Abstract：
:Dermatomyositis (DM), polymyositis (PM), and sporadic inclusion-body myositis (sIBM) constitute a heterogeneous group of subacute or chronic acquired skeletal muscle diseases. Known as idiopathic inflammatory myopathies (IIM), they all share the presence of considerable weakness due to muscle inflammation and necrosis. Diagnosis is based on clinical findings, confirmed by laboratory examinations (serum muscle enzyme concentrations, autoantibodies against nuclear or cytoplasmatic antigens, electromyography, and muscle biopsy). Environmental exposures leading to immune activation in genetically susceptible individuals seem to be a probable pathogenic mechanism. Infectious agents, drugs, and ultraviolet radiation have been identified as a cause of the onset, exacerbation, or acceleration of these myopathies. Several case reports and population studies have been reported to support the relationship between inflammatory myopathy and the environment. Moreover, seasonal patterns of the onset of IIM have frequently been reported.
journal_name
Autoimmun Revjournal_title
Autoimmunity reviewsauthors
Prieto S,Grau JMdoi
10.1016/j.autrev.2009.11.006subject
Has Abstractpub_date
2010-03-01 00:00:00pages
A330-4issue
5eissn
1568-9972issn
1873-0183pii
S1568-9972(09)00184-0journal_volume
9pub_type
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更新日期：2014-08-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1016/j.autrev.2008.11.006
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pub_type： 杂志文章,评审
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更新日期：2008-02-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
doi：10.1016/j.autrev.2010.10.003
更新日期：2011-02-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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