Abstract：
:Primary biliary cirrhosis (PBC) has been coined a model autoimmune disease. In fact, it does share many similarities with other autoimmune diseases, but there are striking differences that illustrate the uniqueness of the immunopathology. Firstly, similar to other autoimmune diseases, there is an intense humoral and cellular response to an intracytoplasmic antigen. There is also an overlap of the epitopes recognized by autoreactive CD4(+), CD8(+) T cells as well as B cells. Patients with PBC are also predominantly female, and there is a higher family history of other autoimmune diseases. In contrast, however, there are no specific HLA associations in PBC. Further, there are no spontaneous or induced animal models of PBC. In addition, early in the biliary lesions of PBC, there is an eosinophilic infiltration and, often, there are granulomas. Finally, unlike several other human autoimmune diseases, patients with PBC have recognition of but one major epitope, and there is no evidence for determinant spreading. Hence, although the immune response of PBC has been vigorously defined, there remain major gaps in understanding the most difficult issue of all, namely etiology.
journal_name
Autoimmun Revjournal_title
Autoimmunity reviewsauthors
Ichiki Y,Shimoda S,Ishibashi H,Gershwin MEdoi
10.1016/j.autrev.2004.04.001keywords:
subject
Has Abstractpub_date
2004-06-01 00:00:00pages
331-6issue
4eissn
1568-9972issn
1873-0183pii
S1568997204000576journal_volume
3pub_type
杂志文章,评审abstract：:Henoch-Schönlein purpura is the most common systemic vasculitis in childhood, characterized by the presence of immunoglobulin A deposits in the small vessels of skin, gastrointestinal tube, joints and kidneys. Although there have been great efforts made in elucidating its pathogenic mechanisms, Henoch-Schönlein purpur...
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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更新日期：2008-12-01 00:00:00
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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更新日期：2008-10-01 00:00:00
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,评审
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更新日期：2007-06-01 00:00:00
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journal_title：Autoimmunity reviews
pub_type： 杂志文章,meta分析
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更新日期：2019-02-01 00:00:00
abstract：:Musculoskeletal (MSK) disorders constitute one of the most common clinical presentations to clinical care givers. Within this category of illnesses, systemic autoimmune rheumatic diseases (SARD) such as systemic lupus erythematosus (SLE), systemic sclerosis (SSc), Sjögren's syndrome (SjS) and rheumatoid arthritis (RA)...
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pub_type： 杂志文章,评审
doi：10.1016/j.autrev.2007.08.003
更新日期：2007-11-01 00:00:00
