Abstract：
:An A --> G single nucleotide polymorphism (SNP) at nucleotide 153,104 in the retinoblastoma susceptibility locus (RB1) at 13q14 was previously reported to be present only in Asians. In this study, we determined the distribution of this SNP in normal Southeast Asian populations (Chinese, Malay, Javanese, Thai, Filipino), in South Asian populations (Bangladeshi, Pakistani Pushtun and Indian) and in Chinese retinoblastoma cases and control subjects. The RB1 SNP was present in all populations at an overall frequency of =/< 0.18. Heterozygosity was higher in the Southeast Asian groups (0.14-0.34) than in the South Asian groups (Bangladeshi and Indian) (0.04-0.06). Significant differences in allele frequencies were found between the two population groups. Interestingly, our Pakistani population comprised of ethnic Pushtuns from northwest Pakistan was significantly different from the neighbouring Bangladeshi and Indian populations. No significant difference was found between Chinese case patients and control subjects. This RB1 SNP appears to be an ethnic variant prevalent in Southeast Asian populations and may be useful for studying RB1 inheritance by pedigree analysis.
journal_name
J Genetjournal_title
Journal of geneticsauthors
Kadam-Pai P,Su XY,Miranda JJ,Soemantri A,Saha N,Heng CK,Lai PSdoi
10.1007/BF02715879keywords:
subject
Has Abstractpub_date
2003-04-01 00:00:00pages
33-7issue
1-2eissn
0022-1333issn
0973-7731journal_volume
82pub_type
杂志文章abstract：:Both cowpea and yard-long bean belong to Vigna unguiculata ssp. unguiculata but have diverged through human induced evolution in sub-Saharan Africa and Asia, respectively. To map the quantitative trait loci (QTLs) for yield associated traits and derive new lines that may combine the attributes of both types, we develo...
journal_title：Journal of genetics
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journal_title：Journal of genetics
pub_type： 杂志文章,meta分析,评审
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journal_title：Journal of genetics
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更新日期：2018-08-24 00:00:00
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journal_title：Journal of genetics
pub_type： 杂志文章
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更新日期：2001-12-01 00:00:00
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journal_title：Journal of genetics
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pub_type： 杂志文章
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更新日期：2019-03-01 00:00:00
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更新日期：2018-03-01 00:00:00
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journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-009-0030-1
更新日期：2009-08-01 00:00:00
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journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2019-06-01 00:00:00
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journal_title：Journal of genetics
pub_type： 杂志文章
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更新日期：2020-01-01 00:00:00
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journal_title：Journal of genetics
pub_type： 杂志文章
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更新日期：2017-03-01 00:00:00
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journal_title：Journal of genetics
pub_type： 杂志文章,meta分析
doi：
更新日期：2019-06-01 00:00:00
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journal_title：Journal of genetics
pub_type： 杂志文章
doi：
更新日期：2020-01-01 00:00:00
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journal_title：Journal of genetics
pub_type： 杂志文章
doi：10.1007/s12041-008-0063-x
更新日期：2008-12-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1007/s12041-008-0074-7
更新日期：2008-12-01 00:00:00
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journal_title：Journal of genetics
pub_type： 杂志文章
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更新日期：2017-09-01 00:00:00
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journal_title：Journal of genetics
pub_type： 杂志文章
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更新日期：2011-04-01 00:00:00
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pub_type： 历史文章,杂志文章,评审
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Journal of genetics
pub_type： 杂志文章
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更新日期：2007-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2015-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2018-03-01 00:00:00
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journal_title：Journal of genetics
pub_type： 杂志文章
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更新日期：2019-06-01 00:00:00
