Abstract：
:Circulating antibodies specific to retinal proteins have been associated with retinal dysfunction in patients with retinopathy. Anti-recoverin antibodies found in patients with cancer-associated retinopathy (CAR) represent a unique model to study the relationship between retinal degeneration and autoimmunity. A body of evidence from in vitro and in vivo studies indicates that anti-recoverin autoantibodies are cytotoxic to retinal cells and induce apoptotic death of retinal photoreceptor cells, which leads to the degeneration of the photoreceptor cell layer. Similar to anti-recoverin autoantibodies, antibodies with other retinal specificities induce their target retinal cell death by activating a caspase 3-dependent apoptotic pathway. Thus, autoantibody-induced apoptosis may be a common pathway that leads to retinal death and blindness.
journal_name
Autoimmun Revjournal_title
Autoimmunity reviewsauthors
Adamus Gdoi
10.1016/s1568-9972(02)00127-1keywords:
subject
Has Abstractpub_date
2003-03-01 00:00:00pages
63-8issue
2eissn
1568-9972issn
1873-0183pii
S1568997202001271journal_volume
2pub_type
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journal_title：Autoimmunity reviews
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journal_title：Autoimmunity reviews
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