucomatous DBA/2J mouse retina. METHO...

journal_title：Investigative ophthalmology & visual science

authors： Ju WK,Kim KY,Angert M,Duong-Polk KX,Lindsey JD,Ellisman MH,Weinreb RN

更新日期：2009-02-01 00:00:00

abstract：PURPOSE:To better understand ocular hypertension-induced early molecular alterations that may determine the initiation of neurodegeneration in human glaucoma, this study analyzed retinal proteomic alterations in the ocular hypertensive human retina. METHODS:Retina samples were obtained from six human donors with ocula...

journal_title：Investigative ophthalmology & visual science

authors： Yang X,Hondur G,Li M,Cai J,Klein JB,Kuehn MH,Tezel G

更新日期：2015-09-01 00:00:00

abstract：Purpose:Despite the potential for adaptive optics scanning light ophthalmoscopy (AOSLO) to quantify retinal disease progression at the cellular level, there remain few longitudinal studies investigating changes in cone density as a measure of disease progression. Here, we undertook a prospective, longitudinal study to ...

journal_title：Investigative ophthalmology & visual science

authors： Jackson K,Vergilio GK,Cooper RF,Ying GS,Morgan JIW

更新日期：2019-04-01 00:00:00

abstract：:Substance P (SP)--like immunoreactivity has been localized to distinct retinal cell populations in the primate Macaca nemestrina by means of immunohistochemical techniques with a well-characterized monoclonal antiserum directed to SP. The specificity of the immunoreactive staining was established by absorption of the ...

journal_title：Investigative ophthalmology & visual science

authors： Brecha N,Hendrickson A,Florén I,Karten HJ

更新日期：1982-08-01 00:00:00

abstract：PURPOSE:To investigate the effect of corneal trauma on gene expression in the lacrimal gland and to assess how many genes and what specific genes are regulated in response to corneal trauma. METHODS:A mouse model with acute corneal trauma was created with a chemical burn to the cornea with silver nitrate. Sixty-four f...

journal_title：Investigative ophthalmology & visual science

authors： Fang Y,Choi D,Searles RP,Mathers WD

更新日期：2005-02-01 00:00:00

abstract：PURPOSE:Fibroblast growth factor-10 (FGF10) can modulate extracellular matrix associated genes and, therefore, it could be a myopia susceptibility gene. This study used an animal model, single nucleotide polymorphisms (SNPs) association, and genetic functional assay to evaluate FGF10 gene for myopia. METHODS:The expre...

journal_title：Investigative ophthalmology & visual science

authors： Hsi E,Chen KC,Chang WS,Yu ML,Liang CL,Juo SH

更新日期：2013-05-07 00:00:00

abstract：PURPOSE:We examined changes of the central nervous system in patients with advanced primary open-angle glaucoma (POAG). METHODS:The clinical observational study included 15 patients with bilateral advanced POAG and 15 healthy normal control subjects, matched for age and sex with the study group. Retinal nerve fiber l...

journal_title：Investigative ophthalmology & visual science

authors： Chen WW,Wang N,Cai S,Fang Z,Yu M,Wu Q,Tang L,Guo B,Feng Y,Jonas JB,Chen X,Liu X,Gong Q

更新日期：2013-01-17 00:00:00

abstract：PURPOSE:To validate velocity measurements produced by spectral domain optical coherence tomography (SD-OCT) in an in vitro laminar flow model. METHODS:A 30-mL syringe filled with skim milk was inserted into a syringe pump. Intravenous (i.v.) tubing connected the syringe within the pump to a glass capillary tube (inter...

journal_title：Investigative ophthalmology & visual science

authors： Kagemann L,Wollstein G,Ishikawa H,Townsend KA,Schuman JS

更新日期：2009-02-01 00:00:00

abstract：PURPOSE:To reconstruct the role played by vascular endothelium in the elevation of circulating von Willebrand factor (vWf) in diabetic patients with microangiopathy and, specifically, to determine whether storage and synthesis of vWf is altered in diabetic retinal vessels. METHODS:Trypsin digests were prepared from re...

journal_title：Investigative ophthalmology & visual science

authors： Boeri D,Cagliero E,Podestá F,Lorenzi M

更新日期：1994-02-01 00:00:00

abstract：Purpose:Retinal nonperfusion and hypoxia are important factors in human diabetic retinopathy, and these presumably inhibit energy production and lead to cell death. The purpose of this study was to elucidate the effect of diabetes on inner retinal oxygen delivery and metabolism in a mouse model of diabetes. Methods:Ph...

journal_title：Investigative ophthalmology & visual science

authors： Blair NP,Wanek J,Felder AE,Brewer KC,Joslin CE,Shahidi M

更新日期：2016-11-01 00:00:00

abstract：PURPOSE:Overloading of unfolded or misfolded proteins in the endoplasmic reticulum (ER) can cause ER stress and activate the unfolded protein response (UPR) in the cell. The authors tested whether transgene overexpression in the mouse lens would activate the UPR. METHODS:Transgenic mice expressing proteins that either...

journal_title：Investigative ophthalmology & visual science

authors： Reneker LW,Chen H,Overbeek PA

更新日期：2011-04-04 00:00:00

abstract：PURPOSE:Adult salamander photoreceptors retract existing axons and extend new neuritic processes in vitro. In mammalian retina, similar forms of structural plasticity occur in injury and disease. The authors asked whether RhoA is present in photoreceptor axon terminals and whether activity in the RhoA-ROCK pathway cont...

journal_title：Investigative ophthalmology & visual science

authors： Fontainhas AM,Townes-Anderson E

更新日期：2008-09-01 00:00:00