Abstract:
:Platelets activated with physiological agonists, such as thrombin, ADP, or collagen, released products able to modulate neutrophil functions. In particular, platelet supernatant contained an inhibitor of superoxide anion generation induced by phorbol ester and a chemotactic factor for human neutrophils. The proteolytic digestion of platelet supernatant completely abrogated chemotactic activity without interfering with the inhibitory effect, indicating the presence of different molecules involved in the modulation of different neutrophil functions. This was further confirmed by the pretreatment of platelets with aromatic benzamidine which abolished chemotactic activity, but did not affect superoxide inhibition of neutrophils. This report provides evidence for interaction of platelets and inflammatory cells, suggesting that platelets are able to induce accumulation of neutrophils and control their respiratory burst, which also has a critical role in tissue damaging in inflammation.
journal_name
Inflammationjournal_title
Inflammationauthors
Spisani S,Giuliani AL,Cavalletti T,Zaccarini M,Milani L,Gavioli R,Traniello Sdoi
10.1007/BF00918954keywords:
subject
Has Abstractpub_date
1992-04-01 00:00:00pages
147-58issue
2eissn
0360-3997issn
1573-2576journal_volume
16pub_type
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